mediator of RNA polymerase II transcription subunit [Arabidopsis thaliana (thale cress)] - Gene

Summary

Go to the top of the page Help

Official Full Name: mediator of RNA polymerase II transcription subunit
Primary source: TAIR:AT2G22370
Locus tag: AT2G22370
See related: Araport:AT2G22370
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: F14M13.23; F14M13_23; MED18; mediator 18
Summary: Encodes a subunit of the mediator complex that affects flowering time and floral organ formation through FLOWERING LOCUS C (FLC) and AGAMOUS (AG).
NEW: Try the new Gene table
Try the new Transcript table

Genomic context

Go to the top of the page Help

See in Genome Data Viewer

Location:: chromosome: 2

Exon count:: 5

Sequence:: Chromosome: 2; NC_003071.7 (9500784..9502210, complement)

Chromosome 2 - NC_003071.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

Go to the top of the page Help

Go to reference sequence details

Genomic Sequence:: NC_003071.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

Go to the top of the page Help

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Mutation of MEDIATOR 18 and chromate trigger twinning of the primary root meristem in Arabidopsis.
Title: Mutation of MEDIATOR 18 and chromate trigger twinning of the primary root meristem in Arabidopsis.
influences root architecture, represses auxin signaling and is a critical factor for cell viability in root meristems
Title: MEDIATOR18 influences Arabidopsis root architecture, represses auxin signaling and is a critical factor for cell viability in root meristems.
Arabidopsis HOOKLESS1 Regulates Responses to Pathogens and Abscisic Acid through Interaction with MED18 and Acetylation of WRKY33 and ABI5 Chromatin
Title: Arabidopsis HOOKLESS1 Regulates Responses to Pathogens and Abscisic Acid through Interaction with MED18 and Acetylation of WRKY33 and ABI5 Chromatin.
MED18 and MEDIATOR20 form a sub-domain within Mediator that controls the balance of salicylic acid and jasmonate associated defense pathways.
Title: MEDIATOR18 and MEDIATOR20 confer susceptibility to Fusarium oxysporum in Arabidopsis thaliana.
MED18 conveys distinct cues to engender transcription underpinning plant responses.
Title: MED18 interaction with distinct transcription factors regulates multiple plant functions.
Here we show that in Arabidopsis thaliana, MEDIATOR SUBUNIT 18 (MED18) affects flowering time and floral organ formation through FLOWERING LOCUS C (FLC) and AGAMOUS (AG). [MED18]
Title: Mediator subunit18 controls flowering time and floral organ identity in Arabidopsis.

Submit: New GeneRIF Correction

Interactions

Go to the top of the page Help

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

Go to the top of the page Help

Homology

Orthologs from OrthoDB

NM_127802.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed
enables transcription coregulator activity	IMP Inferred from Mutant Phenotype more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within carpel development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within miRNA processing	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within negative regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within petal development	IGI Inferred from Genetic Interaction more info	PubMed
involved_in positive regulation of transcription initiation by RNA polymerase II	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of DNA-templated transcription elongation	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of DNA-templated transcription initiation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of defense response to fungus	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of photoperiodism, flowering	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of salicylic acid mediated signaling pathway	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of termination of DNA-templated transcription	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within regulation of timing of transition from vegetative to reproductive phase	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of vernalization response	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to abscisic acid	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in response to ethylene	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within sepal development	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within specification of floral organ number	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within stamen development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
part_of mediator complex	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

Go to the top of the page Help

Preferred Names: mediator of RNA polymerase II transcription subunit

NP_565534.1

unknown protein; Has 127 Blast hits to 127 proteins in 48 species: Archae - 0; Bacteria - 0; Metazoa - 87; Fungi - 0; Plants - 39; Viruses - 0; Other Eukaryotes - 1 (source: NCBI BLink).