Pfn4 profilin family, member 4 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pfn4provided by MGI
Official Full Name: profilin family, member 4provided by MGI
Primary source: MGI:MGI:1920121
See related: Ensembl:ENSMUSG00000020639 AllianceGenome:MGI:1920121
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: 2900024P18Rik
Summary: Predicted to enable actin monomer binding activity. Involved in acrosome assembly; manchette assembly; and sperm flagellum assembly. Predicted to be located in cytoplasm. Predicted to be active in cell cortex. Is expressed in brain; ileum; and male reproductive gland or organ. Orthologous to human PFN4 (profilin family member 4). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in testis adult (RPKM 34.5), cortex adult (RPKM 2.0) and 2 other tissues See more
Orthologs: human all
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Genomic context

Location:: 12 A1.1; 12 2.09 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	12	NC_000078.7 (4819010..4828813)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	12	NC_000078.6 (4769015..4778813)

Chromosome 12 - NC_000078.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis.
Title: PFN4 is required for manchette development and acrosome biogenesis during mouse spermiogenesis.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2) 1 citation
Targeted (2)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables actin binding	IEA Inferred from Electronic Annotation more info
enables actin monomer binding	IBA Inferred from Biological aspect of Ancestor more info
enables lipid binding	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
involved_in acrosome assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in flagellated sperm motility	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in manchette assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in sequestering of actin monomers	IBA Inferred from Biological aspect of Ancestor more info
involved_in sperm flagellum assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in spermatogenesis	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
is_active_in cell cortex	IBA Inferred from Biological aspect of Ancestor more info
located_in cytoplasm	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: profilin-4

Names: profilin IV

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001361147.1 → NP_001348076.1 profilin-4

Status: VALIDATED

Description

Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Both variants 1 and 2 encode the same protein

Source sequence(s)

AY495949, BC094614, BI135172, CT025683

Consensus CDS

CCDS25790.1

UniProtKB/Swiss-Prot

Q6JEK6, Q9D6I3

UniProtKB/TrEMBL

A0A1W2P6U9

Related

ENSMUSP00000136765.2, ENSMUST00000178879.3

Conserved Domains (1) summary

pfam00235
Location:14 → 126

Profilin
NM_028376.4 → NP_082652.1 profilin-4

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript. Both variants 1 and 2 encode the same protein.

Source sequence(s)

BC094614, BI135172, CT025683

Consensus CDS

CCDS25790.1

UniProtKB/Swiss-Prot

Q6JEK6, Q9D6I3

UniProtKB/TrEMBL

A0A1W2P6U9

Related

ENSMUSP00000020967.5, ENSMUST00000020967.11

Conserved Domains (1) summary

pfam00235
Location:14 → 126

Profilin

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000078.7 Reference GRCm39 C57BL/6J

Range

4819010..4828813

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006515140.4 → XP_006515203.1 profilin-4 isoform X1

UniProtKB/Swiss-Prot

Q6JEK6, Q9D6I3

UniProtKB/TrEMBL

A0A1W2P6U9

Conserved Domains (1) summary

pfam00235
Location:14 → 126

Profilin
XM_006515138.3 → XP_006515201.1 profilin-4 isoform X1

UniProtKB/Swiss-Prot

Q6JEK6, Q9D6I3

UniProtKB/TrEMBL

A0A1W2P6U9

Conserved Domains (1) summary

pfam00235
Location:14 → 126

Profilin
XM_006515141.4 → XP_006515204.1 profilin-4 isoform X2

Conserved Domains (1) summary

pfam00235
Location:30 → 123

Profilin