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    Ndrg2 NDRG family member 2 [ Rattus norvegicus (Norway rat) ]

    Gene ID: 171114, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ndrg2provided by RGD
    Official Full Name
    NDRG family member 2provided by RGD
    Primary source
    RGD:621874
    See related
    EnsemblRapid:ENSRNOG00000010389 AllianceGenome:RGD:621874
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to be involved in signal transduction and substantia nigra development. Predicted to act upstream of or within negative regulation of ERK1 and ERK2 cascade; negative regulation of vascular associated smooth muscle cell proliferation; and regulation of cytokine production. Predicted to be located in Golgi apparatus and nucleus. Predicted to be active in cytoplasm. Orthologous to human NDRG2 (NDRG family member 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Muscle (RPKM 3258.5), Heart (RPKM 3084.1) and 7 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Ndrg2 in Genome Data Viewer
    Location:
    15p14
    Exon count:
    20
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 15 NC_086033.1 (27074481..27087376, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 15 NC_051350.1 (24600981..24609621, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 15 NC_005114.4 (28305820..28314459, complement)

    Chromosome 15 - NC_086033.1Genomic Context describing neighboring genes Neighboring gene methyltransferase like 17 Neighboring gene solute carrier family 39 member 2 Neighboring gene tubulin polymerization-promoting protein family member 2 Neighboring gene ribonuclease A family member 13

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats. Zhao J, et al. Hum Exp Toxicol, 2021 Aug. PMID 33583230
    2. Characterization of rat NDRG2 (N-Myc downstream regulated gene 2), a novel early mineralocorticoid-specific induced gene. Boulkroun S, et al. J Biol Chem, 2002 Aug 30. PMID 12072429
    3. Ndrg2, a novel gene regulated by adrenal steroids and antidepressants, is highly expressed in astrocytes. Nichols NR. Ann N Y Acad Sci, 2003 Dec. PMID 14993068
    4. Expression of Ndrg2 in the rat frontal cortex after antidepressant and electroconvulsive treatment. Takahashi K, et al. Int J Neuropsychopharmacol, 2005 Sep. PMID 15769300
    5. Ndrg2 promotes neurite outgrowth of NGF-differentiated PC12 cells. Takahashi K, et al. Neurosci Lett, 2005 Nov 18. PMID 16039777

    See all (34) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.
      Title: Transformation of A1/A2 Astrocytes Participates in Brain Ischemic Tolerance Induced by Cerebral Ischemic Preconditioning via Inhibiting NDRG2.
    2. N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats.
      Title: N-myc downstream regulated gene 2 ameliorates myocardial remodeling and cardiac function in heart failure rats.
    3. MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.
      Title: MiR-130a/Ndrg2 Axis Inhibits the Proliferation of Fibroblast-Like Synoviocytes in Rheumatoid Arthritis.
    4. Astrocytic NDRG2 is critical in the maintenance of neuropathic pain.
      Title: Astrocytic NDRG2 is critical in the maintenance of neuropathic pain.
    5. Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
      Title: Association between NDRG2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
    6. Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
      Title: Relationship between miR-375 regulating Ndrg2/IL-6/STAT3 signaling pathway and diabetic retinopathy in rats.
    7. Increased level of NDRG2 in cortex or hippocampus may be a potential risk for Alzheimer's disease. NDRG2 increased Abeta1-42 might be related to the changes of BEAC1 and GGA3. It might also affect CDK5 and tau overphosphorylation. NDRG2 interacting with STAT3 and modulating Fas/Fasl signaling pathway plays important roles in cell death.
      Title: The pathological roles of NDRG2 in Alzheimer's disease, a study using animal models and APPwt-overexpressed cells.
    8. 2-arachidonylglycerol protects primary astrocytes exposed to oxygen-glucose deprivation through a blockade of NDRG2 signaling and STAT3 phosphorylation.
      Title: 2-Arachidonylglycerol Protects Primary Astrocytes Exposed to Oxygen-Glucose Deprivation Through a Blockade of NDRG2 Signaling and STAT3 Phosphorylation.
    9. Our results demonstrated that NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
      Title: NDRG2 promoted secreted miR-375 in microvesicles shed from M1 microglia, which induced neuron damage.
    10. We further showed that the localized delivery of NDRG2 improved the dysfunction of Na(+) and Cl(-) reabsorption
      Title: Retrograde ductal administration of the adenovirus-mediated NDRG2 gene leads to improved sialaden hypofunction in estrogen-deficient rats.
    Submit: New GeneRIF Correction See all GeneRIFs (20)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Process Evidence Code Pubs
    involved_in Wnt signaling pathway IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in cell differentiation IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in negative regulation of ERK1 and ERK2 cascade IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of ERK1 and ERK2 cascade ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of cytokine production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of cytokine production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in negative regulation of vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within negative regulation of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nervous system development IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in regulation of platelet-derived growth factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of platelet-derived growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in regulation of vascular endothelial growth factor production IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of vascular endothelial growth factor production ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in signal transduction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in substantia nigra development ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    involved_in vascular associated smooth muscle cell proliferation IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of vascular associated smooth muscle cell proliferation ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    located_in Golgi apparatus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in growth cone IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in nucleus ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perinuclear region of cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    protein NDRG2
    Names
    N-myc downstream regulated gene 2
    N-myc downstream-regulated gene 2 protein
    NDRG1-related protein
    antidepressant-related protein ADRG123

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001270862.1 → NP_001257791.1  protein NDRG2 isoform a

      See identical proteins and their annotated locations for NP_001257791.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longer isoform (a). Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AF334105, FM045410
      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A0A0G2JSV0, A6KEE6
      Related
      ENSRNOP00000042949.1, ENSRNOT00000042055.5
      Conserved Domains (2) summary
      COG0596
      Location:119 → 313
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    2. NM_001270863.1 → NP_001257792.1  protein NDRG2 isoform a

      See identical proteins and their annotated locations for NP_001257792.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1 and 3 both encode the same isoform (a).
      Source sequence(s)
      AF334105, FM057759
      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A0A0G2JSV0, A6KEE6
      Conserved Domains (2) summary
      COG0596
      Location:119 → 313
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:40 → 318
      Ndr; Ndr family

    3. NM_001270864.1 → NP_001257793.1  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_001257793.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (4) differs in the 5' UTR and lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AF334106, FM057759
      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A6KEE4
      Related
      ENSRNOP00000081522.2, ENSRNOT00000094910.2
      Conserved Domains (2) summary
      COG0596
      Location:105 → 299
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    4. NM_133583.2 → NP_598267.2  protein NDRG2 isoform b

      See identical proteins and their annotated locations for NP_598267.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon compared to variant 1. The resulting isoform (b) has the same N- and C-termini but is shorter compared to isoform a. Variants 2 and 4 both encode the same isoform (b).
      Source sequence(s)
      AF334106, FM045410
      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A6KEE4
      Conserved Domains (2) summary
      COG0596
      Location:105 → 299
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
      pfam03096
      Location:26 → 304
      Ndr; Ndr family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086033.1 Reference GRCr8

      Range
      27074481..27087376 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_063273931.1 → XP_063130001.1  protein NDRG2 isoform X6

      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A6KEE4

    2. XM_063273927.1 → XP_063129997.1  protein NDRG2 isoform X2

      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01

    3. XM_039092969.2 → XP_038948897.1  protein NDRG2 isoform X5

      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A0A0G2JSU4

    4. XM_063273930.1 → XP_063130000.1  protein NDRG2 isoform X6

      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A6KEE4

    5. XM_063273929.1 → XP_063129999.1  protein NDRG2 isoform X4

      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A0A0G2JSV0, A6KEE6

    6. XM_063273928.1 → XP_063129998.1  protein NDRG2 isoform X3

      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A0A8I5ZS65

    7. XM_063273926.1 → XP_063129996.1  protein NDRG2 isoform X1

      UniProtKB/Swiss-Prot
      Q8VBU2, Q8VBW2, Q8VI00, Q8VI01
      UniProtKB/TrEMBL
      A0A0G2K3T7
      Related
      ENSRNOP00000039619.3, ENSRNOT00000040540.4
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8VBU2.1 GenPept UniProtKB/Swiss-Prot:Q8VBU2

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
    Molecular Biology Databases
    Research Materials
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