Asb14 ankyrin repeat and SOCS box-containing 14 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Asb14provided by MGI
Official Full Name: ankyrin repeat and SOCS box-containing 14provided by MGI
Primary source: MGI:MGI:2655107
See related: Ensembl:ENSMUSG00000021898 AllianceGenome:MGI:2655107
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Asb-14
Summary: Predicted to be involved in intracellular signal transduction and protein ubiquitination. Orthologous to human ASB14 (ankyrin repeat and SOCS box containing 14). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Biased expression in heart adult (RPKM 27.4) and mammary gland adult (RPKM 3.1) See more
Orthologs: human all
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Location:: 14 A3; 14 16.09 cM

Exon count:: 11

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (26616547..26638393)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (26894590..26915257)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

Go to the top of the page Help

See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.
Title: E3 Ubiquitin Ligase ASB14 Inhibits Cardiomyocyte Proliferation by Regulating MAPRE2 Ubiquitination.

Submit: New GeneRIF Correction

Variation

Go to the top of the page Help

Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (1)

General gene information

Go to the top of the page Help

Markers

NoName (e-PCR)
- UniSTS:488251

NoName (e-PCR)
- UniSTS:495432

Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
involved_in biological_process	ND No biological Data available more info
involved_in intracellular signal transduction	IEA Inferred from Electronic Annotation more info
involved_in protein ubiquitination	IEA Inferred from Electronic Annotation more info

General protein information

Go to the top of the page Help

Preferred Names: ankyrin repeat and SOCS box protein 14

Names: ankyrin repeat and SOCS box-containing protein 14; ankyrin repeat domain-containing SOCS box protein 14

NCBI Reference Sequences (RefSeq)

Go to the top of the page Help

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_001170748.2 → NP_001164219.2 ankyrin repeat and SOCS box protein 14 isoform 1

Status: VALIDATED

Description

Transcript Variant: This variant (1) represents the longer transcript and encodes the longer isoform (1).

Source sequence(s)

AK052884, BC145002

Consensus CDS

CCDS49431.2

UniProtKB/Swiss-Prot

B7ZN45, Q8C6Y6, Q8VHS7

UniProtKB/TrEMBL

A0A5F8MPW7

Related

ENSMUSP00000159151.2, ENSMUST00000238987.2

Conserved Domains (4) summary

PHA02875
Location:116 → 343

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:182 → 213

ANK; ANK repeat [structural motif]

pfam12796
Location:319 → 413

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:529 → 585

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
NM_080856.5 → NP_543132.4 ankyrin repeat and SOCS box protein 14 isoform 2

Status: VALIDATED

Description

Transcript Variant: This variant (2) uses an alternate 3' splice pattern, compared to variant 1. The resulting isoform (2) has a shorter and distinct C-terminus, compared to isoform 1.

Source sequence(s)

AK052884

Consensus CDS

CCDS36842.3

UniProtKB/Swiss-Prot

B7ZN45, Q8C6Y6, Q8VHS7

UniProtKB/TrEMBL

A0A5F8MPK4

Related

ENSMUSP00000159012.2, ENSMUST00000239004.2

Conserved Domains (3) summary

PHA02875
Location:116 → 343

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:182 → 213

ANK; ANK repeat [structural motif]

pfam12796
Location:319 → 413

Ank_2; Ankyrin repeats (3 copies)

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000080.7 Reference GRCm39 C57BL/6J

Range

26616547..26638393

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006518555.5 → XP_006518618.1 ankyrin repeat and SOCS box protein 14 isoform X1

UniProtKB/Swiss-Prot

B7ZN45, Q8C6Y6, Q8VHS7

Conserved Domains (4) summary

PHA02875
Location:145 → 372

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:211 → 242

ANK; ANK repeat [structural motif]

pfam12796
Location:348 → 442

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:558 → 614

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_011244955.3 → XP_011243257.1 ankyrin repeat and SOCS box protein 14 isoform X2

See identical proteins and their annotated locations for XP_011243257.1

UniProtKB/Swiss-Prot

B7ZN45, Q8C6Y6, Q8VHS7

Conserved Domains (4) summary

PHA02875
Location:15 → 242

PHA02875; ankyrin repeat protein; Provisional

sd00045
Location:81 → 112

ANK; ANK repeat [structural motif]

pfam12796
Location:218 → 312

Ank_2; Ankyrin repeats (3 copies)

cl02533
Location:428 → 484

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...
XM_036158465.1 → XP_036014358.1 ankyrin repeat and SOCS box protein 14 isoform X3

Conserved Domains (3) summary

sd00045
Location:18 → 49

ANK; ANK repeat [structural motif]

cl02533
Location:365 → 421

SOCS; SOCS (suppressors of cytokine signaling) box. The SOCS box is found in the C-terminal region of CIS/SOCS family proteins (in combination with a SH2 domain), ASBs (ankyrin repeat-containing proteins with a SOCS box), SSBs (SPRY domain-containing proteins ...

cl39094
Location:5 → 253

Ank_2; Ankyrin repeats (3 copies)