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    SAM1 S-adenosylmethionine synthetase 1 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 839501, updated on 18-Sep-2024

    Summary

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    Official Symbol
    SAM1
    Official Full Name
    S-adenosylmethionine synthetase 1
    Primary source
    TAIR:AT1G02500
    Locus tag
    AT1G02500
    See related
    Araport:AT1G02500
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtSAM1; MAT1; METK1; S-adenosylmethionine synthetase 1; S-ADENOSYLMETHIONINE SYNTHETASE-1; SAM-1
    Summary
    encodes a S-adenosylmethionine synthetase. SAM1 is regulated by protein S-nitrosylation. The covalent binding of nitric oxide (NO) to the Cys114 residue inhibits the enzyme activity.
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    Genomic context

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    See SAM1 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    2
    Sequence:
    Chromosome: 1; NC_003070.9 (518091..520495)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene tRNA-Phe Neighboring gene uncharacterized protein Neighboring gene Outward rectifying potassium channel protein Neighboring gene P-glycoprotein 11

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Differential inhibition of Arabidopsis methionine adenosyltransferases by protein S-nitrosylation. Lindermayr C, et al. J Biol Chem, 2006 Feb 17. PMID 16365035
    2. Strong cellular preference in the expression of a housekeeping gene of Arabidopsis thaliana encoding S-adenosylmethionine synthetase. Peleman J, et al. Plant Cell, 1989 Jan. PMID 2535470, Free PMC Article
    3. FERONIA receptor kinase interacts with S-adenosylmethionine synthetase and suppresses S-adenosylmethionine production and ethylene biosynthesis in Arabidopsis. Mao D, et al. Plant Cell Environ, 2015 Dec. PMID 25988356
    4. Genes involved in biosynthesis and signalisation of ethylene in Brassica oleracea and Arabidopsis thaliana: identification and genome comparative mapping of specific gene homologues. Babula D, et al. Theor Appl Genet, 2006 Feb. PMID 16311726
    5. Tip Growth Defective1 interacts with the cellulose synthase complex to regulate cellulose synthesis in Arabidopsis thaliana. Lampugnani ER, et al. PLoS One, 2024. PMID 38358988, Free PMC Article

    See all (12) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_100131.3
    NM_179246.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables methionine adenosyltransferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in S-adenosylmethionine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within ethylene biosynthetic process TAS
    Traceable Author Statement
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    located_in extracellular region HDA PubMed 
    located_in plant-type cell wall HDA PubMed 

    General protein information

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    Preferred Names
    S-adenosylmethionine synthetase 1
    NP_171751.1
    • S-adenosylmethionine synthetase 1 (SAM1); FUNCTIONS IN: methionine adenosyltransferase activity; INVOLVED IN: response to cadmium ion, response to salt stress, ethylene biosynthetic process, S-adenosylmethionine biosynthetic process; LOCATED IN: cell wall, plasma membrane, membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosylmethionine synthetase (InterPro:IPR002133), S-adenosylmethionine synthetase superfamily (InterPro:IPR022636), S-adenosylmethionine synthetase, N-terminal (InterPro:IPR022628), S-adenosylmethionine synthetase, C-terminal (InterPro:IPR022630), S-adenosylmethionine synthetase, conserved site (InterPro:IPR022631), S-adenosylmethionine synthetase, central domain (InterPro:IPR022629); BEST Arabidopsis thaliana protein match is: S-adenosylmethionine synthetase 2 (TAIR:AT4G01850.2); Has 10905 Blast hits to 10897 proteins in 2898 species: Archae - 12; Bacteria - 5497; Metazoa - 373; Fungi - 167; Plants - 706; Viruses - 1; Other Eukaryotes - 4149 (source: NCBI BLink).
    NP_849577.1
    • S-adenosylmethionine synthetase 1 (SAM1); FUNCTIONS IN: methionine adenosyltransferase activity; INVOLVED IN: response to cadmium ion, response to salt stress, ethylene biosynthetic process, S-adenosylmethionine biosynthetic process; LOCATED IN: cell wall, plasma membrane, membrane; EXPRESSED IN: 30 plant structures; EXPRESSED DURING: 17 growth stages; CONTAINS InterPro DOMAIN/s: S-adenosylmethionine synthetase (InterPro:IPR002133), S-adenosylmethionine synthetase superfamily (InterPro:IPR022636), S-adenosylmethionine synthetase, N-terminal (InterPro:IPR022628), S-adenosylmethionine synthetase, C-terminal (InterPro:IPR022630), S-adenosylmethionine synthetase, conserved site (InterPro:IPR022631), S-adenosylmethionine synthetase, central domain (InterPro:IPR022629); BEST Arabidopsis thaliana protein match is: S-adenosylmethionine synthetase 2 (TAIR:AT4G01850.2); Has 10905 Blast hits to 10897 proteins in 2898 species: Archae - 12; Bacteria - 5497; Metazoa - 373; Fungi - 167; Plants - 706; Viruses - 1; Other Eukaryotes - 4149 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      518091..520495
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_100131.3 → NP_171751.1  S-adenosylmethionine synthetase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_171751.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23686, Q941A8, Q9FEE0
      UniProtKB/TrEMBL
      A0A178WES1, A0A5S9S9C2, A0A654E6D0
      Conserved Domains (1) summary
      PLN02243
      Location:1 → 386
      PLN02243; S-adenosylmethionine synthase

    2. NM_179246.1 → NP_849577.1  S-adenosylmethionine synthetase 1 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_849577.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P23686, Q941A8, Q9FEE0
      UniProtKB/TrEMBL
      A0A178WES1, A0A5S9S9C2, A0A654E6D0
      Conserved Domains (1) summary
      PLN02243
      Location:1 → 386
      PLN02243; S-adenosylmethionine synthase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P23686.2

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