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    KNAT6 homeobox protein knotted-1-like 6 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838946, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KNAT6
    Official Full Name
    homeobox protein knotted-1-like 6
    Primary source
    TAIR:AT1G23380
    Locus tag
    AT1G23380
    See related
    Araport:AT1G23380
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F26F24.32; F26F24_32; KNAT6L; KNAT6S; KNOTTED1-like homeobox gene 6
    Summary
    homeodomain transcription factor KNAT6, belonging to class I of KN transcription factor family (which also includes KNAT1 and KNAT2). Expression is increased in as and bop1 leaf mutants.
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    Genomic context

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    See KNAT6 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    5
    Sequence:
    Chromosome: 1; NC_003070.9 (8297241..8302651, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Plant invertase/pectin methylesterase inhibitor superfamily protein Neighboring gene S-adenosyl-L-methionine-dependent methyltransferases superfamily protein Neighboring gene ncRNA Neighboring gene ncRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. KNAT6: an Arabidopsis homeobox gene involved in meristem activity and organ separation. Belles-Boix E, et al. Plant Cell, 2006 Aug. PMID 16798887, Free PMC Article
    2. Arabidopsis BREVIPEDICELLUS interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA to regulate KNAT2 and KNAT6 expression in control of inflorescence architecture. Zhao M, et al. PLoS Genet, 2015 Mar. PMID 25822547, Free PMC Article
    3. BLADE-ON-PETIOLE1 and 2 regulate Arabidopsis inflorescence architecture in conjunction with homeobox genes KNAT6 and ATH1. Khan M, et al. Plant Signal Behav, 2012 Jul. PMID 22751300, Free PMC Article
    4. ATH1 and KNAT2 proteins act together in regulation of plant inflorescence architecture. Li Y, et al. J Exp Bot, 2012 Feb. PMID 22140242, Free PMC Article
    5. Interaction of KNAT6 and KNAT2 with BREVIPEDICELLUS and PENNYWISE in Arabidopsis inflorescences. Ragni L, et al. Plant Cell, 2008 Apr. PMID 18390591, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. our results indicate that BP interacts with the chromatin remodeling factor BRM to regulate the expression of KNAT2 and KNAT6 in control of inflorescence architecture.
      Title: Arabidopsis BREVIPEDICELLUS interacts with the SWI2/SNF2 chromatin remodeling ATPase BRAHMA to regulate KNAT2 and KNAT6 expression in control of inflorescence architecture.
    2. BOP1/2 gain-of-function in stems promotes expression of the boundary gene KNOTTED1-LIKE FROM ARABIDOPSIS THALIANA6 (KNAT6) and ARABIDOPSIS THALIANA HOMEOBOX GENE1 (ATH1).
      Title: BLADE-ON-PETIOLE1 and 2 regulate Arabidopsis inflorescence architecture in conjunction with homeobox genes KNAT6 and ATH1.
    3. The data indicate that the ATH1-KNAT2 complex acts redundantly with KNAT6, both of which are negatively regulated by BP during pedicel development.
      Title: ATH1 and KNAT2 proteins act together in regulation of plant inflorescence architecture.
    4. Results suggested that the late-flowering phenotype of the as1-1 and as2-1 mutants might have been caused by the ectopic expression of KNAT126 triple mutation.
      Title: Genetic networks regulated by ASYMMETRIC LEAVES1 (AS1) and AS2 in leaf development in Arabidopsis thaliana: KNOX genes control five morphological events.
    5. KNAT6 and KNAT2 expression is restricted by BP and PNY to promote correct inflorescence development
      Title: Interaction of KNAT6 and KNAT2 with BREVIPEDICELLUS and PENNYWISE in Arabidopsis inflorescences.
    6. KNAT6 contributes to SAM maintenance and boundary establishment in the embryo via the SHOOT MERISTEMLESS(STM)/CUP-SHAPED COTYLEDON (CUC) pathway.
      Title: KNAT6: an Arabidopsis homeobox gene involved in meristem activity and organ separation.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_102187.4
    NM_180620.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity, RNA polymerase II-specific IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within meristem maintenance IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    homeobox protein knotted-1-like 6
    NP_173752.3
    • KNOTTED1-like homeobox gene 6 (KNAT6); FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: meristem maintenance; LOCATED IN: nucleus; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: KNOX2 (InterPro:IPR005541), ELK (InterPro:IPR005539), Homeobox (InterPro:IPR001356), Homeobox, conserved site (InterPro:IPR017970), KNOX1 (InterPro:IPR005540), Homeodomain-like (InterPro:IPR009057), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: KNOTTED-like from Arabidopsis thaliana 2 (TAIR:AT1G70510.1); Has 6018 Blast hits to 6018 proteins in 364 species: Archae - 0; Bacteria - 0; Metazoa - 1717; Fungi - 270; Plants - 3877; Viruses - 0; Other Eukaryotes - 154 (source: NCBI BLink).
    NP_850951.2
    • KNOTTED1-like homeobox gene 6 (KNAT6); FUNCTIONS IN: DNA binding, transcription activator activity, sequence-specific DNA binding transcription factor activity; INVOLVED IN: meristem maintenance; LOCATED IN: nucleus; EXPRESSED IN: 10 plant structures; EXPRESSED DURING: 4 anthesis, F mature embryo stage, petal differentiation and expansion stage, E expanded cotyledon stage, D bilateral stage; CONTAINS InterPro DOMAIN/s: KNOX2 (InterPro:IPR005541), ELK (InterPro:IPR005539), Homeobox (InterPro:IPR001356), KNOX1 (InterPro:IPR005540), Homeobox, conserved site (InterPro:IPR017970), Homeodomain-like (InterPro:IPR009057), Homeodomain-related (InterPro:IPR012287); BEST Arabidopsis thaliana protein match is: KNOTTED-like from Arabidopsis thaliana 2 (TAIR:AT1G70510.1); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      8297241..8302651 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_180620.3 → NP_850951.2  homeobox protein knotted-1-like 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850951.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q84JS6, Q948K0, Q9LQD4, Q9LR21
      UniProtKB/TrEMBL
      A0A7G2DXN0
      Conserved Domains (4) summary
      pfam03789
      Location:224 → 245
      ELK; ELK domain
      pfam03790
      Location:85 → 123
      KNOX1; KNOX1 domain
      pfam03791
      Location:137 → 184
      KNOX2; KNOX2 domain
      pfam05920
      Location:264 → 303
      Homeobox_KN; Homeobox KN domain

    2. NM_102187.4 → NP_173752.3  homeobox protein knotted-1-like 6 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173752.3

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9VRD4, A0A654EHI7, A0A7G2DXN0
      Conserved Domains (4) summary
      pfam03789
      Location:226 → 247
      ELK; ELK domain
      pfam03790
      Location:85 → 125
      KNOX1; KNOX1 domain
      pfam03791
      Location:139 → 186
      KNOX2; KNOX2 domain
      pfam05920
      Location:266 → 305
      Homeobox_KN; Homeobox KN domain
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q84JS6.1

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