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    FER4 ferritin 4 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 818622, updated on 18-Sep-2024

    Summary

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    Official Symbol
    FER4
    Official Full Name
    ferritin 4
    Primary source
    TAIR:AT2G40300
    Locus tag
    AT2G40300
    See related
    Araport:AT2G40300
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATFER4; ferritin 4; T7M7.6
    Summary
    Encodes FERRITIN 4, AtFER4. Ferritins are a class of 24-mer multi-meric proteins found in all kingdoms of life. Function as the main iron store in mammals. Evidence suggests that Arabidopsis ferritins are essential to protect cells against oxidative damage, but they do not constitute the major iron pool. Localize to mitochondria. Knock out mutants are not sensitive to abiotic stress.
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    Genomic context

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    See FER4 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    8
    Sequence:
    Chromosome: 2; NC_003071.7 (16831109..16833294, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Protein kinase family protein Neighboring gene ncRNA Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene Eukaryotic translation initiation factor 2 subunit 1 Neighboring gene Pectin lyase-like superfamily protein Neighboring gene autophagy-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Knocking out of the mitochondrial AtFer4 ferritin does not alter response of Arabidopsis plants to abiotic stresses. Tarantino D, et al. J Plant Physiol, 2010 Apr 15. PMID 19959254
    2. Analysis of Arabidopsis thaliana atfer4-1, atfh and atfer4-1/atfh mutants uncovers frataxin and ferritin contributions to leaf ionome homeostasis. Murgia I, et al. Plant Physiol Biochem, 2015 Sep. PMID 26042547
    3. FERONIA regulates auxin-mediated lateral root development and primary root gravitropism. Dong Q, et al. FEBS Lett, 2019 Jan. PMID 30417333
    4. Iron- and ferritin-dependent reactive oxygen species distribution: impact on Arabidopsis root system architecture. Reyt G, et al. Mol Plant, 2015 Mar. PMID 25624148
    5. Ferritins control interaction between iron homeostasis and oxidative stress in Arabidopsis. Ravet K, et al. Plant J, 2009 Feb. PMID 18826427

    See all (13) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Results demonstrate that the primary root of the fer-4 mutant displays increased lateral root branching and a delayed gravitropic response, which are associated with polar auxin transport.
      Title: FERONIA regulates auxin-mediated lateral root development and primary root gravitropism.
    2. Analysis of Arabidopsis thaliana atfer4-1, atfh and atfer4-1/atfh mutants uncovers frataxin and ferritin contributions to leaf ionome homeostasis.
      Title: Analysis of Arabidopsis thaliana atfer4-1, atfh and atfer4-1/atfh mutants uncovers frataxin and ferritin contributions to leaf ionome homeostasis.
    3. Fe mediated decrease of lateral root length and density is enhanced in fer1-3-4 triple mutant plants.
      Title: Iron- and ferritin-dependent reactive oxygen species distribution: impact on Arabidopsis root system architecture.
    4. Study conclude that the ATFER4 ferritin role in counteracting the environmental or developmental oxidative conditions in Arabidopsis plants is ancillary to that of the other isoforms, regardless of its mitochondrial localization.
      Title: Knocking out of the mitochondrial AtFer4 ferritin does not alter response of Arabidopsis plants to abiotic stresses.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_129588.5

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ferric iron binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ferroxidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within iron ion transport IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within multicellular organismal-level iron ion homeostasis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within photosynthesis IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within response to iron ion IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to reactive oxygen species IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    ferritin 4
    NP_181559.1
    • ferritin 4 (FER4); FUNCTIONS IN: oxidoreductase activity, ferric iron binding, binding, transition metal ion binding; INVOLVED IN: in 8 processes; LOCATED IN: mitochondrion, chloroplast stroma, chloroplast, chloroplast envelope; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: Ferritin, N-terminal (InterPro:IPR001519), Ferritin-related (InterPro:IPR012347), Ferritin-like (InterPro:IPR009040), Ferritin, conserved site (InterPro:IPR014034), Ferritin/ribonucleotide reductase-like (InterPro:IPR009078), Ferritin/Dps protein (InterPro:IPR008331); BEST Arabidopsis thaliana protein match is: ferritin 3 (TAIR:AT3G56090.1); Has 4634 Blast hits to 4632 proteins in 1342 species: Archae - 173; Bacteria - 2136; Metazoa - 1697; Fungi - 13; Plants - 350; Viruses - 0; Other Eukaryotes - 265 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      16831109..16833294 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_129588.5 → NP_181559.1  ferritin 4 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_181559.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q8WHW5, Q9S756
      UniProtKB/TrEMBL
      A0A5S9X5R6, A0A654F5U8
      Conserved Domains (1) summary
      cd01056
      Location:94 → 254
      Euk_Ferritin; eukaryotic ferritins
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9S756.1

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