Cd274 CD274 molecule [Rattus norvegicus (Norway rat)] - Gene

Summary

Official Symbol: Cd274provided by RGD
Official Full Name: CD274 moleculeprovided by RGD
Primary source: RGD:1566211
See related: EnsemblRapid:ENSRNOG00000016112 AllianceGenome:RGD:1566211
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Rattus norvegicus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
Also known as: Pdcd1lg1; RGD1566211
Summary: Predicted to enable receptor ligand activity and transcription coactivator activity. Involved in positive regulation of T cell proliferation and positive regulation of cell migration. Located in cell surface. Biomarker of periodontitis and pre-eclampsia. Orthologous to human CD274 (CD274 molecule). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in Thymus (RPKM 102.9), Spleen (RPKM 58.3) and 9 other tissues See more
Orthologs: human mouse all
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Genomic context

Location:: 1q52

Exon count:: 9

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCr8 (GCF_036323735.1)	1	NC_086019.1 (236526215..236549956)
RS_2023_06	previous assembly	mRatBN7.2 (GCF_015227675.2)	1	NC_051336.1 (227116674..227137379)
106	previous assembly	Rnor_6.0 (GCF_000001895.5)	1	NC_005100.4 (247519890..247539659)

Chromosome 1 - NC_086019.1 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
BioProject: PRJNA238328
Publication: PMID 24510058
Analysis date: Mon Jun 6 17:44:12 2016

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PD-L1 and AKT Overexpressing Adipose-Derived Mesenchymal Stem Cells Enhance Myocardial Protection by Upregulating CD25[+] T Cells in Acute Myocardial Infarction Rat Model.
Title: PD-L1 and AKT Overexpressing Adipose-Derived Mesenchymal Stem Cells Enhance Myocardial Protection by Upregulating CD25(+) T Cells in Acute Myocardial Infarction Rat Model.
Pulmonary endothelium-derived PD-L1 induced by the H9N2 avian influenza virus inhibits the immune response of T cells.
Title: Pulmonary endothelium-derived PD-L1 induced by the H9N2 avian influenza virus inhibits the immune response of T cells.
Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension.
Title: Programmed death-ligand 1 triggers PASMCs pyroptosis and pulmonary vascular fibrosis in pulmonary hypertension.
this study shows that bone marrow mesenchymal stromal cells attenuate liver allograft rejection may via upregulation PD-L1 expression through downregulation of miR-17-5p
Title: Bone marrow mesenchymal stromal cells attenuate liver allograft rejection may via upregulation PD-L1 expression through downregulation of miR-17-5p.
In conclusion, the findings presented in this article demonstrate that PD-L1 expression in kupffer cells can depress activation, promote apoptosis and decrease cytokine production of T lymphocytes, which could prevent acute rejection and prolong survival time in recipient.
Title: Role of programmed death ligand 1 and Kupffer cell in immune regulation after orthotopic liver transplantation in rats.
Programmed death-ligand 1 expression increases after intracerebral hemorrhage.
Title: Roles of programmed death protein 1/programmed death-ligand 1 in secondary brain injury after intracerebral hemorrhage in rats: selective modulation of microglia polarization to anti-inflammatory phenotype.
Upregulation of PD-1 and PD-L1 was associated with marked increases in GADD153 during myocardial ischemic reperfusion injury.
Title: Upregulation of Programmed Death-1 and Its Ligand in Cardiac Injury Models: Interaction with GADD153.
Findings suggested that DC/Ad-PD-L1 could induce CD8+ T cell tolerance and lead to kidney allograft tolerance, which provided a promising finding for clinical application.
Title: Dendritic cells transfected with PD-L1 recombinant adenovirus induces T cell suppression and long-term acceptance of allograft transplantation.

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General gene information

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Gene Ontology Provided by RGD

Function	Evidence Code	Pubs
enables receptor ligand activity	ISO Inferred from Sequence Orthology more info
enables transcription coactivator activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in T cell costimulation	IBA Inferred from Biological aspect of Ancestor more info
involved_in T cell costimulation	ISO Inferred from Sequence Orthology more info
involved_in TRIF-dependent toll-like receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cell surface receptor signaling pathway	IBA Inferred from Biological aspect of Ancestor more info
involved_in cell surface receptor signaling pathway	ISO Inferred from Sequence Orthology more info
involved_in cellular response to lipopolysaccharide	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	IBA Inferred from Biological aspect of Ancestor more info
involved_in immune response	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD4-positive, alpha-beta T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of CD8-positive, alpha-beta T cell activation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell mediated immune response to tumor cell	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
acts_upstream_of_or_within negative regulation of T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of tumor necrosis factor superfamily cytokine production	ISO Inferred from Sequence Orthology more info
involved_in negative regulation of type II interferon production	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of DNA-templated transcription	IEA Inferred from Electronic Annotation more info
involved_in positive regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of T cell proliferation	IBA Inferred from Biological aspect of Ancestor more info
involved_in positive regulation of T cell proliferation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of activated CD8-positive, alpha-beta T cell apoptotic process	ISO Inferred from Sequence Orthology more info
involved_in positive regulation of cell migration	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in positive regulation of interleukin-10 production	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of T cell apoptotic process	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of activated CD4-positive, alpha-beta T cell apoptotic process	ISO Inferred from Sequence Orthology more info
NOT involved_in regulation of activated T cell proliferation	ISO Inferred from Sequence Orthology more info
involved_in response to cytokine	ISO Inferred from Sequence Orthology more info
involved_in signal transduction	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in actin cytoskeleton	IEA Inferred from Electronic Annotation more info
located_in actin cytoskeleton	ISO Inferred from Sequence Orthology more info
located_in cell surface	IDA Inferred from Direct Assay more info	PubMed
located_in early endosome membrane	ISO Inferred from Sequence Orthology more info
is_active_in external side of plasma membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in external side of plasma membrane	ISO Inferred from Sequence Orthology more info
located_in extracellular exosome	ISO Inferred from Sequence Orthology more info
located_in nucleoplasm	ISO Inferred from Sequence Orthology more info
NOT is_active_in nucleus	ISO Inferred from Sequence Orthology more info
located_in plasma membrane	ISO Inferred from Sequence Orthology more info
located_in recycling endosome membrane	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: programmed cell death 1 ligand 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001191954.2 → NP_001178883.1 programmed cell death 1 ligand 1 precursor

See identical proteins and their annotated locations for NP_001178883.1

Status: VALIDATED

Source sequence(s)

JAXUCZ010000001

UniProtKB/TrEMBL

A6I0W4, D4AE25

Related

ENSRNOP00000105704.1, ENSRNOT00000157954.1

Conserved Domains (2) summary

cd00096
Location:21 → 24

Ig; Ig strand A [structural motif]

cl11960
Location:21 → 130

Ig; Immunoglobulin domain

RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCr8

Genomic

NC_086019.1 Reference GRCr8

Range

236526215..236549956

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_063271728.1 → XP_063127798.1 programmed cell death 1 ligand 1 isoform X1

UniProtKB/TrEMBL

A6I0W4, D4AE25
XM_039088034.2 → XP_038943962.1 programmed cell death 1 ligand 1 isoform X1

UniProtKB/TrEMBL

A6I0W4, D4AE25

Related

ENSRNOP00000029992.5, ENSRNOT00000034421.8

Conserved Domains (2) summary

cd00096
Location:21 → 24

Ig; Ig strand A [structural motif]

cl11960
Location:21 → 130

Ig; Immunoglobulin domain
XM_039088029.2 → XP_038943957.1 programmed cell death 1 ligand 1 isoform X1

UniProtKB/TrEMBL

A6I0W4, D4AE25

Conserved Domains (2) summary

cd00096
Location:21 → 24

Ig; Ig strand A [structural motif]

cl11960
Location:21 → 130

Ig; Immunoglobulin domain