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    AGO6 Argonaute family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817856, updated on 18-Sep-2024

    Summary

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    Official Symbol
    AGO6
    Official Full Name
    Argonaute family protein
    Primary source
    TAIR:AT2G32940
    Locus tag
    AT2G32940
    See related
    Araport:AT2G32940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARGONAUTE 6; T21L14.12; T21L14_12
    Summary
    Encodes a nuclear localized 879-amino-acid protein that contains conserved PAZ and PIWI domains that is important for the accumulation of specific heterochromatin-related siRNAs, and for DNA methylation and transcriptional gene silencing.
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    Genomic context

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    See AGO6 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Sequence:
    Chromosome: 2; NC_003071.7 (13971916..13977521, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene PDI-like 2-3 Neighboring gene zinc finger nuclease 2 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene Phosphotyrosine protein phosphatases superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation. McCue AD, et al. EMBO J, 2015 Jan 2. PMID 25388951, Free PMC Article
    2. AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana. Eun C, et al. PLoS One, 2011. PMID 21998686, Free PMC Article
    3. Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing. Zheng X, et al. EMBO J, 2007 Mar 21. PMID 17332757, Free PMC Article
    4. The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation. Liu W, et al. Nucleic Acids Res, 2022 Dec 9. PMID 36477368, Free PMC Article
    5. The canonical RdDM pathway mediates the control of seed germination timing under salinity. Palomar VM, et al. Plant J, 2021 Feb. PMID 33131171

    See all (9) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation.
      Title: The mechanisms of siRNA selection by plant Argonaute proteins triggering DNA methylation.
    2. The canonical RdDM pathway mediates the control of seed germination timing under salinity.
      Title: The canonical RdDM pathway mediates the control of seed germination timing under salinity.
    3. AGO4 and AGO6 mainly act sequentially in mediating small RNA-directed DNA methylation.
      Title: Specific but interdependent functions for Arabidopsis AGO4 and AGO6 in RNA-directed DNA methylation.
    4. ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation.
      Title: ARGONAUTE 6 bridges transposable element mRNA-derived siRNAs to the establishment of DNA methylation.
    5. the identification of the related AGO6 in a forward genetic screen for mutants defective in RNA-directed DNA methylation and transcriptional gene silencing in shoot and root apical meristems in Arabidopsis thaliana
      Title: AGO6 functions in RNA-mediated transcriptional gene silencing in shoot and root meristems in Arabidopsis thaliana.
    6. AGO6 is important for the accumulation of specific heterochromatin-related siRNAs, and for DNA methylation and transcriptional gene silencing, this function is partly redundant with AGO4. [AGO6]
      Title: Role of Arabidopsis AGO6 in siRNA accumulation, DNA methylation and transcriptional gene silencing.
    Submit: New GeneRIF Correction

    General gene information

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    NM_128854.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables siRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within defense response to virus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within siRNA processing IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Argonaute family protein
    NP_180853.2
    • ARGONAUTE 6 (AGO6); CONTAINS InterPro DOMAIN/s: Domain of unknown function DUF1785 (InterPro:IPR014811), Stem cell self-renewal protein Piwi (InterPro:IPR003165), Polynucleotidyl transferase, ribonuclease H fold (InterPro:IPR012337), Argonaute/Dicer protein, PAZ (InterPro:IPR003100); BEST Arabidopsis thaliana protein match is: Argonaute family protein (TAIR:AT5G21150.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13971916..13977521 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128854.4 → NP_180853.2  Argonaute family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_180853.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O48771
      UniProtKB/TrEMBL
      A0A178VS53, A0A654EZS0
      Conserved Domains (1) summary
      PLN03202
      Location:15 → 878
      PLN03202; protein argonaute; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O48771.2

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