Dnajc15 DnaJ heat shock protein family (Hsp40) member C15 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Dnajc15provided by MGI
Official Full Name: DnaJ heat shock protein family (Hsp40) member C15provided by MGI
Primary source: MGI:MGI:1913398
See related: Ensembl:ENSMUSG00000022013 AllianceGenome:MGI:1913398
Gene type: protein coding
RefSeq status: PROVISIONAL
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: MCJ; Dnajd1; 1110003P16Rik
Summary: Predicted to enable ATPase activator activity. Acts upstream of or within several processes, including cellular response to starvation; negative regulation of mitochondrial electron transport, NADH to ubiquinone; and negative regulation of protein-containing complex assembly. Located in mitochondrial inner membrane. Is expressed in endocrine gland; genitourinary system; heart; and nervous system. Orthologous to human DNAJC15 (DnaJ heat shock protein family (Hsp40) member C15). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Broad expression in testis adult (RPKM 177.3), ovary adult (RPKM 65.1) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 14 D3; 14 41.04 cM

Exon count:: 6

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	14	NC_000080.7 (78063657..78112357, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	14	NC_000080.6 (77826217..77874917, complement)

Chromosome 14 - NC_000080.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

Go to nucleotide: Graphics FASTA GenBank

Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis.
Title: The mitochondrial negative regulator MCJ modulates the interplay between microbiota and the host during ulcerative colitis.
Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation.
Title: Silencing hepatic MCJ attenuates non-alcoholic fatty liver disease (NAFLD) by increasing mitochondrial fatty acid oxidation.
In vivo treatment with an inhibitor of MCJ expression protects liver from acetaminophen-induced liver injury in mouse model at a time when N-acetylcysteine, the standard therapy, has no efficacy. Acetaminophen-induced liver injury progresses through the central participation of MCJ in vitro and in vivo.
Title: The mitochondrial negative regulator MCJ is a therapeutic target for acetaminophen-induced liver injury.
DNAJC15 localizes at the mitochondrial inner membrane, where it interacts preferentially with complex I of the electron transfer chain.DnaJC15 functions as a negative regulator of mitochondrial membrane potential and ATP production.
Title: MCJ/DnaJC15, an endogenous mitochondrial repressor of the respiratory chain that controls metabolic alterations.

Submit: New GeneRIF Correction

Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (3)
Gene trapped (1)
Targeted (3)

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables ATPase activator activity	IBA Inferred from Biological aspect of Ancestor more info
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within cellular response to starvation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of mitochondrial electron transport, NADH to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of mitochondrial electron transport, NADH to ubiquinone	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in protein import into mitochondrial matrix	IBA Inferred from Biological aspect of Ancestor more info
involved_in protein transport	IEA Inferred from Electronic Annotation more info
acts_upstream_of protein-containing complex assembly	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of lipid metabolic process	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of PAM complex, Tim23 associated import motor	IBA Inferred from Biological aspect of Ancestor more info
located_in mitochondrial inner membrane	IDA Inferred from Direct Assay more info	PubMed
located_in mitochondrion	HDA more info	PubMed
located_in mitochondrion	IDA Inferred from Direct Assay more info	PubMed

General protein information

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Preferred Names: dnaJ homolog subfamily C member 15

Names: DnaJ (Hsp40) homolog, subfamily C, member 15; DnaJ (Hsp40) homolog, subfamily D, member 1

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025384.3 → NP_079660.1 dnaJ homolog subfamily C member 15

See identical proteins and their annotated locations for NP_079660.1

Status: PROVISIONAL

Source sequence(s)

BC027509

Consensus CDS

CCDS27292.1

UniProtKB/Swiss-Prot

Q78YY6

Related

ENSMUSP00000154390.2, ENSMUST00000226459.2

Conserved Domains (1) summary

cl02542
Location:85 → 142

DnaJ; DnaJ domain or J-domain. DnaJ/Hsp40 (heat shock protein 40) proteins are highly conserved and play crucial roles in protein translation, folding, unfolding, translocation, and degradation. They act primarily by stimulating the ATPase activity of Hsp70s, ...