CCT RNA polymerase II transcription mediator [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CCT
Official Full Name: RNA polymerase II transcription mediator
Primary source: TAIR:AT4G00450
Locus tag: AT4G00450
See related: Araport:AT4G00450
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: A_IG005I10.24; A_IG005I10_24; CENTER CITY; CRP; CRYPTIC PRECOCIOUS; F5I10.24; F5I10_24; GCT; GRAND CENTRAL; MED12; mediator 12
Summary: Encodes the Arabidopsis homolog of the transcriptional regulator MED12, is dynamically expressed during embryogenesis and regulates both developmental timing and the radial pattern formation. Involved in flowering time. The mutant enhances the expression of the flowering time (FT) gene. A knockout mutant of this gene showed late-flowering phenotype.
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Genomic context

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See CCT in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 13

Sequence:: Chromosome: 4; NC_003075.7 (200874..211309)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis.
Title: Loss-of-function of MEDIATOR 12 or 13 subunits causes the swelling of root hairs in response to sucrose and abscisic acid in Arabidopsis.
The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.
Title: The characterization of Mediator 12 and 13 as conditional positive gene regulators in Arabidopsis.
CCT-deficient cells exhibited depletion of cortical microtubules, accompanied by a reduction in cellular alpha- and beta-tubulin levels due to protein degradation. Cycloheximide-chase assays suggested that CCT is involved in the folding of tubulins in plants.
Title: Functional characterization of chaperonin containing T-complex polypeptide-1 and its conserved and novel substrates in Arabidopsis.
med12 and med13 single mutants exhibit shoot and root phenotypes consistent with altered auxin homeostasis including altered primary root growth, lateral root development, and root hair elongation.
Title: The MEDIATOR genes MED12 and MED13 control Arabidopsis root system configuration influencing sugar and auxin responses.
GCT and CCT coordinate vegetative and floral transitions by repressing the repressors miR156 and FLC.
Title: The Arabidopsis Mediator CDK8 module genes CCT (MED12) and GCT (MED13) are global regulators of developmental phase transitions.
MED12/CRP is a novel flowering regulator which suppresses FLC expression, promotes FT and TSF expression and up-regulates SOC1 and FUL mainly in an FT-dependent manner under long-day conditions.
Title: CRYPTIC PRECOCIOUS/MED12 is a novel flowering regulator with multiple target steps in Arabidopsis.
MED13 and MED12 regulate pattern formation during Arabidopsis embryogenesis by transiently repressing a transcriptional program that interferes with this process. [MED12]
Title: The MED12-MED13 module of Mediator regulates the timing of embryo patterning in Arabidopsis.

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General gene information

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Markers

MASC_STS12664 (e-PCR)
- UniSTS:258561

NM_001340249.1

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables transcription coregulator activity	IEA Inferred from Electronic Annotation more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within photoperiodism, flowering	NAS Non-traceable Author Statement more info
acts_upstream_of_or_within regulation of development, heterochronic	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of radial pattern formation	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in regulation of transcription by RNA polymerase II	IEA Inferred from Electronic Annotation more info

Component	Evidence Code	Pubs
part_of mediator complex	IEA Inferred from Electronic Annotation more info
located_in nucleus	IDA Inferred from Direct Assay more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: RNA polymerase II transcription mediator

NP_001319832.1

CENTER CITY (CCT); FUNCTIONS IN: RNA polymerase II transcription mediator activity; INVOLVED IN: photoperiodism, flowering, regulation of development, heterochronic, regulation of radial pattern formation; LOCATED IN: mediator complex, chloroplast; EXPRESSED IN: 22 plant structures; EXPRESSED DURING: 14 growth stages; CONTAINS InterPro DOMAIN/s: Mediator complex, subunit Med12 (InterPro:IPR019035); Has 216 Blast hits to 184 proteins in 75 species: Archae - 0; Bacteria - 0; Metazoa - 42; Fungi - 65; Plants - 86; Viruses - 0; Other Eukaryotes - 23 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

200874..211309

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_001340250.1 → NP_001329123.1 RNA polymerase II transcription mediator [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JHC0, H3K2Y6, O23057

UniProtKB/TrEMBL

A0A178UXU4
NM_001340251.1 → NP_001329124.1 RNA polymerase II transcription mediator [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JHC0, H3K2Y6, O23057

UniProtKB/TrEMBL

A0A178UXU4
NM_001340249.1 → NP_001319832.1 RNA polymerase II transcription mediator [Arabidopsis thaliana]

Status: REVIEWED

UniProtKB/Swiss-Prot

F4JHC0, H3K2Y6, O23057

UniProtKB/TrEMBL

A0A178UXU4