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    VPS35A vacuolar protein sorting-associated 35A-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816289, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VPS35A
    Official Full Name
    vacuolar protein sorting-associated 35A-like protein
    Primary source
    TAIR:AT2G17790
    Locus tag
    AT2G17790
    See related
    Araport:AT2G17790
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T17A5.7; T17A5_7; VPS35 homolog A; ZIG suppressor 3; ZIP3
    Summary
    Encodes a protein with similarity to yeast VPS35 which encodes a component of the retromer involved in retrograde endosomal transport. Mutants partially suppress the loss of VTI11 function in Arabidopsis and restores gravitropism in the double mutant.
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    Genomic context

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    See VPS35A in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    21
    Sequence:
    Chromosome: 2; NC_003071.7 (7733563..7739675)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene zinc-binding protein-like protein Neighboring gene cylicin Neighboring gene RAC-like 1 Neighboring gene tRNA-Ile

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis. Nodzynski T, et al. Mol Plant, 2013 Nov. PMID 23770835
    2. Interaction between VPS35 and RABG3f is necessary as a checkpoint to control fusion of late compartments with the vacuole. Rodriguez-Furlan C, et al. Proc Natl Acad Sci U S A, 2019 Oct 15. PMID 31570580, Free PMC Article
    3. Mechanisms governing the endosomal membrane recruitment of the core retromer in Arabidopsis. Zelazny E, et al. J Biol Chem, 2013 Mar 29. PMID 23362252, Free PMC Article
    4. Loss-of-function mutations of retromer large subunit genes suppress the phenotype of an Arabidopsis zig mutant that lacks Qb-SNARE VTI11. Hashiguchi Y, et al. Plant Cell, 2010 Jan. PMID 20086190, Free PMC Article
    5. Arabidopsis VPS35, a retromer component, is required for vacuolar protein sorting and involved in plant growth and leaf senescence. Yamazaki M, et al. Plant Cell Physiol, 2008 Feb. PMID 18222962

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. show that, out of the three VPS35 retromer subunits present in Arabidopsis thaliana genome, the VPS35 homolog A plays a prevailing role in trafficking to the lytic vacuole
      Title: Retromer subunits VPS35A and VPS29 mediate prevacuolar compartment (PVC) function in Arabidopsis.
    2. Arabidopsis Rab7 homolog RABG3f participates in the recruitment of the core retromer to the endosomal membrane by interacting with VPS35
      Title: Mechanisms governing the endosomal membrane recruitment of the core retromer in Arabidopsis.
    3. zip3 is a loss-of-function mutant of VPS35A. Expression of VPS35B or VPS35C cannot complement the function of VPS35A.
      Title: Loss-of-function mutations of retromer large subunit genes suppress the phenotype of an Arabidopsis zig mutant that lacks Qb-SNARE VTI11.
    4. findings suggest that VPS35, mainly VPS35b, is involved in sorting proteins to PSVs in seeds, possibly by recycling VSR from PVCs to the Golgi complex, and is also involved in plant growth and senescence in vegetative organs
      Title: Arabidopsis VPS35, a retromer component, is required for vacuolar protein sorting and involved in plant growth and leaf senescence.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_127333.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within intracellular protein transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in retrograde transport, endosome to Golgi IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in endosome membrane IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    part_of retromer, cargo-selective complex IEA
    Inferred from Electronic Annotation
    more info
    		  

    General protein information

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    Preferred Names
    vacuolar protein sorting-associated 35A-like protein
    NP_179370.2
    • VPS35 homolog A (VPS35A); CONTAINS InterPro DOMAIN/s: Vacuolar protein sorting-associated protein 35 (InterPro:IPR005378); BEST Arabidopsis thaliana protein match is: VPS35 homolog B (TAIR:AT1G75850.1); Has 618 Blast hits to 509 proteins in 212 species: Archae - 0; Bacteria - 0; Metazoa - 194; Fungi - 224; Plants - 73; Viruses - 0; Other Eukaryotes - 127 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      7733563..7739675
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127333.5 → NP_179370.2  vacuolar protein sorting-associated 35A-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179370.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q0WMP3, Q7X659
      UniProtKB/TrEMBL
      A0A178VU13, A0A654ETR1
      Conserved Domains (1) summary
      pfam03635
      Location:12 → 748
      Vps35; Vacuolar protein sorting-associated protein 35
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q7X659.1

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