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    VLN1 villin-like 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 817539, updated on 18-Sep-2024

    Summary

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    Official Symbol
    VLN1
    Official Full Name
    villin-like 1
    Primary source
    TAIR:AT2G29890
    Locus tag
    AT2G29890
    See related
    Araport:AT2G29890
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATVLN1; F6K5.2; F6K5_2; villin 1; villin-like 1
    Summary
    Encodes a ubiquitously expressed villin-like protein, whose mRNA may be alternatively processed. Villin belongs to a superfamily of actin binding proteins called the villin/gelsolin family. Animal villins are involved in actin binding. VLN1 protein co-localizes with actin filaments in several assays. VLN1 binds and bundles F-actin in a calcium-independent manner. It does not nucleate, cap or sever actin filaments and it stabilizes actin filaments, protecting them from ADF-mediated depolymerization.
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    Genomic context

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    See VLN1 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    23
    Sequence:
    Chromosome: 2; NC_003071.7 (12744116..12749596)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene Aquaporin-like superfamily protein Neighboring gene Myb/SANT-like DNA-binding domain protein Neighboring gene Presenilin-2 Neighboring gene F-box/RNI-like superfamily protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Villin-like actin-binding proteins are expressed ubiquitously in Arabidopsis. Klahre U, et al. Plant Physiol, 2000 Jan. PMID 10631247, Free PMC Article
    2. Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover. Khurana P, et al. Plant Cell, 2010 Aug. PMID 20807878, Free PMC Article
    3. Arabidopsis VILLIN1 generates actin filament cables that are resistant to depolymerization. Huang S, et al. Plant Cell, 2005 Feb. PMID 15659626, Free PMC Article
    4. Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Lin X, et al. Nature, 1999 Dec 16. PMID 10617197

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. VLN1 does not protect individual actin filaments from severing by VLN3.
      Title: Arabidopsis VILLIN1 and VILLIN3 have overlapping and distinct activities in actin bundle formation and turnover.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036367.2
    NM_001202706.1
    NM_001336228.1
    NM_128543.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables actin binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables actin filament binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    NOT involved_in actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within actin filament organization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in actin filament severing IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in actin nucleation IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    NOT involved_in barbed-end actin filament capping IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within negative regulation of actin filament depolymerization IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in actin cytoskeleton IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    villin-like 1
    NP_001031444.2
    • villin-like 1 (VLN1); CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 4 (TAIR:AT4G30160.1); Has 3163 Blast hits to 1761 proteins in 187 species: Archae - 0; Bacteria - 6; Metazoa - 2500; Fungi - 105; Plants - 222; Viruses - 0; Other Eukaryotes - 330 (source: NCBI BLink).
    NP_001189635.1
    • villin-like 1 (VLN1); CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 4 (TAIR:AT4G30160.1).
    NP_029567.1
    • villin-like 1 (VLN1); CONTAINS InterPro DOMAIN/s: Gelsolin (InterPro:IPR007122), Villin headpiece (InterPro:IPR003128), Gelsolin domain (InterPro:IPR007123); BEST Arabidopsis thaliana protein match is: villin 4 (TAIR:AT4G30160.1); Has 3095 Blast hits to 1746 proteins in 186 species: Archae - 0; Bacteria - 6; Metazoa - 2441; Fungi - 102; Plants - 219; Viruses - 0; Other Eukaryotes - 327 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      12744116..12749596
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001336227.1 → NP_001324174.1  villin-like 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AZB7, A0A5S9X2Q0

    2. NM_128543.4 → NP_029567.1  villin-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_029567.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81643, O82367, Q9SIK8
      UniProtKB/TrEMBL
      A0A5S9X2Q0
      Conserved Domains (7) summary
      smart00153
      Location:874 → 909
      VHP; Villin headpiece domain
      cd11288
      Location:514 → 605
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:140 → 231
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 123
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:618 → 715
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:245 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:383 → 483
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    3. NM_001202706.1 → NP_001189635.1  villin-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001189635.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X2Q0, F4ILN8
      Conserved Domains (7) summary
      smart00153
      Location:898 → 933
      VHP; Villin headpiece domain
      cd11288
      Location:514 → 605
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:140 → 231
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 123
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:618 → 717
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:245 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:383 → 483
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    4. NM_001036367.2 → NP_001031444.2  villin-like 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031444.2

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X2Q0, Q2V445
      Conserved Domains (7) summary
      smart00153
      Location:876 → 911
      VHP; Villin headpiece domain
      cd11288
      Location:514 → 605
      gelsolin_S5_like; Gelsolin sub-domain 5-like domain found in gelsolin, severin, villin, and related proteins
      cd11289
      Location:140 → 231
      gelsolin_S2_like; Gelsolin sub-domain 2-like domain found in gelsolin, severin, villin, and related proteins
      cd11290
      Location:12 → 123
      gelsolin_S1_like; Gelsolin sub-domain 1-like domain found in gelsolin, severin, villin, and related proteins
      cd11291
      Location:618 → 717
      gelsolin_S6_like; Gelsolin sub-domain 6-like domain found in gelsolin, severin, villin, and related proteins
      cd11292
      Location:245 → 344
      gelsolin_S3_like; Gelsolin sub-domain 3-like domain found in gelsolin, severin, villin, and related proteins
      cd11293
      Location:383 → 483
      gelsolin_S4_like; Gelsolin sub-domain 4-like domain found in gelsolin, severin, villin, and related proteins

    5. NM_001336228.1 → NP_001324173.1  villin-like 1 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O81643, O82367, Q9SIK8
      UniProtKB/TrEMBL
      A0A5S9X2Q0
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O81643.2

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