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    Defa4 defensin, alpha, 4 [ Mus musculus (house mouse) ]

    Gene ID: 13238, updated on 9-Dec-2024

    Summary

    Official Symbol
    Defa4provided by MGI
    Official Full Name
    defensin, alpha, 4provided by MGI
    Primary source
    MGI:MGI:99584
    See related
    AllianceGenome:MGI:99584
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Crp4; Defa28; Defcr4
    Summary
    Enables phospholipid binding activity. Involved in killing of cells of another organism. Acts upstream of or within antibacterial humoral response and disruption of plasma membrane integrity in another organism. Located in extracellular space. Is expressed in duodenum and ileum. Orthologous to several human genes including DEFA6 (defensin alpha 6). [provided by Alliance of Genome Resources, Dec 2024]
    Annotation information
    not in current annotation release
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    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    General gene information

    Gene Ontology Provided by MGI

    Component Evidence Code Pubs
    located_in azurophil granule  
    is_active_in extracellular space  
    located_in extracellular space PubMed 
    located_in extracellular space  
    located_in transport vesicle  

    General protein information

    Preferred Names
    defensin alpha 4
    Names
    alpha-defensin 4
    alpha-defensin, 28
    defensin related cryptdin 4

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010039.2NP_034169.2  defensin alpha 4 precursor

      See identical proteins and their annotated locations for NP_034169.2

      Status: VALIDATED

      Source sequence(s)
      BC134360, BX634116
      UniProtKB/Swiss-Prot
      A3KPC1, P28311, Q9QZL4
      Conserved Domains (2) summary
      pfam00323
      Location:6489
      Defensin_1; Mammalian defensin
      pfam00879
      Location:1551
      Defensin_propep; Defensin propeptide
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