AAE7 acyl-activating enzyme 7 [Arabidopsis thaliana (thale cress)] - Gene

Summary

Official Symbol: AAE7
Official Full Name: acyl-activating enzyme 7
Primary source: TAIR:AT3G16910
Locus tag: AT3G16910
See related: Araport:AT3G16910
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: AC NON-UTILIZING 1; ACETATE NON-UTILIZING 1; ACN1; acyl-activating enzyme 7
Summary: Encodes a peroxisomal protein with acetyl-CoA synthetase activity that is responsible for the activation of acetate for entry into the glyoxylate cycle.
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Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Go to nucleotide: Graphics FASTA GenBank

The role of ACN1 in lipid metabolism and gene expression in seedlings is reported.
Title: Evidence that ACN1 (acetate non-utilizing 1) prevents carbon leakage from peroxisomes during lipid mobilization in Arabidopsis seedlings.

Submit: New GeneRIF Correction

NM_112567.4

Function	Evidence Code	Pubs
enables AMP binding	ISS Inferred from Sequence or Structural Similarity more info
enables acetate-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables acetate-CoA ligase activity	IGI Inferred from Genetic Interaction more info	PubMed
enables acetate-CoA ligase activity	IMP Inferred from Mutant Phenotype more info	PubMed
enables medium-chain fatty acid-CoA ligase activity	IDA Inferred from Direct Assay more info	PubMed
enables medium-chain fatty acid-CoA ligase activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within acetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
involved_in acetate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within acetate metabolic process	IGI Inferred from Genetic Interaction more info	PubMed
involved_in butyrate metabolic process	IDA Inferred from Direct Assay more info	PubMed
acts_upstream_of_or_within glyoxylate cycle	IDA Inferred from Direct Assay more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in mitochondrion	ISM Inferred from Sequence Model more info
located_in peroxisome	HDA more info	PubMed
located_in peroxisome	IDA Inferred from Direct Assay more info	PubMed

NP_188316.1

acyl-activating enzyme 7 (AAE7); FUNCTIONS IN: acetate-CoA ligase activity, AMP binding; INVOLVED IN: glyoxylate cycle, acetate metabolic process; LOCATED IN: peroxisome; EXPRESSED IN: 23 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: AMP-dependent synthetase/ligase (InterPro:IPR000873); BEST Arabidopsis thaliana protein match is: acyl activating enzyme 1 (TAIR:AT1G20560.1); Has 73044 Blast hits to 67204 proteins in 3521 species: Archae - 1140; Bacteria - 48125; Metazoa - 3129; Fungi - 3108; Plants - 2327; Viruses - 1; Other Eukaryotes - 15214 (source: NCBI BLink).