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    Kif11 kinesin family member 11 [ Mus musculus (house mouse) ]

    Gene ID: 16551, updated on 9-Dec-2024

    Summary

    Official Symbol
    Kif11provided by MGI
    Official Full Name
    kinesin family member 11provided by MGI
    Primary source
    MGI:MGI:1098231
    See related
    Ensembl:ENSMUSG00000012443 AllianceGenome:MGI:1098231
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Eg5; Kif8; Kifl1; Knsl1
    Summary
    Predicted to enable plus-end-directed microtubule motor activity and protein kinase binding activity. Acts upstream of or within mitotic centrosome separation and spindle assembly. Predicted to be located in cytosol; microtubule; and spindle. Predicted to be part of protein-containing complex. Predicted to be active in mitotic spindle; nucleus; and spindle microtubule. Predicted to colocalize with spindle pole. Is expressed in several structures, including alimentary system; genitourinary system; nervous system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in microcephaly with or without chorioretinopathy, lymphedema, or mental retardation. Orthologous to human KIF11 (kinesin family member 11). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in CNS E11.5 (RPKM 30.5), liver E14 (RPKM 27.0) and 10 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Kif11 in Genome Data Viewer
    Location:
    19 C2; 19 32.27 cM
    Exon count:
    22
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 19 NC_000085.7 (37364830..37410311)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 19 NC_000085.6 (37376382..37421863)

    Chromosome 19 - NC_000085.7Genomic Context describing neighboring genes Neighboring gene RIKEN cDNA 4931408D14 gene Neighboring gene STARR-positive B cell enhancer ABC_E8748 Neighboring gene insulin degrading enzyme Neighboring gene ribosomal protein L10, pseudogene 6 Neighboring gene STARR-seq mESC enhancer starr_46050 Neighboring gene STARR-positive B cell enhancer ABC_E7648 Neighboring gene CapStarr-seq enhancer MGSCv37_chr19:37444922-37445105 Neighboring gene STARR-seq mESC enhancer starr_46052 Neighboring gene STARR-positive B cell enhancer ABC_E7649 Neighboring gene STARR-positive B cell enhancer ABC_E11674 Neighboring gene STARR-seq mESC enhancer starr_46054 Neighboring gene mortality factor 4 like 1 pseudogene Neighboring gene predicted gene, 46649 Neighboring gene hematopoietically expressed homeobox Neighboring gene RIKEN cDNA 1700122C19 gene

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables ATP binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables microtubule motor activity IEA
    Inferred from Electronic Annotation
    more info
     
    enables plus-end-directed microtubule motor activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein kinase binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein kinase binding ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in cell division IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in microtubule-based movement IEA
    Inferred from Electronic Annotation
    more info
     
    acts_upstream_of_or_within mitotic centrosome separation IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in mitotic spindle assembly IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in mitotic spindle assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in mitotic spindle assembly ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    involved_in regulation of mitotic centrosome separation ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in regulation of mitotic centrosome separation ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    acts_upstream_of_or_within spindle assembly IMP
    Inferred from Mutant Phenotype
    more info
    PubMed 
    involved_in spindle elongation IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    involved_in spindle organization ISO
    Inferred from Sequence Orthology
    more info
     
    Component Evidence Code Pubs
    located_in cytosol IEA
    Inferred from Electronic Annotation
    more info
     
    located_in cytosol ISO
    Inferred from Sequence Orthology
    more info
     
    located_in microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    is_active_in mitotic spindle IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in mitotic spindle IEA
    Inferred from Electronic Annotation
    more info
     
    located_in mitotic spindle ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in nucleus IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    part_of protein-containing complex IEA
    Inferred from Electronic Annotation
    more info
     
    part_of protein-containing complex ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    is_active_in spindle microtubule IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in spindle microtubule IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with spindle microtubule ISO
    Inferred from Sequence Orthology
    more info
     
    located_in spindle pole IEA
    Inferred from Electronic Annotation
    more info
     
    colocalizes_with spindle pole ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    kinesin-like protein KIF11
    Names
    kinesin-like 1
    kinesin-related motor protein Eg5

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_010615.2NP_034745.1  kinesin-like protein KIF11

      See identical proteins and their annotated locations for NP_034745.1

      Status: VALIDATED

      Source sequence(s)
      BC060670, BY097786, CJ206639
      Consensus CDS
      CCDS29777.1
      UniProtKB/Swiss-Prot
      Q6P9P6, Q9Z1J0
      Related
      ENSMUSP00000012587.4, ENSMUST00000012587.4
      Conserved Domains (3) summary
      smart00129
      Location:17365
      KISc; Kinesin motor, catalytic domain. ATPase
      cd01364
      Location:15367
      KISc_BimC_Eg5; Kinesin motor domain, BimC/Eg5 spindle pole proteins
      pfam13931
      Location:9151047
      Microtub_bind; Kinesin-associated microtubule-binding

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000085.7 Reference GRCm39 C57BL/6J

      Range
      37364830..37410311
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)