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    Nnmt nicotinamide N-methyltransferase [ Rattus norvegicus (Norway rat) ]

    Gene ID: 300691, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Nnmtprovided by RGD
    Official Full Name
    nicotinamide N-methyltransferaseprovided by RGD
    Primary source
    RGD:1309606
    See related
    EnsemblRapid:ENSRNOG00000005930 AllianceGenome:RGD:1309606
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Rattus norvegicus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Rattus
    Summary
    Predicted to enable nicotinamide N-methyltransferase activity. Involved in animal organ regeneration and response to xenobiotic stimulus. Predicted to be active in cytosol. Human ortholog(s) of this gene implicated in abdominal aortic aneurysm. Orthologous to human NNMT (nicotinamide N-methyltransferase). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in Liver (RPKM 45.2), Adrenal (RPKM 26.5) and 8 other tissues See more
    Orthologs
    human mouse all
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    Genomic context

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    See Nnmt in Genome Data Viewer
    Location:
    8q23
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCr8 (GCF_036323735.1) 8 NC_086026.1 (57820156..57851301, complement)
    RS_2023_06 previous assembly mRatBN7.2 (GCF_015227675.2) 8 NC_051343.1 (48928663..48947734, complement)
    106 previous assembly Rnor_6.0 (GCF_000001895.5) 8 NC_005107.4 (52918437..52938172, complement)

    Chromosome 8 - NC_086026.1Genomic Context describing neighboring genes Neighboring gene similar to human chromosome 11 open reading frame 71 Neighboring gene RNA binding motif protein 7 Neighboring gene uncharacterized LOC120094143 Neighboring gene zinc finger and BTB domain containing 16 Neighboring gene uncharacterized LOC120094144 Neighboring gene uncharacterized LOC134480046

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: A rat RNA-Seq transcriptomic BodyMap across 11 organs and 4 developmental stages
    • Description: 320 RNA samples isolated from 11 organs (adrenal gland, brain, heart, kidney, liver, lung, muscle, spleen, thymus, and testes or uterus) from both sexes of Fischer 344 rats across four developmental stages (2-, 6-, 21-, and 104-weeks-old)
    • BioProject: PRJNA238328
    • Publication: PMID 24510058
    • Analysis date: Mon Jun 6 17:44:12 2016

    Bibliography

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    Related articles in PubMed

    1. Serum N1-Methylnicotinamide is Associated With Coronary Artery Disease in Chinese Patients. Liu M, et al. J Am Heart Assoc, 2017 Feb 7. PMID 28174167, Free PMC Article
    2. Methylation of nicotinamide in rat liver cytosol and its correlation with hepatocellular proliferation. Hoshino J, et al. Biochim Biophys Acta, 1982 Dec 17. PMID 6217846
    3. Nicotinamide methylation. Tissue distribution, developmental and neoplastic changes. Seifert R, et al. Biochim Biophys Acta, 1984 Sep 28. PMID 6236853
    4. Increase of nicotinamide methyltransferase and N1-methyl-nicotinamide oxidase activities in the livers of the rats administered alkylating agents. Ohkubo M, et al. Cancer Lett, 1983 Dec. PMID 6652621
    5. Gene expression analysis of renal carcinoma: adipose differentiation-related protein as a potential diagnostic and prognostic biomarker for clear-cell renal carcinoma. Yao M, et al. J Pathol, 2005 Feb. PMID 15682440

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Progression of pulmonary hypertension is associated with the activation of the NNMT-1-methylnicotinamide pathway.
      Title: Activation of the nicotinamide N-methyltransferase (NNMT)-1-methylnicotinamide (MNA) pathway in pulmonary hypertension.
    2. The downregulation of NNMT by PEITC is a novel finding that may represent an important mechanism for the cancer preventive effects of dietary PEITC.
      Title: Effect of orally administered phenethyl isothiocyanate on hepatic gene expression in rats.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    General gene information

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    Markers

    Homology

    Gene Ontology Provided by RGD

    Function Evidence Code Pubs
    enables nicotinamide N-methyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables nicotinamide N-methyltransferase activity ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables selenol Se-methyltransferase activity TAS
    Traceable Author Statement
    more info
    		  
    Process Evidence Code Pubs
    involved_in animal organ regeneration IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within methylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in nicotinamide metabolic process ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of gluconeogenesis ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in positive regulation of protein deacetylation ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in response to xenobiotic stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    is_active_in cytosol IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in cytosol TAS
    Traceable Author Statement
    more info
    		  

    General protein information

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    Preferred Names
    nicotinamide N-methyltransferase
    NP_001100289.1
    XP_038936990.1
    XP_038936991.1
    XP_038936993.1
    XP_038936994.1
    XP_038936995.1
    XP_063121183.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001106819.1 → NP_001100289.1  nicotinamide N-methyltransferase

      See identical proteins and their annotated locations for NP_001100289.1

      Status: PROVISIONAL

      Source sequence(s)
      CH473975
      UniProtKB/TrEMBL
      A6J4A4, D4A605
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 259
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    RefSeqs of Annotated Genomes: GCF_036323735.1-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCr8

    Genomic

    1. NC_086026.1 Reference GRCr8

      Range
      57820156..57851301 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_039081062.2 → XP_038936990.1  nicotinamide N-methyltransferase isoform X2

      Related
      ENSRNOP00000086644.2, ENSRNOT00000117251.2
      Conserved Domains (1) summary
      pfam01234
      Location:2 → 236
      NNMT_PNMT_TEMT; NNMT/PNMT/TEMT family

    2. XM_063265113.1 → XP_063121183.1  nicotinamide N-methyltransferase isoform X1

      UniProtKB/TrEMBL
      A6J4A4, D4A605

    3. XM_039081065.2 → XP_038936993.1  nicotinamide N-methyltransferase isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:18 → 164
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    4. XM_039081066.2 → XP_038936994.1  nicotinamide N-methyltransferase isoform X4

      Conserved Domains (1) summary
      cl17173
      Location:18 → 164
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    5. XM_039081067.2 → XP_038936995.1  nicotinamide N-methyltransferase isoform X5

      Conserved Domains (1) summary
      cl17173
      Location:2 → 121
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...

    6. XM_039081063.2 → XP_038936991.1  nicotinamide N-methyltransferase isoform X3

      Conserved Domains (1) summary
      cl17173
      Location:2 → 136
      AdoMet_MTases; S-adenosylmethionine-dependent methyltransferases (SAM or AdoMet-MTase), class I; AdoMet-MTases are enzymes that use S-adenosyl-L-methionine (SAM or AdoMet) as a substrate for methyltransfer, creating the product S-adenosyl-L-homocysteine (AdoHcy). ...
    Nucleotide Protein Strain
    Heading Accession and Version

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