U.S. flag

An official website of the United States government

Format

Send to:

Choose Destination

Links from GEO Profiles

    • Showing Current items.

    LAP1 Cytosol aminopeptidase family protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816954, updated on 18-Sep-2024

    Summary

    Go to the top of the page Help
    Official Symbol
    LAP1
    Official Full Name
    Cytosol aminopeptidase family protein
    Primary source
    TAIR:AT2G24200
    Locus tag
    AT2G24200
    See related
    Araport:AT2G24200
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F27D4.11; F27D4_11; leucyl aminopeptidase 1
    NEW
    Try the new Gene table
    Try the new Transcript table

    Genomic context

    Go to the top of the page Help
    See LAP1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    10
    Sequence:
    Chromosome: 2; NC_003071.7 (10286806..10289685, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Endomembrane protein 70 protein family Neighboring gene cytochrome p450 71b6 Neighboring gene NAD(P)-binding Rossmann-fold superfamily protein Neighboring gene uncharacterized protein Neighboring gene ECA1 gametogenesis related family protein Neighboring gene terpene synthase 10

    Genomic regions, transcripts, and products

    Go to the top of the page Help
    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

    Go to the top of the pageHelp

    Related articles in PubMed

    1. Plant leucine aminopeptidases moonlight as molecular chaperones to alleviate stress-induced damage. Scranton MA, et al. J Biol Chem, 2012 May 25. PMID 22493451, Free PMC Article
    2. Proximity labeling of protein complexes and cell-type-specific organellar proteomes in Arabidopsis enabled by TurboID. Mair A, et al. Elife, 2019 Sep 19. PMID 31535972, Free PMC Article
    3. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
    4. Defining the cytosolic pathway of glutathione degradation in Arabidopsis thaliana: role of the ChaC/GCG family of γ-glutamyl cyclotransferases as glutathione-degrading enzymes and AtLAP1 as the Cys-Gly peptidase. Kumar S, et al. Biochem J, 2015 May 15. PMID 25716890
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (10) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

    Go to the top of the page Help
    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

    Go to the top of the page Help
    NM_001124903.1
    NM_001202658.1
    NM_127981.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables aminopeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables dipeptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables manganese ion binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables metalloaminopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in chloroplast stroma HDA PubMed 
    located_in cytoplasm IEA
    Inferred from Electronic Annotation
    more info
    		  
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

    Go to the top of the page Help
    Preferred Names
    Cytosol aminopeptidase family protein
    NP_001118375.1
    • Cytosol aminopeptidase family protein; FUNCTIONS IN: manganese ion binding, metalloexopeptidase activity, aminopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M17, leucyl aminopeptidase, C-terminal (InterPro:IPR000819), Peptidase M17, leucyl aminopeptidase, N-terminal (InterPro:IPR008283), Peptidase M17, leucyl aminopeptidase (InterPro:IPR011356); BEST Arabidopsis thaliana protein match is: Cytosol aminopeptidase family protein (TAIR:AT4G30920.1); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_001189587.1
    • Cytosol aminopeptidase family protein; FUNCTIONS IN: manganese ion binding, metalloexopeptidase activity, aminopeptidase activity; INVOLVED IN: proteolysis; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M17, leucyl aminopeptidase, C-terminal (InterPro:IPR000819), Peptidase M17, leucyl aminopeptidase, N-terminal (InterPro:IPR008283), Peptidase M17, leucyl aminopeptidase (InterPro:IPR011356); BEST Arabidopsis thaliana protein match is: Cytosol aminopeptidase family protein (TAIR:AT4G30920.1).
    NP_179997.1
    • Cytosol aminopeptidase family protein; FUNCTIONS IN: manganese ion binding, metalloexopeptidase activity, aminopeptidase activity; INVOLVED IN: response to cadmium ion, proteolysis; LOCATED IN: vacuole; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase M17, leucyl aminopeptidase, C-terminal (InterPro:IPR000819), Peptidase M17, leucyl aminopeptidase, N-terminal (InterPro:IPR008283), Peptidase M17, leucyl aminopeptidase (InterPro:IPR011356); BEST Arabidopsis thaliana protein match is: Cytosol aminopeptidase family protein (TAIR:AT4G30920.1); Has 9835 Blast hits to 9833 proteins in 2023 species: Archae - 18; Bacteria - 5432; Metazoa - 659; Fungi - 36; Plants - 122; Viruses - 1; Other Eukaryotes - 3567 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

    Go to the top of the page Help

    NEW Try the new Transcript table

    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      10286806..10289685 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127981.4 → NP_179997.1  Cytosol aminopeptidase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179997.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30184
      UniProtKB/TrEMBL
      A0A178VYU7, A0A5S9X0U3
      Conserved Domains (1) summary
      PRK00913
      Location:20 → 516
      PRK00913; multifunctional aminopeptidase A; Provisional

    2. NM_001202658.1 → NP_001189587.1  Cytosol aminopeptidase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189587.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X0U3, F4INR3
      Conserved Domains (2) summary
      PRK00913
      Location:20 → 480
      PRK00913; multifunctional aminopeptidase A; Provisional
      cd00433
      Location:33 → 478
      Peptidase_M17; Cytosol aminopeptidase family, N-terminal and catalytic domains. Family M17 contains zinc- and manganese-dependent exopeptidases ( EC 3.4.11.1), including leucine aminopeptidase. They catalyze removal of amino acids from the N-terminus of a protein and ...

    3. NM_001124903.1 → NP_001118375.1  Cytosol aminopeptidase family protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118375.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P30184
      UniProtKB/TrEMBL
      A0A178VYU7, A0A5S9X0U3
      Conserved Domains (1) summary
      PRK00913
      Location:20 → 516
      PRK00913; multifunctional aminopeptidase A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P30184.1

    Gene LinkOut

    The following LinkOut resources are supplied by external providers. These providers are responsible for maintaining the links.

    Other Literature Sources
    Molecular Biology Databases
    Research Materials
    Tools