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    SCL33 SC35-like splicing factor 33 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 841976, updated on 8-Dec-2024

    Summary

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    Official Symbol
    SCL33
    Official Full Name
    SC35-like splicing factor 33
    Primary source
    TAIR:AT1G55310
    Locus tag
    AT1G55310
    See related
    Araport:AT1G55310
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    At-SCL33; ATSCL33; F7A10.26; F7A10.27; F7A10_26; SC35-like splicing factor 33; SC35-LIKE SPLICING FACTOR 33; SR33
    Summary
    Encodes a SR spliceosome protein that is localized to nuclear specks, interacts with SR45 and the U1-70K protein of the U1 snRNP, has sequence similar to human SC35 protein. Barta et al (2010) have proposed a nomenclature for Serine/Arginine-Rich Protein Splicing Factors (SR proteins): Plant Cell. 2010, 22:2926.
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    Genomic context

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    See SCL33 in Genome Data Viewer
    Location:
    chromosome: 1
    Exon count:
    7
    Sequence:
    Chromosome: 1; NC_003070.9 (20629698..20633007)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene 2-oxoglutarate (2OG) and Fe(II)-dependent oxygenase superfamily protein Neighboring gene TBP-associated factor 7 Neighboring gene acyl-activating enzyme 18 Neighboring gene RNA polymerase II transcription mediator

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tissue-specific expression and dynamic organization of SR splicing factors in Arabidopsis. Fang Y, et al. Mol Biol Cell, 2004 Jun. PMID 15034145, Free PMC Article
    2. An SC35-like protein and a novel serine/arginine-rich protein interact with Arabidopsis U1-70K protein. Golovkin M, et al. J Biol Chem, 1999 Dec 17. PMID 10593939
    3. Phosphothreonine 218 is required for the function of SR45.1 in regulating flower petal development in Arabidopsis. Zhang XN, et al. Plant Signal Behav, 2014. PMID 25763493, Free PMC Article
    4. Co-localisation studies of Arabidopsis SR splicing factors reveal different types of speckles in plant cell nuclei. Lorković ZJ, et al. Exp Cell Res, 2008 Oct 15. PMID 18674533
    5. Network of interactions of a novel plant-specific Arg/Ser-rich protein, atRSZ33, with atSC35-like splicing factors. Lopato S, et al. J Biol Chem, 2002 Oct 18. PMID 12176998

    See all (11) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001036118.4
    NM_001198307.2
    NM_001333699.1
    NM_001333700.1
    NM_001333702.1
    NM_104406.6

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables RNA binding ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables nucleic acid binding IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within RNA splicing NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within mRNA splicing, via spliceosome IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in interchromatin granule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nuclear speck IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleolus HDA PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in plasma membrane HDA PubMed 

    General protein information

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    Preferred Names
    SC35-like splicing factor 33
    NP_001319238.1
    • SC35-like splicing factor 33 (SR33); FUNCTIONS IN: protein binding, RNA binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: interchromatin granule, nuclear speck, nucleolus, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: SC35-like splicing factor 30A (TAIR:AT3G13570.1); Has 74071 Blast hits to 42895 proteins in 2604 species: Archae - 973; Bacteria - 11117; Metazoa - 35835; Fungi - 6236; Plants - 4620; Viruses - 230; Other Eukaryotes - 15060 (source: NCBI BLink).
    NP_001319239.1
    • SC35-like splicing factor 33 (SR33); CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: SC35-like splicing factor 30A (TAIR:AT3G13570.1).
    NP_564685.4
    • SC35-like splicing factor 33 (SR33); FUNCTIONS IN: protein binding, RNA binding; INVOLVED IN: nuclear mRNA splicing, via spliceosome, RNA splicing; LOCATED IN: interchromatin granule, nuclear speck, nucleolus, plasma membrane; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: RNA recognition motif, RNP-1 (InterPro:IPR000504), Nucleotide-binding, alpha-beta plait (InterPro:IPR012677); BEST Arabidopsis thaliana protein match is: SC35-like splicing factor 30A (TAIR:AT3G13570.1); Has 74071 Blast hits to 42895 proteins in 2604 species: Archae - 973; Bacteria - 11117; Metazoa - 35835; Fungi - 6236; Plants - 4620; Viruses - 230; Other Eukaryotes - 15060 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      20629698..20633007
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001333701.1 → NP_001321067.1  SC35-like splicing factor 33 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W693, A0A1P8APR8

    2. NM_104406.6 → NP_564685.4  SC35-like splicing factor 33 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_564685.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      C0Z312, F4I090, F4I092, Q949P4, Q9C8A1, Q9SEU4
      UniProtKB/TrEMBL
      A0A654EK33
      Conserved Domains (2) summary
      COG0724
      Location:30 → 117
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:36 → 119
      RRM_SF; RNA recognition motif (RRM) superfamily

    3. NM_001333699.1 → NP_001319238.1  SC35-like splicing factor 33 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SEU4

    4. NM_001036118.4 → NP_001031195.4  SC35-like splicing factor 33 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001031195.4

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q9SEU4
      Conserved Domains (2) summary
      COG0724
      Location:30 → 117
      RRM; RNA recognition motif (RRM) domain [Translation, ribosomal structure and biogenesis]
      cl17169
      Location:36 → 119
      RRM_SF; RNA recognition motif (RRM) superfamily

    5. NM_001333700.1 → NP_001319239.1  SC35-like splicing factor 33 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A2H1ZEE9, A0A654EK33

    6. NM_001198307.2 → NP_001185236.2  SC35-like splicing factor 33 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6P9, A0A1P8APR4

    7. NM_001333702.1 → NP_001321066.1  SC35-like splicing factor 33 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A178W6P9, A0A1P8APR4
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SEU4.1

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