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    MP Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 838573, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MP
    Official Full Name
    Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein
    Primary source
    TAIR:AT1G19850
    Locus tag
    AT1G19850
    See related
    Araport:AT1G19850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    ARF5; AUXIN RESPONSE FACTOR 5; F6F9.10; F6F9_10; IAA24; indole-3-acetic acid inducible 24; MONOPTEROS; TRANSCRIPTION FACTOR IAA24
    Summary
    Encodes a transcription factor (IAA24) mediating embryo axis formation and vascular development. Similar to AUXIN RESPONSIVE FACTOR 1 (ARF1) shown to bind to auxin responsive elements (AREs), and to the maize transcriptional activator VIVIPAROUS 1(VP1). In situ hybridization shows expression in provascular tissue of embryos, the emerging shoot primordia, then is restricted to provascular tissue, and in the root central vascular cylinder.
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    Genomic context

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    Location:
    chromosome: 1
    Exon count:
    13
    Sequence:
    Chromosome: 1; NC_003070.9 (6886669..6891404)

    Chromosome 1 - NC_003070.9Genomic Context describing neighboring genes Neighboring gene filament-like protein (DUF869) Neighboring gene SAUR-like auxin-responsive protein family Neighboring gene Zinc finger C-x8-C-x5-C-x3-H type family protein Neighboring gene IQ-domain 32 Neighboring gene Regulator of chromosome condensation (RCC1) family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003070.9

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Multiple MONOPTEROS-dependent pathways are involved in leaf initiation. Schuetz M, et al. Plant Physiol, 2008 Oct. PMID 18685044, Free PMC Article
    2. Characterization of an allelic series in the MONOPTEROS gene of Arabidopsis. Odat O, et al. Genesis, 2014 Feb. PMID 24281793
    3. Distinct subclades of Aux/IAA genes are direct targets of ARF5/MP transcriptional regulation. Krogan NT, et al. New Phytol, 2014 Nov. PMID 25145395
    4. Irrepressible MONOPTEROS/ARF5 promotes de novo shoot formation. Ckurshumova W, et al. New Phytol, 2014 Nov. PMID 25274430
    5. A dominant mutation reveals asymmetry in MP/ARF5 function along the adaxial-abaxial axis of shoot lateral organs. Krogan NT, et al. Plant Signal Behav, 2012 Aug. PMID 22751359, Free PMC Article

    See all (49) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12.
      Title: ARF4 regulates shoot regeneration through coordination with ARF5 and IAA12.
    2. Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17.
      Title: Determinants of PB1 Domain Interactions in Auxin Response Factor ARF5 and Repressor IAA17.
    3. Auxin signaling in stem cells is mediated, at least in part, by AUXIN RESPONSE FACTOR 5/MONOPTEROS (ARF5/MP), which directly represses the transcription of DORNROSCHEN/ENHANCER OF SHOOT REGENERATION 1 (DRN/ESR1). DRN expressed in stem cells positively regulates CLAVATA3 (CLV3) expression and has important meristematic functions.
      Title: A Molecular Framework for Auxin-Controlled Homeostasis of Shoot Stem Cells in Arabidopsis.
    4. Adaxial-expressed MONOPTEROS (MP) and abaxial-enriched auxin together act as positional cues for patterning the WOX domain. MP directly binds to the WOX1 and PRS promoters and activates their expression.
      Title: Spatial Auxin Signaling Controls Leaf Flattening in Arabidopsis.
    5. MP plays a critical role in Arabidopsis embryonic root initiation.
      Title: Auxin response cell-autonomously controls ground tissue initiation in the early Arabidopsis embryo.
    6. TIR1/AFB-Aux/IAA auxin perception mediates rapid cell wall acidification and growth of Arabidopsis hypocotyls.
      Title: TIR1/AFB-Aux/IAA auxin perception mediates rapid cell wall acidification and growth of Arabidopsis hypocotyls.
    7. activating a steroid-inducible variant of the auxin response factor (ARF) MONOPTEROS (MP) is sufficient to restore patterning and PIN gene expression.
      Title: The auxin response factor MONOPTEROS controls meristem function and organogenesis in both the shoot and root through the direct regulation of PIN genes.
    8. These findings reveal a patterning module in plants that determines organ position by orienting transport of the hormone auxin toward cells with high levels of MP-mediated auxin signaling.
      Title: Auxin Acts through MONOPTEROS to Regulate Plant Cell Polarity and Pattern Phyllotaxis.
    9. In this study, it is shown that MONOPTEROS (MP) directly activates the Dof5.8 promoter. Phenotypic analysis with the mp dof5.8 double mutants revealed that mutations within Dof5.8 enhanced the phenotype of a weak allele of mp.
      Title: MONOPTEROS directly activates the auxin-inducible promoter of the Dof5.8 transcription factor gene in Arabidopsis thaliana leaf provascular cells.
    10. Analyses of the expression pattern of ARF7 and ARF5 targets suggest that this patterning mechanism controls flanking and central zone specification in Arabidopsis LR primordia.
      Title: Inference of the Arabidopsis lateral root gene regulatory network suggests a bifurcation mechanism that defines primordia flanking and central zones.
    Submit: New GeneRIF Correction See all GeneRIFs (26)

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    Miscellaneous features

    • Loc: 6887019-6887057 AT1G19850.uORF4
    • Loc: 6887047-6887121 AT1G19850.uORF1
    • Loc: 6887080-6887121 AT1G19850.uORF3
    • Loc: 6887146-6887196 AT1G19850.uORF2
    NM_001332415.1
    NM_101840.3

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables DNA-binding transcription factor activity ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 
    enables DNA-binding transcription factor activity TAS
    Traceable Author Statement
    more info
    		 PubMed 
    enables identical protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables transcription cis-regulatory region binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within embryo development ending in seed dormancy IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within flower development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within leaf vascular tissue pattern formation IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within longitudinal axis specification IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within meristem development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    involved_in regulation of DNA-templated transcription IEA
    Inferred from Electronic Annotation
    more info
    		  
    acts_upstream_of_or_within regulation of DNA-templated transcription IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to auxin IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within root development IGI
    Inferred from Genetic Interaction
    more info
    		 PubMed 
    acts_upstream_of_or_within xylem and phloem pattern formation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein
    NP_173414.1
    • MONOPTEROS (MP); FUNCTIONS IN: sequence-specific DNA binding transcription factor activity, promoter binding; INVOLVED IN: in 8 processes; LOCATED IN: nucleus, membrane; EXPRESSED IN: 21 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Aux/IAA-ARF-dimerisation (InterPro:IPR011525), Transcriptional factor B3 (InterPro:IPR003340), AUX/IAA protein (InterPro:IPR003311), Auxin response factor (InterPro:IPR010525); BEST Arabidopsis thaliana protein match is: auxin response factor 19 (TAIR:AT1G19220.1); Has 2568 Blast hits to 2208 proteins in 92 species: Archae - 0; Bacteria - 11; Metazoa - 4; Fungi - 3; Plants - 2536; Viruses - 0; Other Eukaryotes - 14 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003070.9 Reference assembly

      Range
      6886669..6891404
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_101840.3 → NP_173414.1  Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_173414.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      A5YYU1, A5YYU8, A5YYW1, A5YYW2, O64965, P93024, Q33DU8, Q9FXI3
      UniProtKB/TrEMBL
      A0A178W993, A0A5S9V5Z9
      Conserved Domains (3) summary
      smart01019
      Location:158 → 259
      B3; B3 DNA binding domain
      pfam02309
      Location:805 → 873
      AUX_IAA; AUX/IAA family
      pfam06507
      Location:290 → 367
      Auxin_resp; Auxin response factor

    2. NM_001332415.1 → NP_001321214.1  Transcriptional factor B3 family protein / auxin-responsive factor AUX/IAA-like protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8AQ60
      Conserved Domains (3) summary
      smart01019
      Location:147 → 248
      B3; B3 DNA binding domain
      pfam02309
      Location:794 → 862
      AUX_IAA; AUX/IAA family
      pfam06507
      Location:279 → 356
      Auxin_resp; Auxin response factor
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    P93024.3

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