OTS2 Cysteine proteinases superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: OTS2
Official Full Name: Cysteine proteinases superfamily protein
Primary source: TAIR:AT1G10570
Locus tag: AT1G10570
See related: Araport:AT1G10570
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: OVERLY TOLERANT TO SALT 2; T10O24.20; T10O24_20; UB-LIKE PROTEASE 1C; ULP1C
Summary: Encodes a deSUMOylating enzyme. In vitro it has both peptidase activity and isopeptidase activity: it can cleave the C-terminal residues from SUMO to activate it for attachment to a target protein and it can also act on the isopeptide bond between SUMO and another protein. sYFP:OTS2 protein accumulates in nuclei in a punctate pattern. Double mutant analysis with ULP1D/OTS1 indicates that these genes are involved in salt stress responses and flowering time regulation.
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Genomic context

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See OTS2 in Genome Data Viewer

Location:: chromosome: 1

Exon count:: 14

Sequence:: Chromosome: 1; NC_003070.9 (3487386..3491277)

Chromosome 1 - NC_003070.9 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003070.9

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

The OTS genes are proposed to enable synchronization of stamen development by facilitating DELLA degradation at a specific developmental stage.
Title: SUMO proteases OTS1 and 2 control filament elongation through a DELLA-dependent mechanism.
OTS1 and -2 act in a feedback loop in salicylic acid (SA) signalling and that de novo OTS1/2 synthesis works antagonistically to SA-promoted degradation, adjusting the abundance of OTS1/2 to moderate SA signalling.
Title: Stability of small ubiquitin-like modifier (SUMO) proteases OVERLY TOLERANT TO SALT1 and -2 modulates salicylic acid signalling and SUMO1/2 conjugation in Arabidopsis thaliana.
OTS1 and OTS2 are SUMO proteases which are localized to the nucleus and regulate salt stress responses in Arabidopsis. [OTS2]
Title: Small ubiquitin-like modifier proteases OVERLY TOLERANT TO SALT1 and -2 regulate salt stress responses in Arabidopsis.

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General gene information

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NM_001331913.1

Supported by ESTs:

NM_100932.4

Supported by ESTs:

NM_202073.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables SUMO-specific endopeptidase activity	IDA Inferred from Direct Assay more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
involved_in protein desumoylation	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within response to salt stress	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within vegetative to reproductive phase transition of meristem	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Cysteine proteinases superfamily protein

NP_172527.2

OVERLY TOLERANT TO SALT 2 (OTS2); CONTAINS InterPro DOMAIN/s: Peptidase C48, SUMO/Sentrin/Ubl1 (InterPro:IPR003653); BEST Arabidopsis thaliana protein match is: UB-like protease 1D (TAIR:AT1G60220.1); Has 1265 Blast hits to 1250 proteins in 204 species: Archae - 0; Bacteria - 0; Metazoa - 616; Fungi - 251; Plants - 239; Viruses - 3; Other Eukaryotes - 156 (source: NCBI BLink).

NP_973802.1

OVERLY TOLERANT TO SALT 2 (OTS2); CONTAINS InterPro DOMAIN/s: Peptidase C48, SUMO/Sentrin/Ubl1 (InterPro:IPR003653); BEST Arabidopsis thaliana protein match is: UB-like protease 1D (TAIR:AT1G60220.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003070.9 Reference assembly

Range

3487386..3491277

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202073.4 → NP_973802.1 Cysteine proteinases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_973802.1

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W2X8, A0A5S9TNT4, A0A654EJB6

Conserved Domains (1) summary

pfam02902
Location:344 → 545

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain
NM_001331913.1 → NP_001322371.1 Cysteine proteinases superfamily protein [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/TrEMBL

A0A178W346, A0A1P8ATS5, A0A384LH87
NM_100932.4 → NP_172527.2 Cysteine proteinases superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_172527.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3EDF1, Q8RWN0, Q9XIJ4

UniProtKB/TrEMBL

A0A5S9TNT4, A0A654EJB6

Conserved Domains (1) summary

pfam02902
Location:345 → 545

Peptidase_C48; Ulp1 protease family, C-terminal catalytic domain