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    Fbln7 fibulin 7 [ Mus musculus (house mouse) ]

    Gene ID: 70370, updated on 9-Dec-2024

    Summary

    Official Symbol
    Fbln7provided by MGI
    Official Full Name
    fibulin 7provided by MGI
    Primary source
    MGI:MGI:1917620
    See related
    Ensembl:ENSMUSG00000027386 AllianceGenome:MGI:1917620
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    TM14; 1600015H20Rik
    Summary
    Enables heparan sulfate proteoglycan binding activity and heparin binding activity. Predicted to be involved in cell adhesion. Located in extracellular matrix and extracellular space. Is expressed in several structures, including alimentary system; brain; reproductive system; respiratory system; and skeleton. Orthologous to human FBLN7 (fibulin 7). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Broad expression in placenta adult (RPKM 6.7), kidney adult (RPKM 6.3) and 19 other tissues See more
    Orthologs
    NEW
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    Try the new Transcript table

    Genomic context

    See Fbln7 in Genome Data Viewer
    Location:
    2 F1; 2 62.63 cM
    Exon count:
    8
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 2 NC_000068.8 (128705791..128738954)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 2 NC_000068.7 (128863865..128897034)

    Chromosome 2 - NC_000068.8Genomic Context describing neighboring genes Neighboring gene predicted gene, 39931 Neighboring gene VISTA enhancer mm1476 Neighboring gene MER proto-oncogene tyrosine kinase Neighboring gene STARR-seq mESC enhancer starr_05650 Neighboring gene STARR-seq mESC enhancer starr_05651 Neighboring gene STARR-positive B cell enhancer ABC_E2046 Neighboring gene transmembrane protein 87B Neighboring gene STARR-seq mESC enhancer starr_05654 Neighboring gene STARR-positive B cell enhancer ABC_E7861 Neighboring gene STARR-positive B cell enhancer ABC_E3403 Neighboring gene zinc finger CCCH type containing 8 Neighboring gene predicted gene 14028

    Genomic regions, transcripts, and products

    Expression

    • Project title: Mouse ENCODE transcriptome data
    • Description: RNA profiling data sets generated by the Mouse ENCODE project.
    • BioProject: PRJNA66167
    • Publication: PMID 25409824
    • Analysis date: n/a

    Bibliography

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?

    Variation

    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)
    • Endonuclease-mediated (2) 
    • Gene trapped (1) 
    • Targeted (5)  1 citation

    Interactions

    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Markers

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables calcium ion binding IEA
    Inferred from Electronic Annotation
    more info
     
    enables heparan sulfate proteoglycan binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    enables heparin binding IDA
    Inferred from Direct Assay
    more info
    PubMed 
    Process Evidence Code Pubs
    involved_in cell adhesion IEA
    Inferred from Electronic Annotation
    more info
     
    Component Evidence Code Pubs
    located_in extracellular matrix IDA
    Inferred from Direct Assay
    more info
    PubMed 
    located_in extracellular space IDA
    Inferred from Direct Assay
    more info
    PubMed 

    General protein information

    Preferred Names
    fibulin-7
    Names
    FIBL-7
    extracellular matrix protein TM14

    NCBI Reference Sequences (RefSeq)

    NEW Try the new Transcript table

    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_024237.4NP_077199.2  fibulin-7 precursor

      See identical proteins and their annotated locations for NP_077199.2

      Status: VALIDATED

      Source sequence(s)
      AL808104, BB867118, BM936626, BX520805, CK023294
      Consensus CDS
      CCDS38235.1
      UniProtKB/Swiss-Prot
      Q501P1, Q9DAW5
      Related
      ENSMUSP00000028864.3, ENSMUST00000028864.3
      Conserved Domains (5) summary
      cd00033
      Location:81135
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00054
      Location:136172
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:271308
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:251274
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:221268
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000068.8 Reference GRCm39 C57BL/6J

      Range
      128705791..128738954
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_006500157.5XP_006500220.1  fibulin-7 isoform X1

      Conserved Domains (5) summary
      cd00033
      Location:81135
      CCP; Complement control protein (CCP) modules (aka short consensus repeats SCRs or SUSHI repeats) have been identified in several proteins of the complement system
      cd00054
      Location:136172
      EGF_CA; Calcium-binding EGF-like domain, present in a large number of membrane-bound and extracellular (mostly animal) proteins. Many of these proteins require calcium for their biological function and calcium-binding sites have been found to be located at the ...
      pfam07645
      Location:271308
      EGF_CA; Calcium-binding EGF domain
      pfam12662
      Location:251274
      cEGF; Complement Clr-like EGF-like
      cl00057
      Location:221268
      vWFA; Von Willebrand factor type A (vWA) domain was originally found in the blood coagulation protein von Willebrand factor (vWF). Typically, the vWA domain is made up of approximately 200 amino acid residues folded into a classic a/b para-rossmann type of ...