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    Major facilitator superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817764, updated on 18-Sep-2024

    Summary

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    Official Full Name
    Major facilitator superfamily protein
    Primary source
    TAIR:AT2G32040
    Locus tag
    AT2G32040
    See related
    Araport:AT2G32040
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F22D22.21; F22D22_21
    Summary
    The At2g32040 gene product has been demonstrated to mediate folate monoglutamate transport involved in tetrahydrofolate biosynthesis. It also mediates transport of antifolates, such as methotrexate and aminopterin. The gene is expressed in both chloroplast and non-green plastids.
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    Genomic context

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    Location:
    chromosome: 2
    Exon count:
    9
    Sequence:
    Chromosome: 2; NC_003071.7 (13635094..13638081)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene Acyl-CoA N-acyltransferases (NAT) superfamily protein Neighboring gene cell cycle control-like protein (DUF572) Neighboring gene Ribosomal protein L7Ae/L30e/S12e/Gadd45 family protein Neighboring gene Polynucleotidyl transferase, ribonuclease H-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Higher plant plastids and cyanobacteria have folate carriers related to those of trypanosomatids. Klaus SM, et al. J Biol Chem, 2005 Nov 18. PMID 16162503
    2. Identification of transport-critical residues in a folate transporter from the folate-biopterin transporter (FBT) family. Eudes A, et al. J Biol Chem, 2010 Jan 22. PMID 19923217, Free PMC Article
    3. Border control--a membrane-linked interactome of Arabidopsis. Jones AM, et al. Science, 2014 May 16. PMID 24833385
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001336368.1
    NM_128764.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables 5-formyltetrahydrofolate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables folic acid transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables methotrexate transmembrane transporter activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in methotrexate transport IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Major facilitator superfamily protein
    NP_565734.1
    • Major facilitator superfamily protein; FUNCTIONS IN: folic acid transporter activity, 5-formyltetrahydrofolate transporter activity, transporter activity; INVOLVED IN: transport; LOCATED IN: membrane, chloroplast envelope; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Major facilitator superfamily, general substrate transporter (InterPro:IPR016196), Biopterin transport-related protein BT1 (InterPro:IPR004324); BEST Arabidopsis thaliana protein match is: Major facilitator superfamily protein (TAIR:AT5G25050.1); Has 2017 Blast hits to 1915 proteins in 421 species: Archae - 4; Bacteria - 671; Metazoa - 3; Fungi - 33; Plants - 272; Viruses - 0; Other Eukaryotes - 1034 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      13635094..13638081
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_128764.4 → NP_565734.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_565734.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SKZ5
      UniProtKB/TrEMBL
      A0A178VQQ8, A0A5S9X3F7
      Conserved Domains (1) summary
      cd17484
      Location:128 → 527
      MFS_FBT; Folate-biopterin transporter of the Major Facilitator Superfamily of transporters

    2. NM_001336368.1 → NP_001323845.1  Major facilitator superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AYE7
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SKZ5.2

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