Awat1 acyl-CoA wax alcohol acyltransferase 1 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Awat1provided by MGI
Official Full Name: acyl-CoA wax alcohol acyltransferase 1provided by MGI
Primary source: MGI:MGI:3588200
See related: Ensembl:ENSMUSG00000015665 AllianceGenome:MGI:3588200
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Dgat2l3
Summary: Predicted to enable long-chain-alcohol O-fatty-acyltransferase activity. Predicted to be involved in lipid metabolic process. Predicted to be active in endoplasmic reticulum membrane. Orthologous to human AWAT1 (acyl-CoA wax alcohol acyltransferase 1). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Low expression observed in reference dataset See more
Orthologs: human all
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Genomic context

Location:: X C3; X 43.72 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	X	NC_000086.8 (99615853..99621812)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	X	NC_000086.7 (100572247..100578206)

Chromosome X - NC_000086.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The highest activity was observed for 14:0-CoA, 12:0-CoA, and 16:0-CoA in combination with medium chain alcohols (up to 5.2, 3.4, and 3.3 nmol wax esters/min/mg microsomal protein, respectively
Title: Detailed characterization of the substrate specificity of mouse wax synthase.

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3) 1 citation
Targeted (2)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables long-chain-alcohol O-fatty-acyltransferase activity	IBA Inferred from Biological aspect of Ancestor more info
enables long-chain-alcohol O-fatty-acyltransferase activity	IEA Inferred from Electronic Annotation more info
enables long-chain-alcohol O-fatty-acyltransferase activity	ISO Inferred from Sequence Orthology more info

Process	Evidence Code	Pubs
involved_in lipid metabolic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in lipid metabolic process	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
is_active_in endoplasmic reticulum membrane	IBA Inferred from Biological aspect of Ancestor more info
located_in endoplasmic reticulum membrane	IEA Inferred from Electronic Annotation more info

General protein information

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Preferred Names: acyl-CoA wax alcohol acyltransferase 1

Names: diacylglycerol O-acyltransferase 2-like protein 3; long-chain-alcohol O-fatty-acyltransferase 1; wax synthase 1

NP_001074605.1

EC 2.3.1.75

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.