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    Rbm17 RNA binding motif protein 17 [ Mus musculus (house mouse) ]

    Gene ID: 76938, updated on 9-Dec-2024

    Summary

    Official Symbol
    Rbm17provided by MGI
    Official Full Name
    RNA binding motif protein 17provided by MGI
    Primary source
    MGI:MGI:1924188
    See related
    Ensembl:ENSMUSG00000037197 AllianceGenome:MGI:1924188
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    2700027J02Rik
    Summary
    Predicted to enable RNA binding activity. Predicted to be involved in alternative mRNA splicing, via spliceosome. Located in nucleus. Part of protein-containing complex. Is expressed in brain; cerebral cortex; hippocampus; ovary; and primary sex cord. Orthologous to human RBM17 (RNA binding motif protein 17). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in CNS E11.5 (RPKM 55.4), CNS E14 (RPKM 34.1) and 25 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Rbm17 in Genome Data Viewer
    Location:
    2 A1; 2 8.85 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (11590250..11608061, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (11585439..11603199, complement)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene 6-phosphofructo-2-kinase/fructose-2,6-biphosphatase 3 Neighboring gene STARR-seq mESC enhancer starr_03667 Neighboring gene predicted gene, 52500 Neighboring gene STARR-seq mESC enhancer starr_03668 Neighboring gene predicted gene 10851 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11470208-11470361 Neighboring gene STARR-positive B cell enhancer mm9_chr2:11475523-11475823 Neighboring gene STARR-seq mESC enhancer starr_03673 Neighboring gene STARR-positive B cell enhancer ABC_E5883 Neighboring gene STARR-seq mESC enhancer starr_03674 Neighboring gene proteasome (prosome, macropain) 26S subunit, ATPase, 6 pseudogene Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11558884-11559067 Neighboring gene STARR-positive B cell enhancer ABC_E9504 Neighboring gene STARR-positive B cell enhancer ABC_E5884 Neighboring gene STARR-positive B cell enhancer ABC_E5885 Neighboring gene CapStarr-seq enhancer MGSCv37_chr2:11577075-11577258 Neighboring gene interleukin 2 receptor, alpha chain Neighboring gene STARR-seq mESC enhancer starr_03676 Neighboring gene predicted gene, 39760

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (3) 
    • Targeted (2)  1 citation

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables RNA binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in RNA splicing, via transesterification reactions TAS
    Traceable Author Statement
    more info
    PubMed 
    involved_in alternative mRNA splicing, via spliceosome IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in alternative mRNA splicing, via spliceosome ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in alternative mRNA splicing, via spliceosome ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in mRNA cis splicing, via spliceosome IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in nucleoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in nucleoplasm ISO
    Inferred from Sequence Orthology
    more info
     
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of protein-containing complex IDA
    Inferred from Direct Assay
    more info
    PubMed 
    part_of spliceosomal complex IEA
    Inferred from Electronic Annotation
    more info
     

    General protein information

    Preferred Names
    splicing factor 45
    Names
    45 kDa-splicing factor

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001418858.1NP_001405787.1  splicing factor 45 isoform 2

      Status: VALIDATED

      Source sequence(s)
      AL831794
    2. NM_001418859.1NP_001405788.1  splicing factor 45 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL831794
    3. NM_152824.2NP_690037.1  splicing factor 45 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL831794
      Consensus CDS
      CCDS15684.1
      UniProtKB/Swiss-Prot
      A2AP41, O75939, Q8JZX4
      Related
      ENSMUSP00000041831.6, ENSMUST00000040314.12
      Conserved Domains (2) summary
      cd12647
      Location:307401
      RRM_UHM_SPF45; RNA recognition motif in UHM domain of 45 kDa-splicing factor (SPF45) and similar proteins
      pfam01585
      Location:235275
      G-patch; G-patch domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      11590250..11608061 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    RNA

    1. XR_004940770.1 RNA Sequence