U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    Fbxo10 F-box protein 10 [ Mus musculus (house mouse) ]

    Gene ID: 269529, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbxo10provided by MGI
    Official Full Name
    F-box protein 10provided by MGI
    Primary source
    MGI:MGI:2686937
    See related
    Ensembl:ENSMUSG00000048232 AllianceGenome:MGI:2686937
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    FBX10; Gm634
    Summary
    Predicted to be involved in regulation of apoptotic process and ubiquitin-dependent protein catabolic process. Predicted to be located in cytoplasm. Is expressed in cortical plate. Orthologous to human FBXO10 (F-box protein 10). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in genital fat pad adult (RPKM 21.2), ovary adult (RPKM 16.4) and 24 other tissues See more
    Orthologs
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    See Fbxo10 in Genome Data Viewer
    Location:
    4 B1; 4 23.68 cM
    Exon count:
    11
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 4 NC_000070.7 (45034248..45084555, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 4 NC_000070.6 (45034248..45084604, complement)

    Chromosome 4 - NC_000070.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700055D18 gene Neighboring gene CapStarr-seq enhancer MGSCv37_chr4:45025246-45025433 Neighboring gene STARR-positive B cell enhancer ABC_E71 Neighboring gene STARR-seq mESC enhancer starr_10090 Neighboring gene zinc finger and BTB domain containing 5 Neighboring gene polymerase (RNA) I polypeptide E Neighboring gene predicted gene, 30939 Neighboring gene STARR-seq mESC enhancer starr_10091 Neighboring gene translocase of outer mitochondrial membrane 5 Neighboring gene FERM and PDZ domain containing 1 Neighboring gene FERM and PDZ domain containing 1, opposite strand

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (6)  1 citation
    • Targeted (2) 

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Process Evidence Code Pubs
    involved_in apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in protein ubiquitination IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in regulation of apoptotic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in regulation of apoptotic process ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in ubiquitin-dependent protein catabolic process IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in ubiquitin-dependent protein catabolic process ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
     

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024142.2NP_001019313.1  F-box only protein 10 isoform 2

      See identical proteins and their annotated locations for NP_001019313.1

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Consensus CDS
      CCDS51171.1
      UniProtKB/Swiss-Prot
      A2ANI6, Q6AXG0, Q7TQF2, Q7TQM0
      UniProtKB/TrEMBL
      Q505G2
      Related
      ENSMUSP00000058233.7, ENSMUST00000052236.13
      Conserved Domains (2) summary
      pfam12937
      Location:650
      F-box-like; F-box-like
      pfam13229
      Location:460606
      Beta_helix; Right handed beta helix region
    2. NM_001378819.1NP_001365748.1  F-box only protein 10 isoform 1

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (2) summary
      pfam12937
      Location:649
      F-box-like
      pfam13229
      Location:460616
      Beta_helix; Right handed beta helix region
    3. NM_001378820.1NP_001365749.1  F-box only protein 10 isoform 3

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (1) summary
      pfam13229
      Location:273419
      Beta_helix; Right handed beta helix region
    4. NM_001378821.1NP_001365750.1  F-box only protein 10 isoform 4

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (2) summary
      pfam12937
      Location:649
      F-box-like
      pfam13229
      Location:460606
      Beta_helix; Right handed beta helix region
    5. NM_001378822.1NP_001365751.1  F-box only protein 10 isoform 5

      Status: VALIDATED

      Source sequence(s)
      AL824706
      Conserved Domains (2) summary
      pfam12937
      Location:649
      F-box-like
      pfam13229
      Location:460616
      Beta_helix; Right handed beta helix region
    6. NM_001378823.1NP_001365752.1  F-box only protein 10 isoform 6

      Status: VALIDATED

      Source sequence(s)
      AL824706
      UniProtKB/TrEMBL
      Q505G2
      Related
      ENSMUSP00000119862.2, ENSMUST00000140008.2
      Conserved Domains (1) summary
      pfam13229
      Location:273419
      Beta_helix; Right handed beta helix region

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000070.7 Reference GRCm39 C57BL/6J

      Range
      45034248..45084555 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)