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    Zfp935 zinc finger protein 935 [ Mus musculus (house mouse) ]

    Gene ID: 71508, updated on 27-Dec-2024

    Summary

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    Official Symbol
    Zfp935provided by MGI
    Official Full Name
    zinc finger protein 935provided by MGI
    Primary source
    MGI:MGI:1918758
    See related
    Ensembl:ENSMUSG00000113450 AllianceGenome:MGI:1918758
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Es113; Gm49359; 8430426H19Rik
    Summary
    Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleolus. Orthologous to several human genes including ZNF486 (zinc finger protein 486); ZNF506 (zinc finger protein 506); and ZNF679 (zinc finger protein 679). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in bladder adult (RPKM 2.6), placenta adult (RPKM 2.3) and 20 other tissues See more
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    Genomic context

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    See Zfp935 in Genome Data Viewer
    Location:
    13; 13 B3
    Exon count:
    4
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 13 NC_000079.7 (62600830..62614626, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 13 NC_000079.6 (62453016..62466852, complement)

    Chromosome 13 - NC_000079.7Genomic Context describing neighboring genes Neighboring gene predicted gene 3604 Neighboring gene STARR-seq mESC enhancer starr_34771 Neighboring gene selenoprotein K, pseudogene 6 Neighboring gene predicted gene, 53788 Neighboring gene STARR-positive B cell enhancer ABC_E7245 Neighboring gene predicted gene, 21145 Neighboring gene STARR-seq mESC enhancer starr_34772 Neighboring gene protein C1orf43 homolog Neighboring gene zinc finger protein 934

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Mouse brain organization revealed through direct genome-scale TF expression analysis. Gray PA, et al. Science, 2004 Dec 24. PMID 15618518
    2. BayGenomics: a resource of insertional mutations in mouse embryonic stem cells. Stryke D, et al. Nucleic Acids Res, 2003 Jan 1. PMID 12520002, Free PMC Article
    3. Large-scale gene trapping in C57BL/6N mouse embryonic stem cells. Hansen GM, et al. Genome Res, 2008 Oct. PMID 18799693, Free PMC Article
    4. A conditional knockout resource for the genome-wide study of mouse gene function. Skarnes WC, et al. Nature, 2011 Jun 15. PMID 21677750, Free PMC Article
    5. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    General gene information

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    Markers

    Homology

    Clone Names

    • MGC107309, MGC132990

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables RNA polymerase II cis-regulatory region sequence-specific DNA binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in biological_process ND
    No biological Data available
    more info
    		  
    involved_in regulation of transcription by RNA polymerase II IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cellular_component ND
    No biological Data available
    more info
    		  
    located_in nucleolus ISO
    Inferred from Sequence Orthology
    more info
    		  

    General protein information

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    Preferred Names
    KRAB zinc finger protein

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001136496.1 → NP_001129968.1  KRAB zinc finger protein isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) is missing an internal coding exon compared to transcript variant 1. This result in a frame-shift, and a shorter isoform (2) with a distinct C-terminus compared to isoform 1. Isoform 2 retains the 'KRAB' domain at the N-terminus.
      Source sequence(s)
      AK018441, BC087936
      Consensus CDS
      CCDS88469.1
      UniProtKB/TrEMBL
      A0A1Y7VP04
      Related
      ENSMUSP00000152739.2, ENSMUST00000223247.2
      Conserved Domains (2) summary
      smart00349
      Location:4 → 44
      KRAB; krueppel associated box
      pfam01352
      Location:4 → 40
      KRAB; KRAB box

    2. NM_178875.4 → NP_849206.2  KRAB zinc finger protein isoform 1

      See identical proteins and their annotated locations for NP_849206.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) encodes the longer isoform (1) containing the 'KRAB' domain at the N-terminus and the Zn-finger domain at the C-terminus.
      Source sequence(s)
      BC087936, BC113193
      Consensus CDS
      CCDS36697.1
      UniProtKB/TrEMBL
      Q14DI0
      Related
      ENSMUSP00000152662.2, ENSMUST00000221747.2
      Conserved Domains (5) summary
      smart00349
      Location:4 → 45
      KRAB; krueppel associated box
      COG5048
      Location:130 → 293
      COG5048; FOG: Zn-finger [General function prediction only]
      sd00017
      Location:219 → 239
      ZF_C2H2; C2H2 Zn finger [structural motif]
      pfam01352
      Location:4 → 40
      KRAB; KRAB box
      pfam13465
      Location:175 → 200
      zf-H2C2_2; Zinc-finger double domain

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000079.7 Reference GRCm39 C57BL/6J

      Range
      62600830..62614626 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version

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