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    Klhl12 kelch-like family member 12 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 266772, updated on 27-Nov-2024

    Summary

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    Official Symbol
    Klhl12provided by RGD
    Official Full Name
    kelch-like family member 12provided by RGD
    Primary source
    RGD:628717
    See related
    EnsemblRapid:ENSRNOG00000004193 AllianceGenome:RGD:628717
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Also known as
    C3ip1
    Summary
    Predicted to enable identical protein binding activity and ubiquitin-like ligase-substrate adaptor activity. Predicted to be involved in several processes, including COPII vesicle coating; mesenchymal cell differentiation; and protein monoubiquitination. Predicted to be located in centriolar satellite and intracellular membrane-bounded organelle. Predicted to be part of COPII vesicle coat and Cul3-RING ubiquitin ligase complex. Predicted to be active in COPII-coated ER to Golgi transport vesicle. Orthologous to human KLHL12 (kelch like family member 12). [provided by Alliance of Genome Resources, Nov 2024]
    Expression
    Biased expression in Testes (RPKM 102.3), Adrenal (RPKM 93.5) and 9 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Klhl12 in Genome Data Viewer
    Location:
    13q13
    Exon count:
    16
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 13 NC_086031.1 (48451920..48485638)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 13 NC_051348.1 (45899913..45933648)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 13 NC_005112.4 (51280933..51314753)

    Chromosome 13 - NC_086031.1Genomic Context describing neighboring genes Neighboring gene adiponectin receptor 1 Neighboring gene long non-coding RNA 134 Neighboring gene NADH:ubiquinone oxidoreductase subunit V3, pseudogene 1 Neighboring gene uncharacterized LOC134481560 Neighboring gene RAB interacting factor

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins--brief report. Butkinaree C, et al. Arterioscler Thromb Vasc Biol, 2014 Feb. PMID 24334870, Free PMC Article
    2. Ubiquitin-dependent regulation of COPII coat size and function. Jin L, et al. Nature, 2012 Feb 22. PMID 22358839, Free PMC Article
    3. Nucleoredoxin sustains Wnt/β-catenin signaling by retaining a pool of inactive dishevelled protein. Funato Y, et al. Curr Biol, 2010 Nov 9. PMID 20970343
    4. Regulation of the CUL3 Ubiquitin Ligase by a Calcium-Dependent Co-adaptor. McGourty CA, et al. Cell, 2016 Oct 6. PMID 27716508
    5. Pooled-matrix protein interaction screens using Barcode Fusion Genetics. Yachie N, et al. Mol Syst Biol, 2016 Apr 22. PMID 27107012, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. KLHL12 plays a critical role in facilitating the endoplasmic reticulum exit and secretion of apoB100-VLDL particles, suggesting that KLHL12 modulation would influence plasma lipid levels.
      Title: A regulator of secretory vesicle size, Kelch-like protein 12, facilitates the secretion of apolipoprotein B100 and very-low-density lipoproteins--brief report.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Clone Names

    • MGC93127

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables identical protein binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables identical protein binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ubiquitin-like ligase-substrate adaptor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in COPII vesicle coating IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in COPII vesicle coating IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in COPII vesicle coating ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in COPII vesicle coating ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in Wnt signaling pathway ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in Wnt signaling pathway ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in endoplasmic reticulum to Golgi vesicle-mediated transport ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neural crest cell development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest cell development ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest cell development ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in neural crest formation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in neural crest formation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neural crest formation ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    involved_in proteasome-mediated ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in protein monoubiquitination IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in protein monoubiquitination ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in protein monoubiquitination ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    Component Evidence Code Pubs
    part_of COPII vesicle coat IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of COPII vesicle coat ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of COPII vesicle coat ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    is_active_in COPII-coated ER to Golgi transport vesicle IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in COPII-coated ER to Golgi transport vesicle ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex IEA
    Inferred from Electronic Annotation
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of Cul3-RING ubiquitin ligase complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  
    located_in centriolar satellite IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in centriolar satellite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    kelch-like protein 12
    Names
    CUL3-interacting protein 1
    kelch-like 12
    kelch-like protein C3IP1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001433872.1 → NP_001420801.1  kelch-like protein 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    2. NM_001433873.1 → NP_001420802.1  kelch-like protein 12

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013

    3. NM_153730.3 → NP_714952.1  kelch-like protein 12

      See identical proteins and their annotated locations for NP_714952.1

      Status: VALIDATED

      Source sequence(s)
      JAXUCZ010000013
      UniProtKB/TrEMBL
      A6ICC3
      Related
      ENSRNOP00000005832.8, ENSRNOT00000005832.8
      Conserved Domains (4) summary
      PHA03098
      Location:46 → 550
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:416 → 459
      Kelch; KELCH repeat [structural motif]
      cd18242
      Location:12 → 135
      BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
      cd18452
      Location:130 → 265
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086031.1 Reference GRCr8

      Range
      48451920..48485638
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039090401.2 → XP_038946329.1  kelch-like protein 12 isoform X1

      Conserved Domains (4) summary
      PHA03098
      Location:63 → 574
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:440 → 483
      Kelch; KELCH repeat [structural motif]
      cd18242
      Location:29 → 159
      BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
      cd18452
      Location:154 → 289
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    2. XM_039090402.2 → XP_038946330.1  kelch-like protein 12 isoform X2

      UniProtKB/TrEMBL
      A0A8I6A1G7
      Conserved Domains (4) summary
      PHA03098
      Location:63 → 567
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:433 → 476
      Kelch; KELCH repeat [structural motif]
      cd18242
      Location:29 → 152
      BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
      cd18452
      Location:147 → 282
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    3. XM_006249843.5 → XP_006249905.1  kelch-like protein 12 isoform X3

      See identical proteins and their annotated locations for XP_006249905.1

      UniProtKB/TrEMBL
      A0A140TA97
      Related
      ENSRNOP00000086049.2, ENSRNOT00000119533.2
      Conserved Domains (4) summary
      PHA03098
      Location:46 → 557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 466
      Kelch; KELCH repeat [structural motif]
      cd18242
      Location:12 → 142
      BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
      cd18452
      Location:137 → 272
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    4. XM_039090408.2 → XP_038946336.1  kelch-like protein 12 isoform X6

      Conserved Domains (4) summary
      PHA03098
      Location:83 → 443
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:309 → 352
      Kelch; KELCH repeat [structural motif]
      cl38908
      Location:29 → 82
      BTB_POZ; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain superfamily
      cl28903
      Location:82 → 158
      BACK; BACK (BTB and C-terminal Kelch) domain

    5. XM_039090404.2 → XP_038946332.1  kelch-like protein 12 isoform X3

      UniProtKB/TrEMBL
      A0A140TA97
      Conserved Domains (4) summary
      PHA03098
      Location:46 → 557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 466
      Kelch; KELCH repeat [structural motif]
      cd18242
      Location:12 → 142
      BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
      cd18452
      Location:137 → 272
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    6. XM_063272056.1 → XP_063128126.1  kelch-like protein 12 isoform X4

      UniProtKB/TrEMBL
      A6ICC3

    7. XM_006249845.3 → XP_006249907.1  kelch-like protein 12 isoform X4

      UniProtKB/TrEMBL
      A6ICC3
      Conserved Domains (4) summary
      PHA03098
      Location:46 → 550
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:416 → 459
      Kelch; KELCH repeat [structural motif]
      cd18242
      Location:12 → 135
      BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
      cd18452
      Location:130 → 265
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    8. XM_006249844.5 → XP_006249906.1  kelch-like protein 12 isoform X3

      See identical proteins and their annotated locations for XP_006249906.1

      UniProtKB/TrEMBL
      A0A140TA97
      Conserved Domains (4) summary
      PHA03098
      Location:46 → 557
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:423 → 466
      Kelch; KELCH repeat [structural motif]
      cd18242
      Location:12 → 142
      BTB_POZ_KLHL12_C3IP1_DKIR; BTB (Broad-Complex, Tramtrack and Bric a brac)/POZ (poxvirus and zinc finger) domain found in Kelch-like protein 12 (KLHL12)
      cd18452
      Location:137 → 272
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    9. XM_008769540.4 → XP_008767762.1  kelch-like protein 12 isoform X5

      See identical proteins and their annotated locations for XP_008767762.1

      Conserved Domains (3) summary
      PHA03098
      Location:4 → 467
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18452
      Location:47 → 182
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    10. XM_039090405.2 → XP_038946333.1  kelch-like protein 12 isoform X5

      Conserved Domains (3) summary
      PHA03098
      Location:4 → 467
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18452
      Location:47 → 182
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    11. XM_039090406.2 → XP_038946334.1  kelch-like protein 12 isoform X5

      Conserved Domains (3) summary
      PHA03098
      Location:4 → 467
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18452
      Location:47 → 182
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)

    12. XM_039090407.2 → XP_038946335.1  kelch-like protein 12 isoform X5

      Conserved Domains (3) summary
      PHA03098
      Location:4 → 467
      PHA03098; kelch-like protein; Provisional
      sd00038
      Location:333 → 376
      Kelch; KELCH repeat [structural motif]
      cd18452
      Location:47 → 182
      BACK_KLHL12; BACK (BTB and C-terminal Kelch) domain found in Kelch-like protein 12 (KLHL12)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R2H4.2 GenPept UniProtKB/Swiss-Prot:Q8R2H4

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