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    Abhd8 abhydrolase domain containing 8 [ Mus musculus (house mouse) ]

    Gene ID: 64296, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Abhd8provided by MGI
    Official Full Name
    abhydrolase domain containing 8provided by MGI
    Primary source
    MGI:MGI:1918946
    See related
    Ensembl:ENSMUSG00000007950 AllianceGenome:MGI:1918946
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    0910001L24Rik
    Summary
    Predicted to enable carboxylic ester hydrolase activity and lysophosphatidic acid acyltransferase activity. Predicted to be involved in lipid homeostasis and phosphatidic acid biosynthetic process. Predicted to be active in mitochondrion. Is expressed in several structures, including adrenal gland; gallbladder; genitourinary system; gut; and nervous system. Orthologous to human ABHD8 (abhydrolase domain containing 8). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in cortex adult (RPKM 112.6), testis adult (RPKM 107.1) and 23 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Abhd8 in Genome Data Viewer
    Location:
    8 B3.3; 8 34.43 cM
    Exon count:
    6
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 8 NC_000074.7 (71909344..71917351, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 8 NC_000074.6 (71456700..71464707, complement)

    Chromosome 8 - NC_000074.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E1758 Neighboring gene STARR-positive B cell enhancer ABC_E9729 Neighboring gene predicted gene, 39193 Neighboring gene ankyrin repeat and LEM domain containing 1 Neighboring gene STARR-positive B cell enhancer ABC_E6651 Neighboring gene STARR-positive B cell enhancer ABC_E358 Neighboring gene mitochondrial ribosomal protein L34 Neighboring gene DET1 and DDB1 associated 1 Neighboring gene anoctamin 8

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Rapid and Integrative Discovery of Retina Regulatory Molecules. Albrecht NE, et al. Cell Rep, 2018 Aug 28. PMID 30157441, Free PMC Article
    2. Growth suppression of Escherichia coli by induction of expression of mammalian genes with transmembrane or ATPase domains. Inoue S, et al. Biochem Biophys Res Commun, 2000 Feb 16. PMID 10679242
    3. High-throughput discovery of novel developmental phenotypes. Dickinson ME, et al. Nature, 2016 Sep 22. PMID 27626380, Free PMC Article
    4. The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data. Koscielny G, et al. Nucleic Acids Res, 2014 Jan. PMID 24194600, Free PMC Article
    5. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199

    See all (19) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Targeted (2) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables carboxylic ester hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables lysophosphatidic acid acyltransferase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Process Evidence Code Pubs
    involved_in lipid homeostasis IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in phosphatidic acid biosynthetic process IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in mitochondrion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  

    General protein information

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    Preferred Names
    protein ABHD8
    Names
    abhydrolase domain-containing protein 8
    alpha/beta hydrolase domain-containing protein 8

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_022419.3 → NP_071864.2  protein ABHD8

      See identical proteins and their annotated locations for NP_071864.2

      Status: VALIDATED

      Source sequence(s)
      AC127416, AK003090
      Consensus CDS
      CCDS40382.1
      UniProtKB/Swiss-Prot
      Q8R0P8, Q9DC79, Q9JMF5
      Related
      ENSMUSP00000008094.9, ENSMUST00000008094.10
      Conserved Domains (1) summary
      COG0596
      Location:149 → 408
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000074.7 Reference GRCm39 C57BL/6J

      Range
      71909344..71917351 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_030243705.1 → XP_030099565.1  protein ABHD8 isoform X1

      UniProtKB/Swiss-Prot
      Q8R0P8, Q9DC79, Q9JMF5
      Conserved Domains (1) summary
      COG0596
      Location:149 → 408
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]

    2. XM_036154226.1 → XP_036010119.1  protein ABHD8 isoform X1

      UniProtKB/Swiss-Prot
      Q8R0P8, Q9DC79, Q9JMF5
      Conserved Domains (1) summary
      COG0596
      Location:149 → 408
      MhpC; Pimeloyl-ACP methyl ester carboxylesterase [Coenzyme transport and metabolism, General function prediction only]
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q8R0P8.1 GenPept UniProtKB/Swiss-Prot:Q8R0P8

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

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