HAP13 Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: HAP13
Official Full Name: Clathrin adaptor complexes medium subunit family protein
Primary source: TAIR:AT1G60780
Locus tag: AT1G60780
See related: Araport:AT1G60780
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: adaptor protein-1 mu-adaptin 2; AP1M2; F8A5.29; F8A5_29; HAPLESS 13
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Genomic context

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See HAP13 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 11

Sequence:: Chromosome: 1; NC_003070.9 (22368953..22372223, complement)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis HAPLESS13/AP-1micro is critical for pollen sac formation and tapetal function.
Title: Arabidopsis HAPLESS13/AP-1µ is critical for pollen sac formation and tapetal function.
SUB is mis-targeted in hap13-1. However, unlike that of PIN2, the distribution of PIN1 is independent of HAP13. Genetic interference of exocytic trafficking at the TGN/EE by specifically downregulating HAP13 phenocopied the defects of hap13-1 in SUB targeting and ovule development.
Title: HAPLESS13-Mediated Trafficking of STRUBBELIG Is Critical for Ovule Development in Arabidopsis.
AP-1 complex is required for cell plate-targeted trafficking of KNOLLE in dividing plant cells, and that it has a common role in mediating plant and yeast/animal cytokinesis systems which are fundamentally different. [AP1M2]
Title: The AP-1 μ adaptin is required for KNOLLE localization at the cell plate to mediate cytokinesis in Arabidopsis.
HAPLESS13 protein is essential for protein sorting at the trans-Golgi network/early endosome.
Title: HAPLESS13, the Arabidopsis μ1 adaptin, is essential for protein sorting at the trans-Golgi network/early endosome.
Coimmunoprecipitation revealed that muB2 (At1g60780) is complexed with the large subunit gamma-adaptin of AP-1.
Title: Arabidopsis μ-adaptin subunit AP1M of adaptor protein complex 1 mediates late secretory and vacuolar traffic and is required for growth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_104761.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within clathrin-coated vesicle cargo loading, AP-1-mediated	IPI Inferred from Physical Interaction more info	PubMed
acts_upstream_of_or_within intracellular protein transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within post-Golgi vesicle-mediated transport	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within vacuolar transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of AP-1 adaptor complex	IPI Inferred from Physical Interaction more info	PubMed
located_in nucleus	HDA more info	PubMed
located_in trans-Golgi network	IDA Inferred from Direct Assay more info	PubMed
located_in trans-Golgi network transport vesicle membrane	IMP Inferred from Mutant Phenotype more info	PubMed

General protein information

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Preferred Names: Clathrin adaptor complexes medium subunit family protein

NP_176277.1

HAPLESS 13 (HAP13); INVOLVED IN: intracellular protein transport, transport, vesicle-mediated transport; LOCATED IN: clathrin vesicle coat, clathrin adaptor complex; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Clathrin adaptor, mu subunit, conserved site (InterPro:IPR018240), Clathrin adaptor, mu subunit, C-terminal (InterPro:IPR008968), Clathrin adaptor, mu subunit (InterPro:IPR001392), Longin-like (InterPro:IPR011012); BEST Arabidopsis thaliana protein match is: Clathrin adaptor complexes medium subunit family protein (TAIR:AT1G10730.1); Has 2206 Blast hits to 2139 proteins in 330 species: Archae - 0; Bacteria - 0; Metazoa - 1107; Fungi - 506; Plants - 213; Viruses - 0; Other Eukaryotes - 380 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

22368953..22372223 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_104761.4 → NP_176277.1 Clathrin adaptor complexes medium subunit family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_176277.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O22715

UniProtKB/TrEMBL

A0A178WI53, A0A5S9WN50, A0A654EJU4

Conserved Domains (2) summary

cd09250
Location:156 → 426

AP-1_Mu1_Cterm; C-terminal domain of medium Mu1 subunit in clathrin-associated adaptor protein (AP) complex AP-1

cd14835
Location:6 → 145

AP1_Mu_N; AP-1 complex subunit mu N-terminal domain