RAPTOR1 Regulatory-associated protein of TOR 1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: RAPTOR1
Official Full Name: Regulatory-associated protein of TOR 1
Primary source: TAIR:AT3G08850
Locus tag: AT3G08850
See related: Araport:AT3G08850
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATRAPTOR1B; RAPTOR1B
Summary: Encodes one of two Arabidopsis RAPTOR/KOG1 homologs. RAPTOR proteins are binding partners of the target of rapamycin kinase that is present in all eukaryotes and play a central role in the stimulation of cell growth and metabolism in response to nutrients. Mutants show embryo lethal phenotype which occurs at pre-globular stage. May interact with TOR kinase in a rapamycin like signaling pathway. Interacts with TOR and S6K1 in vivo. Overexpression of RAPTOR1 rendered the S6K1 osmotic stress insensitive.
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Genomic context

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See RAPTOR1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 23

Sequence:: Chromosome: 3; NC_003074.8 (2686457..2695400, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Modeling-based identification of a Raptor-binding motif present in Arabidopsis ABA receptor PYL1.
Title: Modeling-based identification of a Raptor-binding motif present in Arabidopsis ABA receptor PYL1.
mutation of Arabidopsis RAPTOR1B leads to significantly decreased levels of free jasmonic acid (JA), jasmonoyl-(L)-isoleucine (JA-Ile) as well as its biosynthetic precursor 12-oxo-phytodienoic acid (OPDA).
Title: Mutation in the Arabidopsis regulatory-associated protein TOR 1B (RAPTOR1B) leads to decreased jasmonates levels in leaf tissue.
REGULATORY-ASSOCIATED PROTEIN OF TOR 1B (RAPTOR1B) knockout lines were used to perform comprehensive hormone profiling during seed germination.
Title: Regulatory-Associated Protein of TOR 1B (RAPTOR1B) regulates hormonal switches during seed germination in Arabidopsis thaliana.
The crucial roles of RAPTOR1 in regulating growth, metabolism, and stress adaptation.
Title: RAPTOR Controls Developmental Growth Transitions by Altering the Hormonal and Metabolic Balance.
Delayed germination and seedling growth, observed in the raptor1b seeds, could be partially restored by the exogenous supply of gibberellic acid, indicating that TOR is at the center of a regulatory hub controlling seed metabolism, maturation and germination.
Title: Regulatory-associated protein of TOR (RAPTOR) alters the hormonal and metabolic composition of Arabidopsis seeds, controlling seed morphology, viability and germination potential.
A 12-amino acid core element in S6 kinase 1 (AtS6K1) was identified as an essential interacting region with Raptor1 protein.
Title: Molecular details of the Raptor-binding motif on Arabidopsis S6 kinase.
identified a 44-amino acid region at the N-terminal end of ribosomal S6 kinase 1 (S6K1) specifically interacted with Raptor1, indicating that this region may contain a functional equivalent of TOS (TOR-Signaling) motif present in mammalian TOR substrates
Title: Identification of the Raptor-binding motif on Arabidopsis S6 kinase and its use as a TOR signaling suppressor.
characterization of the two Arabidopsis orthologs of Raptor (AtRaptor1 and 2); AtRaptor1 is the most expressed isoform; mutation leads to seed abortion and to a complete arrest of embryo development at an early stage [AtRaptor1]
Title: An Arabidopsis homolog of RAPTOR/KOG1 is essential for early embryo development.
Arabidopsis RAPTOR1 (a TOR regulatory protein) interacts with the HEAT repeats of TOR and that RAPTOR1 regulates the activity of S6 kinase (S6K) in response to osmotic stress.
Title: Arabidopsis TARGET OF RAPAMYCIN interacts with RAPTOR, which regulates the activity of S6 kinase in response to osmotic stress signals.
Raptor1A Raptor1B double mutants show normal embryonic development but are unable to maintain post-embryonic meristem-driven growth.
Title: The Arabidopsis AtRaptor genes are essential for post-embryonic plant growth.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_111719.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
involved_in TOR signaling	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within embryo development ending in seed dormancy	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within maintenance of shoot apical meristem identity	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in negative regulation of autophagy	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
part_of Cul4-RING E3 ubiquitin ligase complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed
part_of TORC1 complex	IEA Inferred from Electronic Annotation more info
located_in chloroplast	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Regulatory-associated protein of TOR 1

NP_566335.1

RAPTOR1; CONTAINS InterPro DOMAIN/s: HEAT (InterPro:IPR000357), Armadillo-like helical (InterPro:IPR011989), WD40 repeat (InterPro:IPR001680), Regulatory associated protein of TOR (InterPro:IPR004083), WD40 repeat-like-containing domain (InterPro:IPR011046), WD40-repeat-containing domain (InterPro:IPR017986), WD40/YVTN repeat-like-containing domain (InterPro:IPR015943), Armadillo-type fold (InterPro:IPR016024), WD40 repeat, subgroup (InterPro:IPR019781); BEST Arabidopsis thaliana protein match is: HEAT repeat; WD domain, G-beta repeat protein protein (TAIR:AT5G01770.1); Has 7799 Blast hits to 6065 proteins in 379 species: Archae - 2; Bacteria - 1590; Metazoa - 2741; Fungi - 1618; Plants - 862; Viruses - 0; Other Eukaryotes - 986 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

2686457..2695400 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_111719.3 → NP_566335.1 Regulatory-associated protein of TOR 1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_566335.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q93YQ1, Q9SR85

UniProtKB/TrEMBL

A0A178V9S6, A0A5S9XAC1, A0A654F5A1

Conserved Domains (5) summary

sd00044
Location:640 → 667

HEAT; HEAT repeat [structural motif]

sd00039
Location:1127 → 1167

7WD40; WD40 repeat [structural motif]

pfam13646
Location:646 → 719

HEAT_2; HEAT repeats

pfam14538
Location:104 → 255

Raptor_N; Raptor N-terminal CASPase like domain

cl29593
Location:1035 → 1336

WD40; WD40 domain, found in a number of eukaryotic proteins that cover a wide variety of functions including adaptor/regulatory modules in signal transduction, pre-mRNA processing and cytoskeleton assembly; typically contains a GH dipeptide 11-24 residues from ...