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    Dlg2 discs large MAGUK scaffold protein 2 [ Mus musculus (house mouse) ]

    Gene ID: 23859, updated on 9-Dec-2024

    Summary

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    Official Symbol
    Dlg2provided by MGI
    Official Full Name
    discs large MAGUK scaffold protein 2provided by MGI
    Primary source
    MGI:MGI:1344351
    See related
    Ensembl:ENSMUSG00000052572 AllianceGenome:MGI:1344351
    Gene type
    protein coding
    RefSeq status
    VALIDATED
    Organism
    Mus musculus
    Lineage
    Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
    Also known as
    Dlgh2; PSD93; Gm1197; Gm21505; A330103J02Rik; B230218P12Rik; B330007M19Rik
    Summary
    A structural constituent of postsynaptic density. Involved in several processes, including axo-dendritic protein transport; clustering of voltage-gated potassium channels; and neurotransmitter receptor localization to postsynaptic specialization membrane. Acts upstream of or within chemical synaptic transmission and sensory perception of pain. Located in several cellular components, including juxtaparanode region of axon; postsynaptic membrane; and synaptic vesicle membrane. Is active in axon initial segment and glutamatergic synapse. Is expressed in jaw bone; nervous system; and retina. Orthologous to human DLG2 (discs large MAGUK scaffold protein 2). [provided by Alliance of Genome Resources, Dec 2024]
    Expression
    Biased expression in frontal lobe adult (RPKM 12.3), cortex adult (RPKM 11.4) and 5 other tissues See more
    Orthologs
    human all
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    Genomic context

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    See Dlg2 in Genome Data Viewer
    Location:
    7 E1; 7 51.07 cM
    Exon count:
    40
    Annotation release Status Assembly Chr Location
    RS_2024_02 current GRCm39 (GCF_000001635.27) 7 NC_000073.7 (90125399..92098454)
    108.20200622 previous assembly GRCm38.p6 (GCF_000001635.26) 7 NC_000073.6 (90476188..92449246)

    Chromosome 7 - NC_000073.7Genomic Context describing neighboring genes Neighboring gene STARR-positive B cell enhancer ABC_E352 Neighboring gene STARR-seq mESC enhancer starr_19512 Neighboring gene STARR-seq mESC enhancer starr_19513 Neighboring gene transmembrane protein 126A Neighboring gene transmembrane protein 126B Neighboring gene STARR-seq mESC enhancer starr_19514 Neighboring gene STARR-seq mESC enhancer starr_19515 Neighboring gene predicted gene, 57513 Neighboring gene high mobility group protein B1 pseudogene Neighboring gene predicted gene, 39048 Neighboring gene STARR-seq mESC enhancer starr_19518 Neighboring gene STARR-seq mESC enhancer starr_19519 Neighboring gene predicted gene, 24552 Neighboring gene STARR-seq mESC enhancer starr_19520 Neighboring gene STARR-seq mESC enhancer starr_19521 Neighboring gene STARR-seq mESC enhancer starr_19522 Neighboring gene STARR-seq mESC enhancer starr_19523 Neighboring gene predicted gene, 23928 Neighboring gene RIKEN cDNA 4930567K12 gene Neighboring gene predicted gene, 32353 Neighboring gene predicted gene, 53382 Neighboring gene STARR-seq mESC enhancer starr_19525 Neighboring gene predicted gene, 31491 Neighboring gene coiled-coil domain containing 90B Neighboring gene ankyrin repeat domain 42

    Genomic regions, transcripts, and products

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    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. PSD-93 knock-out mice reveal that neuronal MAGUKs are not required for development or function of parallel fiber synapses in cerebellum. McGee AW, et al. J Neurosci, 2001 May 1. PMID 11312293, Free PMC Article
    2. PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice. Zhang Q, et al. Transl Stroke Res, 2020 Oct. PMID 32130656
    3. The Effect of PSD-93 Deficiency on the Expression of Early Inflammatory Cytokines Induced by Ischemic Brain Injury. Zhang Q, et al. Cell Biochem Biophys, 2015 Dec. PMID 27259312
    4. Proteomic analysis of PSD-93 knockout mice following the induction of ischemic cerebral injury. Rong R, et al. Neurotoxicology, 2016 Mar. PMID 26680505
    5. Differential roles of postsynaptic density-93 isoforms in regulating synaptic transmission. Krüger JM, et al. J Neurosci, 2013 Sep 25. PMID 24068818, Free PMC Article

    See all (100) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2.
      Title: Selective behavioural impairments in mice heterozygous for the cross disorder psychiatric risk gene DLG2.
    2. MAGUKs are essential, but redundant, in long-term potentiation.
      Title: MAGUKs are essential, but redundant, in long-term potentiation.
    3. PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1.
      Title: PSD-93 mediates the crosstalk between neuron and microglia and facilitates acute ischemic stroke injury by binding to CX3CL1.
    4. PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice.
      Title: PSD-93 Interacts with SynGAP and Promotes SynGAP Ubiquitination and Ischemic Brain Injury in Mice.
    5. A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum.
      Title: A DLG2 deficiency in mice leads to reduced sociability and increased repetitive behavior accompanied by aberrant synaptic transmission in the dorsal striatum.
    6. PIP3-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
      Title: PIP(3)-Phldb2 is crucial for LTP regulating synaptic NMDA and AMPA receptor density and PSD95 turnover.
    7. PSD-93 is identified as a target gene of miR-152-3p.
      Title: MicroRNA-152-3p protects neurons from oxygen-glucose-deprivation/reoxygenation-induced injury through upregulation of Nrf2/ARE antioxidant signaling by targeting PSD-93.
    8. Study describe a novel splice variant of Dlg2 gene termed Dlg2eta and define the differential expression pattern of DLG2 isoforms in IFNbeta-producing plasmacytoid dendritic cells (pDCs). The presence of DLG2eta protein in the CNS of Dlg2 mice might influence the phenotype of these mice and has to be taken into account in the interpretation of results regarding the functional role of DLG2 in neuronal postsynaptic membr...
      Title: Identification of a novel Dlg2 isoform differentially expressed in IFNβ-producing plasmacytoid dendritic cells.
    9. Study found robust hypersocial behavior in the dyadic interaction test in both PSD95(+/-) males and females. Additionally, male PSD95(+/-) mice exhibited higher levels of aggression and territoriality, while female PSD95(+/-) mice showed increased vocalization upon exposure to an anesthetized female mouse. Both male and female PSD95(+/-) mice revealed mild hypoactivity in the open field but no obvious motor deficit.
      Title: Hypersocial behavior and biological redundancy in mice with reduced expression of PSD95 or PSD93.
    10. This study demonstrated that in Chronic social defeat stress leads to changes PSD-93 in hippocampus of young mice.
      Title: Chronic social defeat stress leads to changes of behaviour and memory-associated proteins of young mice.
    Submit: New GeneRIF Correction See all GeneRIFs (23)

    Variation

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    Alleles

    Alleles of this type are documented at Mouse Genome Informatics  (MGI)

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Markers

    Homology

    Gene Ontology Provided by MGI

    Function Evidence Code Pubs
    enables PDZ domain binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables ionotropic glutamate receptor binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables kinase binding ISO
    Inferred from Sequence Orthology
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase binding IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    enables protein phosphatase binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables protein-containing complex binding ISO
    Inferred from Sequence Orthology
    more info
    		  
    enables structural constituent of postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    enables structural constituent of postsynaptic density IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in anterograde axonal protein transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in cell-cell adhesion IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in cellular response to potassium ion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in chemical synaptic transmission IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    acts_upstream_of_or_within chemical synaptic transmission IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in clustering of voltage-gated potassium channels IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in clustering of voltage-gated potassium channels IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in establishment or maintenance of epithelial cell apical/basal polarity IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in maintenance of postsynaptic density structure IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in nervous system development IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in neuronal ion channel clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in neurotransmitter receptor localization to postsynaptic specialization membrane IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in protein localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor clustering IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in receptor clustering ISO
    Inferred from Sequence Orthology
    more info
    		  
    involved_in receptor localization to synapse IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in regulation of postsynaptic membrane neurotransmitter receptor levels IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    involved_in retrograde axonal protein transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within sensory perception of pain IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in axon cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in axon initial segment IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in axon initial segment IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in basolateral plasma membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in cell junction IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in dendrite ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in glutamatergic synapse IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    is_active_in glutamatergic synapse IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    is_active_in glutamatergic synapse ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in juxtaparanode region of axon IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in juxtaparanode region of axon ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    is_active_in neuromuscular junction IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuromuscular junction IEA
    Inferred from Electronic Annotation
    more info
    		  
    is_active_in neuron projection IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    located_in neuronal cell body ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in perikaryon IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in postsynaptic density IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    is_active_in postsynaptic density membrane IBA
    Inferred from Biological aspect of Ancestor
    more info
    		  
    is_active_in postsynaptic density membrane ISO
    Inferred from Sequence Orthology
    more info
    		  
    located_in postsynaptic membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in synaptic vesicle membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of voltage-gated potassium channel complex ISO
    Inferred from Sequence Orthology
    more info
    		  
    part_of voltage-gated potassium channel complex ISS
    Inferred from Sequence or Structural Similarity
    more info
    		  

    General protein information

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    Preferred Names
    disks large homolog 2
    Names
    channel-associated protein of synapse-110
    chapsyn-110
    discs large MAGUK scaffold protein 2 eta
    discs large MAGUK scaffold protein 2 gamma
    discs, large homolog 2
    postsynaptic density protein PSD-93

    NCBI Reference Sequences (RefSeq)

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    RefSeqs maintained independently of Annotated Genomes

    These reference sequences exist independently of genome builds. Explain

    These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

    mRNA and Protein(s)

    1. NM_001243046.1 → NP_001229975.1  disks large homolog 2 isoform 2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (2) differs in the 5' UTR and has multiple differences in the coding region, but maintains the reading frame, compared to variant 1. The encoded isoform (2) has a distinct N-terminus and is shorter, compared to isoform 1.
      Source sequence(s)
      AC141890, AC158144, AK030221
      Consensus CDS
      CCDS57562.1
      UniProtKB/TrEMBL
      D3YWU0
      Related
      ENSMUSP00000095910.3, ENSMUST00000098308.4
      Conserved Domains (4) summary
      smart00072
      Location:301 → 468
      GuKc; Guanylate kinase homologues
      cd00992
      Location:16 → 94
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:290 → 468
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:131 → 204
      SH3; Src Homology 3 domain superfamily

    2. NM_001243047.1 → NP_001229976.1  disks large homolog 2 isoform 3

      See identical proteins and their annotated locations for NP_001229976.1

      Status: VALIDATED

      Description
      Transcript Variant: This variant (3) differs in the 5' UTR and uses a downstream, in-frame start codon, compared to variant 1. The encoded isoform (3) has a shorter N-terminus, compared to isoform 1.
      Source sequence(s)
      AC141890, AC158144, AK039754, CB520190
      UniProtKB/Swiss-Prot
      Q91XM9
      Conserved Domains (2) summary
      pfam00625
      Location:143 → 321
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    3. NM_011807.3 → NP_035937.2  disks large homolog 2 isoform 1

      See identical proteins and their annotated locations for NP_035937.2

      Status: VALIDATED

      Description
      Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform (1).
      Source sequence(s)
      AC109506, AC118621, AC119218, AC121261, AC127299, AC141890, AC158144, AC161490
      Consensus CDS
      CCDS40021.1
      UniProtKB/Swiss-Prot
      F8VQM7, Q8BXK7, Q8BYG5, Q91XM9
      UniProtKB/TrEMBL
      E9Q2L2
      Related
      ENSMUSP00000102814.3, ENSMUST00000107196.10
      Conserved Domains (6) summary
      cd12032
      Location:534 → 607
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      smart00072
      Location:672 → 839
      GuKc; Guanylate kinase homologues
      cd00992
      Location:419 → 497
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:661 → 839
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278 → 345
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 97
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference GRCm39 C57BL/6J

    Genomic

    1. NC_000073.7 Reference GRCm39 C57BL/6J

      Range
      90125399..92098454
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. XM_036153031.1 → XP_036008924.1  disks large homolog 2 isoform X8

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:624 → 697
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:509 → 587
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:783 → 961
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:2 → 62
      L27_1
      pfam10600
      Location:420 → 483
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:157 → 239
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    2. XM_006507776.5 → XP_006507839.1  disks large homolog 2 isoform X7

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:625 → 698
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:510 → 588
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:784 → 962
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:421 → 484
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 240
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    3. XM_006507769.5 → XP_006507832.1  disks large homolog 2 isoform X2

      See identical proteins and their annotated locations for XP_006507832.1

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:676 → 749
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:561 → 639
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:835 → 1013
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:2 → 62
      L27_1
      pfam10600
      Location:420 → 487
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:157 → 239
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    4. XM_006507767.5 → XP_006507830.1  disks large homolog 2 isoform X1

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:677 → 750
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:562 → 640
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:836 → 1014
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:421 → 488
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 240
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    5. XM_006507771.5 → XP_006507834.1  disks large homolog 2 isoform X4

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:677 → 750
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:562 → 640
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:822 → 1000
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:421 → 488
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 240
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    6. XM_036153032.1 → XP_036008925.1  disks large homolog 2 isoform X9

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:625 → 698
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:510 → 588
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:766 → 944
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:421 → 484
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 240
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    7. XM_006507777.5 → XP_006507840.1  disks large homolog 2 isoform X10

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:625 → 698
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:510 → 588
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:752 → 930
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:421 → 484
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 240
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    8. XM_006507770.5 → XP_006507833.1  disks large homolog 2 isoform X3

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:676 → 749
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:561 → 639
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:835 → 1013
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:420 → 487
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 239
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    9. XM_006507772.5 → XP_006507835.1  disks large homolog 2 isoform X5

      UniProtKB/TrEMBL
      A0A338P6J0
      Conserved Domains (6) summary
      cd12032
      Location:677 → 750
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:562 → 640
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:818 → 996
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:421 → 488
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 240
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    10. XM_006507773.5 → XP_006507836.1  disks large homolog 2 isoform X6

      UniProtKB/TrEMBL
      A0A338P6J0
      Related
      ENSMUSP00000155862.3, ENSMUST00000231777.3
      Conserved Domains (6) summary
      cd12032
      Location:677 → 750
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:562 → 640
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:804 → 982
      Guanylate_kin; Guanylate kinase
      pfam09058
      Location:4 → 63
      L27_1
      pfam10600
      Location:421 → 488
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:158 → 240
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    11. XM_006507779.4 → XP_006507842.1  disks large homolog 2 isoform X12

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:555 → 628
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:440 → 518
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:714 → 892
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:299 → 366
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:36 → 118
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    12. XM_036153033.1 → XP_036008926.1  disks large homolog 2 isoform X15

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:554 → 627
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:439 → 517
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:713 → 891
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:298 → 365
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:36 → 117
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    13. XM_036153043.1 → XP_036008936.1  disks large homolog 2 isoform X32

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:482 → 555
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:367 → 445
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:641 → 819
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278 → 341
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 97
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    14. XM_006507784.5 → XP_006507847.1  disks large homolog 2 isoform X20

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:533 → 606
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:418 → 496
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:692 → 870
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:277 → 344
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 96
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    15. XM_006507783.5 → XP_006507846.1  disks large homolog 2 isoform X19

      UniProtKB/TrEMBL
      E9Q2L2
      Related
      ENSMUSP00000073885.4, ENSMUST00000074273.10
      Conserved Domains (5) summary
      cd12032
      Location:534 → 607
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:419 → 497
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:693 → 871
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:278 → 345
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 97
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    16. XM_036153038.1 → XP_036008931.1  disks large homolog 2 isoform X24

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:533 → 606
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:418 → 496
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:674 → 852
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:277 → 344
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 96
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    17. XM_036153041.1 → XP_036008934.1  disks large homolog 2 isoform X28

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:533 → 606
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:418 → 496
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:660 → 838
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:277 → 344
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:14 → 96
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    18. XM_006507781.5 → XP_006507844.1  disks large homolog 2 isoform X14

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:554 → 627
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:439 → 517
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:713 → 891
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:298 → 365
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:34 → 117
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    19. XM_036153035.1 → XP_036008928.1  disks large homolog 2 isoform X18

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:554 → 627
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:439 → 517
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:695 → 873
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:298 → 365
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:34 → 117
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    20. XM_036153036.1 → XP_036008929.1  disks large homolog 2 isoform X21

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:554 → 627
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:439 → 517
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:681 → 859
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:298 → 365
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:34 → 117
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    21. XM_036153040.1 → XP_036008933.1  disks large homolog 2 isoform X27

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:502 → 575
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:387 → 465
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:661 → 839
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:298 → 361
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:34 → 117
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    22. XM_006507782.5 → XP_006507845.1  disks large homolog 2 isoform X16

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:553 → 626
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:438 → 516
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:712 → 890
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:297 → 364
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:34 → 116
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    23. XM_030242541.2 → XP_030098401.1  disks large homolog 2 isoform X22

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:553 → 626
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:438 → 516
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:680 → 858
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:297 → 364
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:34 → 116
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    24. XM_006507786.4 → XP_006507849.1  disks large homolog 2 isoform X30

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:492 → 565
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:377 → 455
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:651 → 829
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:236 → 303
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:25 → 55
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    25. XM_036153045.1 → XP_036008938.1  disks large homolog 2 isoform X34

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:492 → 565
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:377 → 455
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:619 → 797
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:236 → 303
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:24 → 55
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    26. XM_030242543.2 → XP_030098403.1  disks large homolog 2 isoform X36

      UniProtKB/TrEMBL
      D3YUZ8
      Conserved Domains (5) summary
      cd12032
      Location:440 → 513
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:325 → 403
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:599 → 777
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:236 → 299
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:25 → 55
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    27. XM_036153037.1 → XP_036008930.1  disks large homolog 2 isoform X23

      UniProtKB/TrEMBL
      A0A571BEK3
      Conserved Domains (5) summary
      cd12032
      Location:517 → 590
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:676 → 854
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:313 → 376
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 132
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    28. XM_036153039.1 → XP_036008932.1  disks large homolog 2 isoform X26

      UniProtKB/TrEMBL
      A0A571BEK3
      Conserved Domains (5) summary
      cd12032
      Location:517 → 590
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:662 → 840
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:313 → 376
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 132
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    29. XM_036153042.1 → XP_036008935.1  disks large homolog 2 isoform X31

      UniProtKB/TrEMBL
      A0A571BEK3
      Conserved Domains (5) summary
      cd12032
      Location:517 → 590
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:402 → 480
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:644 → 822
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:313 → 376
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 132
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    30. XM_006507778.4 → XP_006507841.1  disks large homolog 2 isoform X11

      UniProtKB/TrEMBL
      A0A571BEK3, A0A571BEZ4
      Related
      ENSMUSP00000158695.2, ENSMUST00000238467.2
      Conserved Domains (5) summary
      cd12032
      Location:569 → 642
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:454 → 532
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:728 → 906
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:313 → 380
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 132
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    31. XM_006507780.4 → XP_006507843.1  disks large homolog 2 isoform X13

      UniProtKB/TrEMBL
      A0A571BEK3
      Conserved Domains (5) summary
      cd12032
      Location:569 → 642
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:454 → 532
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:714 → 892
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:313 → 380
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 132
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    32. XM_036153034.1 → XP_036008927.1  disks large homolog 2 isoform X17

      UniProtKB/TrEMBL
      A0A571BEK3
      Related
      ENSMUSP00000158731.2, ENSMUST00000238619.2
      Conserved Domains (5) summary
      cd12032
      Location:569 → 642
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:454 → 532
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:696 → 874
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:313 → 380
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:45 → 132
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    33. XM_006507785.1 → XP_006507848.1  disks large homolog 2 isoform X25

      UniProtKB/TrEMBL
      E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:507 → 580
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:392 → 470
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:666 → 844
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:251 → 318
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:42 → 70
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    34. XM_030242542.1 → XP_030098402.1  disks large homolog 2 isoform X29

      UniProtKB/TrEMBL
      A0A2L2P590, E9Q2L2
      Conserved Domains (5) summary
      cd12032
      Location:507 → 580
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:392 → 470
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:652 → 830
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:251 → 318
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:42 → 70
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    35. XM_036153044.1 → XP_036008937.1  disks large homolog 2 isoform X33

      UniProtKB/TrEMBL
      D3YUZ8
      Conserved Domains (5) summary
      cd12032
      Location:507 → 580
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:392 → 470
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:634 → 812
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:251 → 318
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:42 → 70
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    36. XM_036153047.1 → XP_036008940.1  disks large homolog 2 isoform X37

      UniProtKB/TrEMBL
      D3YUZ8
      Related
      ENSMUSP00000102811.2, ENSMUST00000107193.8
      Conserved Domains (5) summary
      cd12032
      Location:455 → 528
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:340 → 418
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:582 → 760
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:251 → 314
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:42 → 70
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    37. XM_036153046.1 → XP_036008939.1  disks large homolog 2 isoform X35

      UniProtKB/TrEMBL
      D3YUZ8
      Conserved Domains (5) summary
      cd12032
      Location:455 → 528
      SH3_DLG2; Src Homology 3 domain of Disks Large homolog 2
      cd00992
      Location:340 → 418
      PDZ_signaling; PDZ domain found in a variety of Eumetazoan signaling molecules, often in tandem arrangements. May be responsible for specific protein-protein interactions, as most PDZ domains bind C-terminal polypeptides, and binding to internal (non-C-terminal) ...
      pfam00625
      Location:614 → 792
      Guanylate_kin; Guanylate kinase
      pfam10600
      Location:251 → 314
      PDZ_assoc; PDZ-associated domain of NMDA receptors
      pfam10608
      Location:42 → 70
      MAGUK_N_PEST; Polyubiquitination (PEST) N-terminal domain of MAGUK

    38. XM_006507789.5 → XP_006507852.1  disks large homolog 2 isoform X38

      See identical proteins and their annotated locations for XP_006507852.1

      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    39. XM_036153050.1 → XP_036008943.1  disks large homolog 2 isoform X40

      Conserved Domains (2) summary
      pfam00625
      Location:157 → 335
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    40. XM_006507788.5 → XP_006507851.1  disks large homolog 2 isoform X38

      See identical proteins and their annotated locations for XP_006507851.1

      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    41. XM_036153049.1 → XP_036008942.1  disks large homolog 2 isoform X40

      Conserved Domains (2) summary
      pfam00625
      Location:157 → 335
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    42. XM_006507790.5 → XP_006507853.1  disks large homolog 2 isoform X41

      See identical proteins and their annotated locations for XP_006507853.1

      Conserved Domains (2) summary
      pfam00625
      Location:143 → 321
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    43. XM_006507787.5 → XP_006507850.1  disks large homolog 2 isoform X38

      See identical proteins and their annotated locations for XP_006507850.1

      Conserved Domains (2) summary
      pfam00625
      Location:175 → 353
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    44. XM_036153051.1 → XP_036008944.1  disks large homolog 2 isoform X40

      Conserved Domains (2) summary
      pfam00625
      Location:157 → 335
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily

    45. XM_036153048.1 → XP_036008941.1  disks large homolog 2 isoform X39

      UniProtKB/TrEMBL
      A0A2L2P595
      Conserved Domains (2) summary
      pfam00625
      Location:161 → 339
      Guanylate_kin; Guanylate kinase
      cl17036
      Location:16 → 89
      SH3; Src Homology 3 domain superfamily
    Nucleotide Protein Strain
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q91XM9.2 GenPept UniProtKB/Swiss-Prot:Q91XM9

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