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    TSPAN2 tetraspanin 2 [ Homo sapiens (human) ]

    Gene ID: 10100, updated on 3-Dec-2024

    Summary

    Official Symbol
    TSPAN2provided by HGNC
    Official Full Name
    tetraspanin 2provided by HGNC
    Primary source
    HGNC:HGNC:20659
    See related
    Ensembl:ENSG00000134198 MIM:613133; AllianceGenome:HGNC:20659
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Homo sapiens
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo
    Also known as
    NET3; TSN2; TSPAN-2
    Summary
    The protein encoded by this gene is a member of the transmembrane 4 superfamily, also known as the tetraspanin family. Most of these members are cell-surface proteins that are characterized by the presence of four hydrophobic domains. The proteins mediate signal transduction events that play a role in the regulation of cell development, activation, growth and motility. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Apr 2015]
    Expression
    Broad expression in endometrium (RPKM 16.8), urinary bladder (RPKM 10.7) and 19 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See TSPAN2 in Genome Data Viewer
    Location:
    1p13.2
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_08 current GRCh38.p14 (GCF_000001405.40) 1 NC_000001.11 (115048011..115089503, complement)
    RS_2024_08 current T2T-CHM13v2.0 (GCF_009914755.1) 1 NC_060925.1 (115059448..115100954, complement)
    RS_2024_09 previous assembly GRCh37.p13 (GCF_000001405.25) 1 NC_000001.10 (115590632..115632124, complement)

    Chromosome 1 - NC_000001.11Genomic Context describing neighboring genes Neighboring gene uncharacterized LOC105378915 Neighboring gene synaptonemal complex protein 1 Neighboring gene Sharpr-MPRA regulatory region 5363 Neighboring gene NANOG hESC enhancer GRCh37_chr1:115589292-115589828 Neighboring gene H3K4me1 hESC enhancer GRCh37_chr1:115604953-115605476 Neighboring gene uncharacterized LOC124904359 Neighboring gene thyroid stimulating hormone subunit beta Neighboring gene ATAC-STARR-seq lymphoblastoid active region 1554 Neighboring gene long intergenic non-protein coding RNA 1765 Neighboring gene NANOG-H3K27ac-H3K4me1 hESC enhancer GRCh37_chr1:115690783-115691409 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:115721881-115723080 Neighboring gene CDK7 strongly-dependent group 2 enhancer GRCh37_chr1:115800386-115801585 Neighboring gene BRD4-independent group 4 enhancer GRCh37_chr1:115842590-115843789 Neighboring gene NGF antisense RNA 1 Neighboring gene nerve growth factor

    Genomic regions, transcripts, and products

    Expression

    • Project title: HPA RNA-seq normal tissues
    • Description: RNA-seq was performed of tissue samples from 95 human individuals representing 27 different tissues in order to determine tissue-specificity of all protein-coding genes
    • BioProject: PRJEB4337
    • Publication: PMID 24309898
    • Analysis date: Wed Apr 4 07:08:55 2018

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Clone Names

    • FLJ12082

    Gene Ontology Provided by GOA

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in astrocyte development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in axon development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in inflammatory response IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microglia development IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in myelination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in oligodendrocyte differentiation IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in membrane TAS
    Traceable Author Statement
    more info
    PubMed 
    located_in myelin sheath IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm IDA
    Inferred from Direct Assay
    more info
     
    is_active_in plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     

    General protein information

    Preferred Names
    tetraspanin-2
    Names
    new EST tetraspan 3
    tetraspan 2
    tetraspan NET-3
    tetraspan TM4SF

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001308315.2NP_001295244.1  tetraspanin-2 isoform 2

      See identical proteins and their annotated locations for NP_001295244.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (2) lacks an alternate in-frame exon in the central coding region compared to variant 1. It encodes isoform 2, which has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AA724831, AK022144, AL109660, AU117697, AW015874, AW051326, BG697236, CB993308
      Consensus CDS
      CCDS76193.1
      UniProtKB/TrEMBL
      B1AKP1, B2RD31
      Related
      ENSP00000358528.2, ENST00000369515.6
      Conserved Domains (2) summary
      cd03151
      Location:85161
      CD81_like_LEL; Tetraspanin, extracellular domain or large extracellular loop (LEL), CD81_like subfamily. Tetraspanins are trans-membrane proteins with 4 trans-membrane segments. Both the N- and C-termini lie on the intracellular side of the membrane. This alignment ...
      pfam00335
      Location:11185
      Tetraspannin; Tetraspanin family
    2. NM_001308316.2NP_001295245.1  tetraspanin-2 isoform 3

      See identical proteins and their annotated locations for NP_001295245.1

      Status: REVIEWED

      Description
      Transcript Variant: This variant (3) lacks an alternate in-frame exon in the 3' coding region compared to variant 1. It encodes isoform 3, which has the same N- and C-termini, but is shorter than isoform 1.
      Source sequence(s)
      AA724831, AK022144, AL109660, AU117697, AW015874, AW051326, BG697236, CB993308, GU971730
      UniProtKB/TrEMBL
      B1AKP2
      Related
      ENSP00000415256.1, ENST00000433172.3
      Conserved Domains (1) summary
      pfam00335
      Location:11158
      Tetraspannin; Tetraspanin family
    3. NM_005725.6NP_005716.2  tetraspanin-2 isoform 1

      See identical proteins and their annotated locations for NP_005716.2

      Status: REVIEWED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AA724831, AK022144, AK315385, AL109660, AU117697, AW015874, AW051326, BG697236, CB993308
      Consensus CDS
      CCDS881.1
      UniProtKB/Swiss-Prot
      D6PTH4, O60636, Q5TET2, Q8WU05
      UniProtKB/TrEMBL
      B2RD31
      Related
      ENSP00000358529.2, ENST00000369516.7
      Conserved Domains (1) summary
      pfam00335
      Location:11210
      Tetraspannin; Tetraspanin family

    RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2024_08

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCh38.p14 Primary Assembly

    Genomic

    1. NC_000001.11 Reference GRCh38.p14 Primary Assembly

      Range
      115048011..115089503 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_016999996.2XP_016855485.1  tetraspanin-2 isoform X1

      UniProtKB/TrEMBL
      B1AKP2

    Alternate T2T-CHM13v2.0

    Genomic

    1. NC_060925.1 Alternate T2T-CHM13v2.0

      Range
      115059448..115100954 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_054333723.1XP_054189698.1  tetraspanin-2 isoform X1

      UniProtKB/TrEMBL
      B1AKP2