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    Pol{lambda} DNA polymerase lambda (POLL) [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 837592, updated on 18-Sep-2024

    Summary

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    Official Symbol
    Pol{lambda}
    Official Full Name
    DNA polymerase lambda (POLL)
    Primary source
    TAIR:AT1G10520
    Locus tag
    AT1G10520
    See related
    Araport:AT1G10520
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtPol{lambda}; DNA polymerase {lambda}; T10O24.13; T10O24_13
    Summary
    Encodes a homolog of the mammalian DNA polymerase lambda that is involved in the repair of UV-B induced DNA damage.
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    Genomic context

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    See Pol{lambda} in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (3465926..3469455)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene GNAT acetyltransferase (DUF699) Neighboring gene chloroplast-localized ISCA-like protein Neighboring gene RNI-like superfamily protein Neighboring gene ncRNA Neighboring gene Serine/Threonine-kinase Neighboring gene D-ribose-binding periplasmic protein Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The enzymatic properties of Arabidopsis thaliana DNA polymerase λ suggest a role in base excision repair. Morales-Ruiz T, et al. Plant Mol Biol, 2024 Jan 13. PMID 38217735, Free PMC Article
    2. Functional analysis of light-regulated promoter region of AtPolλ gene. Roy S, et al. Planta, 2012 Feb. PMID 21947619
    3. Understanding the Physical and Molecular Basis of Stability of Arabidopsis DNA Pol λ under UV-B and High NaCl Stress. Roy S, et al. PLoS One, 2015. PMID 26230318, Free PMC Article
    4. Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2. Amoroso A, et al. Plant Cell, 2011 Feb. PMID 21325140, Free PMC Article
    5. AtPolλ, a homolog of mammalian DNA polymerase λ in Arabidopsis thaliana, is involved in the repair of UV-B induced DNA damage through the dark repair pathway. Roy S, et al. Plant Cell Physiol, 2011 Feb. PMID 21227935

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The enzymatic properties of Arabidopsis thaliana DNA polymerase lambda suggest a role in base excision repair.
      Title: The enzymatic properties of Arabidopsis thaliana DNA polymerase λ suggest a role in base excision repair.
    2. A direct involvement of T1G10520 in the repair of the DNA double strand breaks in a plant genome.
      Title: Involvement of AtPolλ in the repair of high salt- and DNA cross-linking agent-induced double strand breaks in Arabidopsis.
    3. White light positively regulates AtPollambda expression.
      Title: Functional analysis of light-regulated promoter region of AtPolλ gene.
    4. DNA Pol lambda recognizes 8-Oxo-G on a template as a normal guanine and preferentially incorporates dCTP over dATP opposite this lesion.
      Title: Oxidative DNA damage bypass in Arabidopsis thaliana requires DNA polymerase λ and proliferating cell nuclear antigen 2.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100926.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA polymerase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables DNA-directed DNA polymerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in base-excision repair, gap-filling IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within double-strand break repair via nonhomologous end joining IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within nucleotide-excision repair IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within response to UV-B IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    DNA polymerase lambda (POLL)
    NP_172522.2
    • DNA polymerase lambda (POLL); FUNCTIONS IN: DNA binding, DNA-directed DNA polymerase activity, catalytic activity, nucleotidyltransferase activity; INVOLVED IN: DNA repair, DNA replication; LOCATED IN: intracellular; EXPRESSED IN: cultured cell; CONTAINS InterPro DOMAIN/s: Nucleotidyl transferase domain (InterPro:IPR002934), DNA-directed DNA polymerase, family X, beta-like (InterPro:IPR002008), DNA-directed DNA polymerase, family X, beta-like, N-terminal (InterPro:IPR010996), DNA polymerase lambda, fingers domain (InterPro:IPR018944), DNA polymerase family X, binding site (InterPro:IPR019843), DNA-directed DNA polymerase X (InterPro:IPR002054), BRCT (InterPro:IPR001357), DNA polymerase X (InterPro:IPR022312); Has 1887 Blast hits to 1879 proteins in 557 species: Archae - 50; Bacteria - 688; Metazoa - 533; Fungi - 209; Plants - 50; Viruses - 7; Other Eukaryotes - 350 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      3465926..3469455
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001331911.1 → NP_001320966.1  DNA polymerase lambda (POLL) [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W5U8, A0A1P8APE6

    2. NM_100926.3 → NP_172522.2  DNA polymerase lambda (POLL) [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_172522.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9FNY4, Q9XIK1
      UniProtKB/TrEMBL
      A0A178W586, A0A5S9TP53, A0A654E9R3
      Conserved Domains (2) summary
      cd00141
      Location:202 → 527
      NT_POLXc; Nucleotidyltransferase (NT) domain of family X DNA Polymerases
      cl00038
      Location:21 → 63
      BRCT; C-terminal domain of the breast cancer suppressor protein (BRCA1) and related domains
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9FNY4.1

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