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    BLH1 BEL1-like homeodomain 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818167, updated on 18-Sep-2024

    Summary

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    Official Symbol
    BLH1
    Official Full Name
    BEL1-like homeodomain 1
    Primary source
    TAIR:AT2G35940
    Locus tag
    AT2G35940
    See related
    Araport:AT2G35940
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    BEL1-like homeodomain 1; EDA29; embryo sac development arrest 29; F11F19.15; F11F19_15
    Summary
    Encodes a member of the BEL-like homeodomain protein family. Ecotopic expression in the embryo sac leads to defects in nuclear migration and cellularization and embryo sacs with multiple egg cells. Loss of function alleles have no female gametophyte defects. The ecotopic expression phenotype requires KNAT3 because it can be suppressed by loss of KNAT3 function alleles. Localized to the nucleus but interaction with OFP1 relocates it to the cytoplasm.
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    Genomic context

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    See BLH1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    6
    Sequence:
    Chromosome: 2; NC_003071.7 (15088762..15092415, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene RNA helicase family protein Neighboring gene uncharacterized protein Neighboring gene plant U-box 23 Neighboring gene ncRNA Neighboring gene embryo sac development arrest 12 Neighboring gene NDR1/HIN1-like 12

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Bell-like homeodomain selectively regulates the high-irradiance response of phytochrome A. Staneloni RJ, et al. Proc Natl Acad Sci U S A, 2009 Aug 11. PMID 19666535, Free PMC Article
    2. The endophytic fungus Piriformospora indica stimulates the expression of nitrate reductase and the starch-degrading enzyme glucan-water dikinase in tobacco and Arabidopsis roots through a homeodomain transcription factor that binds to a conserved motif in their promoters. Sherameti I, et al. J Biol Chem, 2005 Jul 15. PMID 15710607
    3. Genome-wide gene expression profiling in Arabidopsis thaliana reveals new targets of abscisic acid and largely impaired gene regulation in the abi1-1 mutant. Hoth S, et al. J Cell Sci, 2002 Dec 15. PMID 12432076
    4. BLH1 and KNAT3 modulate ABA responses during germination and early seedling development in Arabidopsis. Kim D, et al. Plant J, 2013 Sep. PMID 23663178
    5. Cell-fate switch of synergid to egg cell in Arabidopsis eostre mutant embryo sacs arises from misexpression of the BEL1-like homeodomain gene BLH1. Pagnussat GC, et al. Plant Cell, 2007 Nov. PMID 18055603, Free PMC Article

    See all (15) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. BLH1 and KNAT3 together modulate seed germination and early seedling development by directly regulating ABI3 expression.
      Title: BLH1 and KNAT3 modulate ABA responses during germination and early seedling development in Arabidopsis.
    2. BLH1 specifically regulates high-irradiance response and not very-low-fluence response of phytochrome A.
      Title: Bell-like homeodomain selectively regulates the high-irradiance response of phytochrome A.
    3. The eostre phenotype is caused by misexpression of the homeodomain gene BEL1-like homeodomain 1 (BLH1) in the embryo sac.
      Title: Cell-fate switch of synergid to egg cell in Arabidopsis eostre mutant embryo sacs arises from misexpression of the BEL1-like homeodomain gene BLH1.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036413.3
    NM_129153.3
    NM_179925.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein heterodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein homodimerization activity IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within polar nucleus fusion IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to abscisic acid IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to continuous far red light stimulus by the high-irradiance response system IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to symbiotic fungus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    BEL1-like homeodomain 1
    NP_001031490.1
    • BEL1-like homeodomain 1 (BLH1); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 6 (TAIR:AT4G34610.2); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_181138.1
    • BEL1-like homeodomain 1 (BLH1); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 6 (TAIR:AT4G34610.2); Has 71711 Blast hits to 13510 proteins in 414 species: Archae - 28; Bacteria - 75; Metazoa - 3080; Fungi - 2154; Plants - 2539; Viruses - 2; Other Eukaryotes - 63833 (source: NCBI BLink).
    NP_850256.1
    • BEL1-like homeodomain 1 (BLH1); CONTAINS InterPro DOMAIN/s: Homeobox (InterPro:IPR001356), Homeodomain-like (InterPro:IPR009057), POX (InterPro:IPR006563), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: BEL1-like homeodomain 6 (TAIR:AT4G34610.2); Has 71711 Blast hits to 13510 proteins in 414 species: Archae - 28; Bacteria - 75; Metazoa - 3080; Fungi - 2154; Plants - 2539; Viruses - 2; Other Eukaryotes - 63833 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      15088762..15092415 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129153.3 → NP_181138.1  BEL1-like homeodomain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181138.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42302, Q94KL4, Q9SJ56
      UniProtKB/TrEMBL
      A0A178VQI8, A0A654F4I7
      Conserved Domains (2) summary
      pfam05920
      Location:403 → 442
      Homeobox_KN; Homeobox KN domain
      pfam07526
      Location:190 → 332
      POX; Associated with HOX

    2. NM_179925.3 → NP_850256.1  BEL1-like homeodomain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850256.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42302, Q94KL4, Q9SJ56
      UniProtKB/TrEMBL
      A0A178VQI8, A0A654F4I7
      Conserved Domains (2) summary
      pfam05920
      Location:403 → 442
      Homeobox_KN; Homeobox KN domain
      pfam07526
      Location:190 → 332
      POX; Associated with HOX

    3. NM_001036413.3 → NP_001031490.1  BEL1-like homeodomain 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031490.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q42302, Q94KL4, Q9SJ56
      UniProtKB/TrEMBL
      A0A178VQI8, A0A654F4I7
      Conserved Domains (2) summary
      pfam05920
      Location:403 → 442
      Homeobox_KN; Homeobox KN domain
      pfam07526
      Location:190 → 332
      POX; Associated with HOX
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SJ56.1

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