TSO2 Ferritin/ribonucleotide reductase-like family protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: TSO2
Official Full Name: Ferritin/ribonucleotide reductase-like family protein
Primary source: TAIR:AT3G27060
Locus tag: AT3G27060
See related: Araport:AT3G27060
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATTSO2; TSO MEANING 'UGLY' IN CHINESE 2
Summary: Encodes one of the 3 ribonucleotide reductase (RNR) small subunit genes. TSO2 transcription occurs predominantly at the S-phase of the cell cycle and its expression pattern is consistent with its role in dNDP biosynthesis during DNA replication in actively dividing cells. Critical for cell cycle progression, DNA damage repair and plant development.
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Genomic context

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See TSO2 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 2

Sequence:: Chromosome: 3; NC_003074.8 (9979841..9981620, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

These results therefore suggest that all three individual RNR2-like catalytic subunit genes participate in unique aspects of the cellular response to DNA damage in Arabidopsis.
Title: Ribonucleotide reductase regulation in response to genotoxic stress in Arabidopsis.

Submit: New GeneRIF Correction

Pathways from PubChem

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_113620.4

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within DNA repair	TAS Traceable Author Statement more info	PubMed
acts_upstream_of_or_within DNA replication	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within multicellular organism development	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within programmed cell death	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytoplasm	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: Ferritin/ribonucleotide reductase-like family protein

NP_189342.1

TSO MEANING 'UGLY' IN CHINESE 2 (TSO2); FUNCTIONS IN: oxidoreductase activity, transition metal ion binding, ribonucleoside-diphosphate reductase activity; INVOLVED IN: in 6 processes; LOCATED IN: cellular_component unknown; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Ribonucleotide reductase-related (InterPro:IPR012348), Ribonucleotide reductase (InterPro:IPR000358), Ferritin/ribonucleotide reductase-like (InterPro:IPR009078); BEST Arabidopsis thaliana protein match is: ribonucleotide reductase 2A (TAIR:AT3G23580.1); Has 9355 Blast hits to 9350 proteins in 2299 species: Archae - 34; Bacteria - 4270; Metazoa - 263; Fungi - 240; Plants - 185; Viruses - 729; Other Eukaryotes - 3634 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

9979841..9981620 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_113620.4 → NP_189342.1 Ferritin/ribonucleotide reductase-like family protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_189342.1

Status: REVIEWED

UniProtKB/Swiss-Prot

P0DKH3, Q9LSD0

UniProtKB/TrEMBL

A0A178VJE9, A0A5S9XG61, A0A654G6Q7

Conserved Domains (1) summary

PLN02492
Location:7 → 332

PLN02492; ribonucleoside-diphosphate reductase