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    Qsox1 quiescin Q6 sulfhydryl oxidase 1 [ Mus musculus (house mouse) ]

    Gene ID: 104009, updated on 9-Dec-2024

    Summary

    Official Symbol
    Qsox1provided by MGI
    Official Full Name
    quiescin Q6 sulfhydryl oxidase 1provided by MGI
    Primary source
    MGI:MGI:1330818
    See related
    Ensembl:ENSMUSG00000033684 AllianceGenome:MGI:1330818
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    SOx; QSOX; Qscn6; b2b2673Clo; 1300003H02Rik
    Summary
    Predicted to enable FAD binding activity; flavin-dependent sulfhydryl oxidase activity; and protein disulfide isomerase activity. Predicted to be involved in extracellular matrix assembly; negative regulation of macroautophagy; and protein folding. Located in extracellular space. Is expressed in several structures, including alimentary system; cardiovascular system; nervous system; respiratory system; and skin. Used to study VACTERL association. Orthologous to human QSOX1 (quiescin sulfhydryl oxidase 1). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in liver adult (RPKM 148.9), liver E18 (RPKM 139.0) and 21 other tissues See more
    Orthologs
    NEW
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    Genomic context

    See Qsox1 in Genome Data Viewer
    Location:
    1 G3; 1 67.64 cM
    Exon count:
    12
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 1 NC_000067.7 (155653901..155688645, complement)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 1 NC_000067.6 (155778155..155812899, complement)

    Chromosome 1 - NC_000067.7Genomic Context describing neighboring genes Neighboring gene CapStarr-seq enhancer MGSCv37_chr1:157405138-157405321 Neighboring gene STARR-positive B cell enhancer ABC_E9484 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157423836-157424136 Neighboring gene acyl-Coenzyme A binding domain containing 6 Neighboring gene STARR-seq mESC enhancer starr_02727 Neighboring gene LIM homeobox protein 4 Neighboring gene STARR-positive B cell enhancer mm9_chr1:157659814-157660115 Neighboring gene centrosomal protein 350 Neighboring gene predicted gene, 36934 Neighboring gene predicted gene, 51652

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Chemically induced (ENU) (1) 
    • Endonuclease-mediated (4) 
    • Targeted (1) 

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables FAD binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables FAD binding ISO
    Inferred from Sequence Orthology
    more info
     
    enables flavin-dependent sulfhydryl oxidase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables flavin-dependent sulfhydryl oxidase activity ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    enables flavin-dependent sulfhydryl oxidase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    enables protein disulfide isomerase activity IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    enables protein disulfide isomerase activity ISO
    Inferred from Sequence Orthology
    more info
     
    enables protein disulfide isomerase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    Process Evidence Code Pubs
    involved_in extracellular matrix assembly IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in extracellular matrix assembly ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in negative regulation of macroautophagy IEA
    Inferred from Electronic Annotation
    more info
     
    involved_in negative regulation of macroautophagy ISO
    Inferred from Sequence Orthology
    more info
     
    involved_in protein folding IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    Component Evidence Code Pubs
    located_in Golgi apparatus ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    is_active_in Golgi membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in Golgi membrane ISO
    Inferred from Sequence Orthology
    more info
     
    located_in Golgi membrane ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in endoplasmic reticulum ISO
    Inferred from Sequence Orthology
    more info
    PubMed 
    located_in extracellular exosome IEA
    Inferred from Electronic Annotation
    more info
     
    located_in extracellular exosome ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space HDA PubMed 
    is_active_in extracellular space IBA
    Inferred from Biological aspect of Ancestor
    more info
     
    located_in extracellular space ISO
    Inferred from Sequence Orthology
    more info
     
    located_in extracellular space ISS
    Inferred from Sequence or Structural Similarity
    more info
     
    located_in intercellular bridge IEA
    Inferred from Electronic Annotation
    more info
     
    located_in intercellular bridge ISO
    Inferred from Sequence Orthology
    more info
     
    located_in intracellular membrane-bounded organelle ISO
    Inferred from Sequence Orthology
    more info
     

    General protein information

    Preferred Names
    sulfhydryl oxidase 1
    Names
    skin sulfhydryl oxidase
    NP_001020116.1
    NP_075757.1

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001024945.1NP_001020116.1  sulfhydryl oxidase 1 isoform a precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longer transcript and encodes the longer protein (isoform a).
      Source sequence(s)
      AK083938, BY334148, CK625426
      Consensus CDS
      CCDS15386.1
      UniProtKB/Swiss-Prot
      Q3TDY9, Q3TE19, Q3TR29, Q3UEL4, Q8BND5, Q8K041, Q9DBL6
      Related
      ENSMUSP00000035658.9, ENSMUST00000035325.15
      Conserved Domains (2) summary
      cd02992
      Location:43155
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:409501
      Evr1_Alr; Erv1 / Alr family
    2. NM_023268.2NP_075757.1  sulfhydryl oxidase 1 isoform b precursor

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) uses an alternate splice site in the 3' coding region compared to variant 1. The resulting protein (isoform b) is shorter and has a distinct C-terminus compared to isoform a.
      Source sequence(s)
      AB044284, AK083938, BY334148, CK625426
      Consensus CDS
      CCDS78713.1
      UniProtKB/Swiss-Prot
      Q8BND5
      Related
      ENSMUSP00000142301.2, ENSMUST00000194632.2
      Conserved Domains (2) summary
      cd02992
      Location:43155
      PDI_a_QSOX; PDIa family, Quiescin-sulfhydryl oxidase (QSOX) subfamily; QSOX is a eukaryotic protein containing an N-terminal redox active TRX domain, similar to that of PDI, and a small C-terminal flavin adenine dinucleotide (FAD)-binding domain homologous to the ...
      pfam04777
      Location:409501
      Evr1_Alr; Erv1 / Alr family

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000067.7 Reference GRCm39 C57BL/6J

      Range
      155653901..155688645 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)