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    MIPS2 myo-inositol-1-phosphate synthase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 816757, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MIPS2
    Official Full Name
    myo-inositol-1-phosphate synthase 2
    Primary source
    TAIR:AT2G22240
    Locus tag
    AT2G22240
    See related
    Araport:AT2G22240
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ATIPS2; ATMIPS1; ATMIPS2; INOSITOL 3-PHOSPHATE SYNTHASE 2; MIPS1; myo-inositol-1-phosphate synthase 1; myo-inositol-1-phosphate synthase 2; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 1; MYO-INOSITOL-1-PHOSTPATE SYNTHASE 2
    Summary
    ** Referred to as MIPS1 in Mitsuhashi et al 2008. Myo-inositol-1-phosphate synthase isoform 2. Expressed in leaf, root and silique. Immunolocalization experiments with an antibody recognizing MIPS1, MIPS2, and MIPS3 showed endosperm localization.
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    Genomic context

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    See MIPS2 in Genome Data Viewer
    Location:
    chromosome: 2
    Exon count:
    7
    Sequence:
    Chromosome: 2; NC_003071.7 (9451605..9454300, complement)

    Chromosome 2 - NC_003071.7Genomic Context describing neighboring genes Neighboring gene pseudo Neighboring gene tRNA-Ile Neighboring gene Thioesterase superfamily protein Neighboring gene uncharacterized protein Neighboring gene aspartate aminotransferase Neighboring gene oxidoreductase, 2OG-Fe(II) oxygenase family protein Neighboring gene hematological/neurological-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003071.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Influence of cytokinins on the expression of phosphate starvation responsive genes in Arabidopsis. Martín AC, et al. Plant J, 2000 Dec. PMID 11123795
    2. Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis. Fleet CM, et al. Plant Mol Biol, 2018 Jun. PMID 29777485
    3. The Arabidopsis thaliana Myo-inositol 1-phosphate synthase1 gene is required for Myo-inositol synthesis and suppression of cell death. Donahue JL, et al. Plant Cell, 2010 Mar. PMID 20215587, Free PMC Article
    4. A role for inositol hexakisphosphate in the maintenance of basal resistance to plant pathogens. Murphy AM, et al. Plant J, 2008 Nov. PMID 18643983
    5. D-myo-inositol-3-phosphate affects phosphatidylinositol-mediated endomembrane function in Arabidopsis and is essential for auxin-regulated embryogenesis. Luo Y, et al. Plant Cell, 2011 Apr. PMID 21505066, Free PMC Article

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. works with MIPS1 AND MIPS3 to impact the overall synthesis of myo-inositol and overall inositol homeostasis
      Title: Co-suppression of AtMIPS demonstrates cooperation of MIPS1, MIPS2 and MIPS3 in maintaining myo-inositol synthesis.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001335785.1
    NM_127790.4
    NM_201780.2

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables inositol-3-phosphate synthase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables inositol-3-phosphate synthase activity IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within cellular response to phosphate starvation TAS
    Traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to bacterium IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to fungus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within defense response to virus IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in inositol biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within myo-inositol hexakisphosphate biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in phospholipid biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within response to auxin TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    myo-inositol-1-phosphate synthase 2
    NP_179812.1
    • myo-inositol-1-phosphate synthase 2 (MIPS2); CONTAINS InterPro DOMAIN/s: Myo-inositol-1-phosphate synthase (InterPro:IPR002587), Myo-inositol-1-phosphate synthase, GAPDH-like (InterPro:IPR013021), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: myo-inositol-1-phosphate synthase 1 (TAIR:AT4G39800.1); Has 1859 Blast hits to 1855 proteins in 512 species: Archae - 101; Bacteria - 453; Metazoa - 126; Fungi - 158; Plants - 764; Viruses - 0; Other Eukaryotes - 257 (source: NCBI BLink).
    NP_973509.1
    • myo-inositol-1-phosphate synthase 2 (MIPS2); CONTAINS InterPro DOMAIN/s: Myo-inositol-1-phosphate synthase (InterPro:IPR002587), Myo-inositol-1-phosphate synthase, GAPDH-like (InterPro:IPR013021), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: myo-inositol-1-phosphate synthase 1 (TAIR:AT4G39800.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003071.7 Reference assembly

      Range
      9451605..9454300 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_127790.4 → NP_179812.1  myo-inositol-1-phosphate synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_179812.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q38862, Q9SIE2
      UniProtKB/TrEMBL
      A0A178VS65, A0A5S9X0D0, A0A654EV50
      Conserved Domains (1) summary
      PLN02438
      Location:1 → 510
      PLN02438; inositol-3-phosphate synthase

    2. NM_001335785.1 → NP_001324779.1  myo-inositol-1-phosphate synthase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178VS65, A0A1P8B151

    3. NM_201780.2 → NP_973509.1  myo-inositol-1-phosphate synthase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_973509.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      F4IIN3
      Conserved Domains (1) summary
      cl00554
      Location:1 → 380
      NAD_binding_5; Myo-inositol-1-phosphate synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38862.2

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