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    Ovca2 candidate tumor suppressor in ovarian cancer 2 [ Mus musculus (house mouse) ]

    Gene ID: 246257, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Ovca2provided by MGI
    Official Full Name
    candidate tumor suppressor in ovarian cancer 2provided by MGI
    Primary source
    MGI:MGI:2179725
    See related
    Ensembl:ENSMUSG00000038268 AllianceGenome:MGI:2179725
    Gene type
    protein coding
    RefSeq status
    PROVISIONAL
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    9030414M07Rik
    Summary
    Predicted to enable hydrolase activity. Predicted to be involved in response to retinoic acid. Located in cytoplasm and nucleus. Orthologous to human OVCA2 (OVCA2 serine hydrolase domain containing). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Ubiquitous expression in ovary adult (RPKM 12.2), kidney adult (RPKM 10.4) and 28 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Ovca2 in Genome Data Viewer
    Location:
    11 B5; 11 45.76 cM
    Exon count:
    2
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 11 NC_000077.7 (75066769..75069634, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 11 NC_000077.6 (75175943..75178808, complement)

    Chromosome 11 - NC_000077.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 1700016P03 gene Neighboring gene microRNA 212 Neighboring gene microRNA 132 Neighboring gene STARR-positive B cell enhancer ABC_E7016 Neighboring gene diphthamide biosynthesis 1 Neighboring gene reticulon 4 receptor-like 1 Neighboring gene STARR-seq mESC enhancer starr_29983 Neighboring gene STARR-seq mESC enhancer starr_29985 Neighboring gene STARR-seq mESC enhancer starr_29986 Neighboring gene predicted gene, 35169 Neighboring gene predicted gene, 35117

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Expression

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    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

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    Related articles in PubMed

    1. Cloning, structure, and expression of the mouse Ovca1 gene. Chen CM, et al. Biochem Biophys Res Commun, 2001 Sep 7. PMID 11527402
    2. A hybrid photoreceptor expressing both rod and cone genes in a mouse model of enhanced S-cone syndrome. Corbo JC, et al. PLoS Genet, 2005 Aug. PMID 16110338, Free PMC Article
    3. Libraries enriched for alternatively spliced exons reveal splicing patterns in melanocytes and melanomas. Watahiki A, et al. Nat Methods, 2004 Dec. PMID 15782199
    4. Wnk1 kinase deficiency lowers blood pressure in mice: a gene-trap screen to identify potential targets for therapeutic intervention. Zambrowicz BP, et al. Proc Natl Acad Sci U S A, 2003 Nov 25. PMID 14610273, Free PMC Article
    5. A high-resolution anatomical atlas of the transcriptome in the mouse embryo. Diez-Roux G, et al. PLoS Biol, 2011 Jan 18. PMID 21267068, Free PMC Article

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Gene trapped (1) 

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables hydrolase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables hydrolase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables molecular_function ND
    No biological Data available
    more info
    		  
    Process Evidence Code Pubs
    involved_in response to retinoic acid IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in response to retinoic acid ISO
    Inferred from Sequence Orthology
    more info
    		  
    Component Evidence Code Pubs
    is_active_in cytoplasm IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    esterase OVCA2
    Names
    candidate tumor suppressor OVCA2
    ortholog of human candidate tumor suppressor in ovarian cancer 2 OVCA2
    ovarian cancer-associated gene 2 protein homolog
    NP_081412.1

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_027136.3 → NP_081412.1  esterase OVCA2

      Status: PROVISIONAL

      Source sequence(s)
      AL603905
      Consensus CDS
      CCDS25041.1
      UniProtKB/Swiss-Prot
      Q9D7E3
      Related
      ENSMUSP00000071493.3, ENSMUST00000071562.3
      Conserved Domains (1) summary
      pfam03959
      Location:6 → 216
      FSH1; Serine hydrolase (FSH1)

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000077.7 Reference GRCm39 C57BL/6J

      Range
      75066769..75069634 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9D7E3.1 GenPept UniProtKB/Swiss-Prot:Q9D7E3

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Chemical Information
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