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    GAPA glyceraldehyde 3-phosphate dehydrogenase A subunit [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 822277, updated on 18-Sep-2024

    Summary

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    Official Symbol
    GAPA
    Official Full Name
    glyceraldehyde 3-phosphate dehydrogenase A subunit
    Primary source
    TAIR:AT3G26650
    Locus tag
    AT3G26650
    See related
    Araport:AT3G26650
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    GAPA-1; glyceraldehyde 3-phosphate dehydrogenase A subunit; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE A SUBUNIT; GLYCERALDEHYDE 3-PHOSPHATE DEHYDROGENASE A SUBUNIT 1; GLYCERALDEHYDE-3-PHOSPHATE DEHYDROGENASE A SUBUNIT
    Summary
    Encodes one of the two subunits forming the photosynthetic glyceraldehyde-3-phosphate dehydrogenase (GAPDH) and as such a constituent of the supramolecular complex with phosphoribulokinase (PRK) thought to be linked by a small peptide encoded by CP12-2. GapA-1 is coordinately expressed by light with PRK and CP12-2. The enzyme activity, tested in leaf protein extracts dropped significantly after external sucrose treatment for the photosynthetic GAPDH (NADPH-dependent) but not for the cytosolic GAPDH (NADH-dependent).
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    Genomic context

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    See GAPA in Genome Data Viewer
    Location:
    chromosome: 3
    Exon count:
    5
    Sequence:
    Chromosome: 3; NC_003074.8 (9794862..9797045)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene Tetratricopeptide repeat (TPR)-like superfamily protein Neighboring gene LOB domain-containing protein 23 Neighboring gene Transducin/WD40 repeat-like superfamily protein Neighboring gene LOB domain-containing protein 24 Neighboring gene magnesium transporter, putative (DUF803) Neighboring gene DNA repair metallo-beta-lactamase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase. Baek D, et al. Phytochemistry, 2008 Jan. PMID 17854848
    2. Deciphering the Binding of Salicylic Acid to Arabidopsis thaliana Chloroplastic GAPDH-A1. Pokotylo I, et al. Int J Mol Sci, 2020 Jun 30. PMID 32630078, Free PMC Article
    3. Conformational selection and folding-upon-binding of intrinsically disordered protein CP12 regulate photosynthetic enzymes assembly. Fermani S, et al. J Biol Chem, 2012 Jun 15. PMID 22514274, Free PMC Article
    4. Spontaneous assembly of photosynthetic supramolecular complexes as mediated by the intrinsically unstructured protein CP12. Marri L, et al. J Biol Chem, 2008 Jan 25. PMID 17947231
    5. Reconstitution and properties of the recombinant glyceraldehyde-3-phosphate dehydrogenase/CP12/phosphoribulokinase supramolecular complex of Arabidopsis. Marri L, et al. Plant Physiol, 2005 Nov. PMID 16258009, Free PMC Article

    See all (27) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Deciphering the Binding of Salicylic Acid to Arabidopsis thaliana Chloroplastic GAPDH-A1.
      Title: Deciphering the Binding of Salicylic Acid to Arabidopsis thaliana Chloroplastic GAPDH-A1.
    2. GAPDH controls generation of H(2)O(2) by Bax and heat shock, which in turn suppresses cell death in yeast and plant cells
      Title: Suppression of reactive oxygen species by glyceraldehyde-3-phosphate dehydrogenase.
    Submit: New GeneRIF Correction

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_113576.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables glyceraldehyde-3-phosphate dehydrogenase (NADP+) (phosphorylating) activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    Process Evidence Code Pubs
    involved_in glucose metabolic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in reductive pentose-phosphate cycle IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within reductive pentose-phosphate cycle NAS
    Non-traceable Author Statement
    more info
    		 PubMed 
    acts_upstream_of_or_within response to cold IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to light stimulus IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to sucrose IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in chloroplast stroma ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    located_in chloroplast thylakoid membrane HDA PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in stromule IDA
    Inferred from Direct Assay
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    glyceraldehyde 3-phosphate dehydrogenase A subunit
    NP_566796.2
    • glyceraldehyde 3-phosphate dehydrogenase A subunit (GAPA); FUNCTIONS IN: protein binding, glyceraldehyde-3-phosphate dehydrogenase activity; INVOLVED IN: in 6 processes; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Glyceraldehyde 3-phosphate dehydrogenase subfamily (InterPro:IPR000173), Glyceraldehyde 3-phosphate dehydrogenase family (InterPro:IPR020831), Glyceraldehyde-3-phosphate dehydrogenase, type I (InterPro:IPR006424), Glyceraldehyde 3-phosphate dehydrogenase, active site (InterPro:IPR020830), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain (InterPro:IPR020829), Glyceraldehyde 3-phosphate dehydrogenase, catalytic domain, subgroup (InterPro:IPR020832), Glyceraldehyde 3-phosphate dehydrogenase, NAD(P) binding domain (InterPro:IPR020828); BEST Arabidopsis thaliana protein match is: glyceraldehyde 3-phosphate dehydrogenase A subunit 2 (TAIR:AT1G12900.1); Has 24893 Blast hits to 24884 proteins in 6192 species: Archae - 47; Bacteria - 10870; Metazoa - 2226; Fungi - 2780; Plants - 3758; Viruses - 0; Other Eukaryotes - 5212 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      9794862..9797045
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_113576.4 → NP_566796.2  glyceraldehyde 3-phosphate dehydrogenase A subunit [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_566796.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      P25856, Q41184, Q9LSE6
      UniProtKB/TrEMBL
      A0A178VLF6, A0A5S9XG12, A0A7G2ET00
      Conserved Domains (1) summary
      PLN03096
      Location:10 → 396
      PLN03096; glyceraldehyde-3-phosphate dehydrogenase A; Provisional
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P25856.3

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