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    GLYR2 glyoxylate reductase 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838342, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GLYR2
    Official Full Name
    glyoxylate reductase 2
    Primary source
    TAIR:AT1G17650
    Locus tag
    AT1G17650
    See related
    Araport:AT1G17650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtGLYR2; F11A6.12; glyoxylate reductase 2; GLYOXYLATE REDUCTASE 2; GR2
    Summary
    Glyoxylate reductase located in chloroplasts.
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    Genomic context

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    See GLYR2 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    12
    Sequence:
    Chromosome: 1; NC_003070.9 (6069424..6072140, complement)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene Late embryogenesis abundant (LEA) hydroxyproline-rich glycoprotein family Neighboring gene Pentatricopeptide repeat (PPR-like) superfamily protein Neighboring gene RNA-binding (RRM/RBD/RNP motifs) family protein Neighboring gene CA-responsive protein Neighboring gene tRNA-Asp

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants. Hoover GJ, et al. Biochim Biophys Acta, 2013 Dec. PMID 24076009
    2. Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification. Simpson JP, et al. J Exp Bot, 2008. PMID 18495639, Free PMC Article
    3. Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms. Allan WL, et al. J Exp Bot, 2008. PMID 18495640, Free PMC Article
    4. Quantitative proteomics of a chloroplast SRP54 sorting mutant and its genetic interactions with CLPC1 in Arabidopsis. Rutschow H, et al. Plant Physiol, 2008 Sep. PMID 18633119, Free PMC Article
    5. AT_CHLORO, a comprehensive chloroplast proteome database with subplastidial localization and curated information on envelope proteins. Ferro M, et al. Mol Cell Proteomics, 2010 Jun. PMID 20061580, Free PMC Article

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Sequence and activity comparisons indicated that AtGLYR1 and AtGLYR2 possess structural features that are absent in Arabidopsis hydroxypyruvate reductases and probably account for their stronger preference for glyoxylate over hydroxypyruvate.
      Title: Identification of catalytically important amino acid residues for enzymatic reduction of glyoxylate in plants.
    2. GR1 and GR2 are involved in the regulation of Succinic semialdehyde detoxification in plants. [glyoxylate reductase 2] [AtGR2]
      Title: Gamma-hydroxybutyrate accumulation in Arabidopsis and tobacco plants is a general response to abiotic stress: putative regulation by redox balance and glyoxylate reductase isoforms.
    3. GR2 is glyoxylate reductase isoform that is localized to plastids. Kinetic studies revealed that the substrate preference for GR2 was similar to that reported for GR1. [GR2]
      Title: Identification and characterization of a plastid-localized Arabidopsis glyoxylate reductase isoform: comparison with a cytosolic isoform and implications for cellular redox homeostasis and aldehyde detoxification.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001332318.1
    NM_101628.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables NAD binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables NADP binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables glyoxylate reductase (NADPH) activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast stroma HDA PubMed 
    located_in mitochondrion ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    glyoxylate reductase 2
    NP_564030.2
    • glyoxylate reductase 2 (GLYR2); FUNCTIONS IN: phosphogluconate dehydrogenase (decarboxylating) activity, glyoxylate reductase (NADP) activity; INVOLVED IN: oxidation reduction, pentose-phosphate shunt, metabolic process; LOCATED IN: chloroplast stroma, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 13 growth stages; CONTAINS InterPro DOMAIN/s: 6-phosphogluconate dehydrogenase, NAD-binding (InterPro:IPR006115), Dehydrogenase, multihelical (InterPro:IPR013328), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), 3-hydroxyacid dehydrogenase/reductase (InterPro:IPR015815), NAD(P)-binding domain (InterPro:IPR016040); BEST Arabidopsis thaliana protein match is: glyoxylate reductase 1 (TAIR:AT3G25530.1); Has 16115 Blast hits to 16085 proteins in 2099 species: Archae - 147; Bacteria - 9815; Metazoa - 317; Fungi - 434; Plants - 311; Viruses - 1; Other Eukaryotes - 5090 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6069424..6072140 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101628.4 → NP_564030.2  glyoxylate reductase 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564030.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4I907, Q8RWF1
      UniProtKB/TrEMBL
      A0A178WM95, A0A5S9UV28, A0A654ELI4
      Conserved Domains (1) summary
      COG2084
      Location:68 → 351
      MmsB; 3-hydroxyisobutyrate dehydrogenase or related beta-hydroxyacid dehydrogenase [Lipid transport and metabolism]

    2. NM_001332318.1 → NP_001321828.1  glyoxylate reductase 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AS42, A0A654ELI4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4I907.1

    Gene LinkOut

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