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    KIN10 SNF1 kinase homolog 10 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 821259, updated on 18-Sep-2024

    Summary

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    Official Symbol
    KIN10
    Official Full Name
    SNF1 kinase homolog 10
    Primary source
    TAIR:AT3G01090
    Locus tag
    AT3G01090
    See related
    Araport:AT3G01090
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AKIN10; SNF1 kinase homolog 10; SNF1-RELATED PROTEIN KINASE; SNF1-RELATED PROTEIN KINASE 1.1; SNRK1.1; T4P13.22; T4P13_22
    Summary
    encodes a SNF1-related protein kinase that physically interacts with SCF subunit SKP1/ASK1 and 20S proteosome subunit PAD1. It can also interact with PRL1 DWD-containing protein. Based on in vitro degradation assays and cul4cs and prl1 mutants, there is evidence that AKIN10 is degraded in a proteasome-dependent manner, and that this depends on a CUL4-PRL1 E3 ligase
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    Genomic context

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    See KIN10 in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (31145..34670, complement)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene WRKY DNA-binding protein 58 Neighboring gene Protein kinase superfamily protein Neighboring gene hypothetical protein 1 Neighboring gene Pyridoxal phosphate (PLP)-dependent transferases superfamily protein Neighboring gene ATP synthase E chain

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. AKIN10 activity as a cellular link between metabolism and circadian-clock entrainment in Arabidopsis thaliana. Sánchez-Villarreal A, et al. Plant Signal Behav, 2018 Mar 4. PMID 29231782, Free PMC Article
    2. Changes in the Phosphoproteome and Metabolome Link Early Signaling Events to Rearrangement of Photosynthesis and Central Metabolism in Salinity and Oxidative Stress Response in Arabidopsis. Chen Y, et al. Plant Physiol, 2015 Dec. PMID 26471895, Free PMC Article
    3. Plant SnRK1 Kinases: Structure, Regulation, and Function. Margalha L, et al. Exp Suppl, 2016. PMID 27812990
    4. The metabolic sensor AKIN10 modulates the Arabidopsis circadian clock in a light-dependent manner. Shin J, et al. Plant Cell Environ, 2017 Jul. PMID 28054361
    5. The AMP-Activated Protein Kinase KIN10 Is Involved in the Regulation of Autophagy in Arabidopsis. Chen L, et al. Front Plant Sci, 2017. PMID 28740502, Free PMC Article

    See all (72) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1.
      Title: Molecular mechanism of trehalose 6-phosphate inhibition of the plant metabolic sensor kinase SnRK1.
    2. The evolutionarily conserved kinase SnRK1 orchestrates resource mobilization during Arabidopsis seedling establishment.
      Title: The evolutionarily conserved kinase SnRK1 orchestrates resource mobilization during Arabidopsis seedling establishment.
    3. Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
      Title: Kinase SnRK1.1 regulates nitrate channel SLAH3 engaged in nitrate-dependent alleviation of ammonium toxicity.
    4. KIN10 promotes stomatal development through stabilization of the SPEECHLESS transcription factor.
      Title: KIN10 promotes stomatal development through stabilization of the SPEECHLESS transcription factor.
    5. SnRK1 mediates the phosphorylation and concomitant inhibition of AtCCT1.[SnRK1]
      Title: Arabidopsis CTP:phosphocholine cytidylyltransferase 1 is phosphorylated and inhibited by sucrose nonfermenting 1-related protein kinase 1 (SnRK1).
    6. SnRK1.1 is localized dynamically between the nucleus and endoplasmic reticulum (ER). ER-associated SnRK1.1 fraction might be sensing the cellular energy status, being a point of crosstalk with other ER stress regulatory pathways
      Title: Dual and dynamic intracellular localization of Arabidopsis thaliana SnRK1.1.
    7. the SnRK1-eIFiso4G1 relay controls the translation of an array of genes under hypoxia.
      Title: The SnRK1-eIFiso4G1 signaling relay regulates the translation of specific mRNAs in Arabidopsis under submergence.
    8. the role of AKIN10, on clock periodicity, is reported.
      Title: AKIN10 activity as a cellular link between metabolism and circadian-clock entrainment in Arabidopsis thaliana.
    9. KIN10 expression modulates root phenotype of Arabidopsis thaliana root system in condition of energy stress.
      Title: The influence of protein kinase KIN10 gene expression on root phenotype of Arabidopsis thaliana root system in condition of energy stress.
    10. KIN10 is required for sucrose-induced hypocotyl elongation in light/dark cycles.
      Title: The Energy-Signaling Hub SnRK1 Is Important for Sucrose-Induced Hypocotyl Elongation.
    Submit: New GeneRIF Correction See all GeneRIFs (32)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_001125074.2
    NM_110974.5
    NM_180157.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables kinase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables phosphatase binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein kinase activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables protein serine/threonine kinase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within detection of nutrient IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    acts_upstream_of_or_within developmental process involved in reproduction IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf senescence IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in plant organ development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of abscisic acid-activated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in positive regulation of autophagy IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within primary root development IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of leaf senescence IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to glucose IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to herbicide IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to hypoxia IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    involved_in response to oxidative stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in response to salt IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    involved_in starch metabolic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within sugar mediated signaling pathway IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within vegetative phase change IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in vegetative to reproductive phase transition of meristem IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in Golgi apparatus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in chloroplast IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytosol IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    part_of nuclear ubiquitin ligase complex IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    located_in nucleus IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    SNF1 kinase homolog 10
    NP_001118546.1
    • SNF1 kinase homolog 10 (KIN10); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: nuclear ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Kinase-associated KA1 (InterPro:IPR001772), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Protein kinase, Snf1-like AMPK (InterPro:IPR015741), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: SNF1 kinase homolog 11 (TAIR:AT3G29160.2); Has 30201 Blast hits to 17322 proteins in 780 species: Archae - 12; Bacteria - 1396; Metazoa - 17338; Fungi - 3422; Plants - 5037; Viruses - 0; Other Eukaryotes - 2996 (source: NCBI BLink).
    NP_566130.1
    • SNF1 kinase homolog 10 (KIN10); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: nuclear ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Protein kinase, ATP binding site (InterPro:IPR017441), Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Kinase-associated KA1 (InterPro:IPR001772), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Protein kinase, Snf1-like AMPK (InterPro:IPR015741), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636); BEST Arabidopsis thaliana protein match is: SNF1 kinase homolog 11 (TAIR:AT3G29160.2); Has 133405 Blast hits to 131080 proteins in 4728 species: Archae - 166; Bacteria - 15101; Metazoa - 49470; Fungi - 13387; Plants - 32551; Viruses - 541; Other Eukaryotes - 22189 (source: NCBI BLink).
    NP_850488.1
    • SNF1 kinase homolog 10 (KIN10); FUNCTIONS IN: protein binding, protein serine/threonine kinase activity, protein kinase activity; INVOLVED IN: in 8 processes; LOCATED IN: nuclear ubiquitin ligase complex; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ubiquitin-associated/translation elongation factor EF1B, N-terminal (InterPro:IPR000449), Protein kinase, ATP binding site (InterPro:IPR017441), Kinase-associated KA1 (InterPro:IPR001772), Serine/threonine-protein kinase domain (InterPro:IPR002290), Serine/threonine-protein kinase-like domain (InterPro:IPR017442), Protein kinase-like domain (InterPro:IPR011009), Serine/threonine-protein kinase, active site (InterPro:IPR008271), Protein kinase, Snf1-like AMPK (InterPro:IPR015741), Ubiquitin-associated/translation elongation factor EF1B, N-terminal, eukaryote (InterPro:IPR015940), Protein kinase, catalytic domain (InterPro:IPR000719), Calcium/calmodulin-dependent protein kinase-like (InterPro:IPR020636), Tyrosine-protein kinase, catalytic domain (InterPro:IPR020635); BEST Arabidopsis thaliana protein match is: SNF1 kinase homolog 11 (TAIR:AT3G29160.2); Has 133590 Blast hits to 131265 proteins in 4759 species: Archae - 166; Bacteria - 15153; Metazoa - 49555; Fungi - 13420; Plants - 32561; Viruses - 542; Other Eukaryotes - 22193 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      31145..34670 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001125074.2 → NP_001118546.1  SNF1 kinase homolog 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001118546.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6XGR0, O04728, Q38987, Q38997, Q39076, Q8RWD2
      UniProtKB/TrEMBL
      A0A178VFA5, A0A5S9X837, B9DFC1
      Conserved Domains (3) summary
      cd12122
      Location:388 → 509
      AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
      cd14335
      Location:293 → 333
      UBA_SnRK1_plant; UBA domain found in the plant sucrose nonfermenting-1-related kinase (SnRK1) proteins
      cd14079
      Location:16 → 271
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

    2. NM_110974.5 → NP_566130.1  SNF1 kinase homolog 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566130.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A6XGR0, O04728, Q38987, Q38997, Q39076, Q8RWD2
      UniProtKB/TrEMBL
      A0A178VFA5, A0A5S9X837, B9DFC1
      Conserved Domains (3) summary
      cd12122
      Location:388 → 509
      AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
      cd14335
      Location:293 → 333
      UBA_SnRK1_plant; UBA domain found in the plant sucrose nonfermenting-1-related kinase (SnRK1) proteins
      cd14079
      Location:16 → 271
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase

    3. NM_180157.1 → NP_850488.1  SNF1 kinase homolog 10 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_850488.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9X837, B9DFC1
      Conserved Domains (3) summary
      cd12122
      Location:411 → 532
      AMPKA_C; C-terminal regulatory domain of 5'-AMP-activated protein kinase (AMPK) alpha catalytic subunit
      cd14335
      Location:316 → 356
      UBA_SnRK1_plant; UBA domain found in the plant sucrose nonfermenting-1-related kinase (SnRK1) proteins
      cd14079
      Location:39 → 294
      STKc_AMPK_alpha; Catalytic domain of the Alpha subunit of the Serine/Threonine Kinase, AMP-activated protein kinase
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q38997.3

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