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    MS5 Tetratricopeptide repeat (TPR)-like superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827838, updated on 18-Sep-2024

    Summary

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    Official Symbol
    MS5
    Official Full Name
    Tetratricopeptide repeat (TPR)-like superfamily protein
    Primary source
    TAIR:AT4G20900
    Locus tag
    AT4G20900
    See related
    Araport:AT4G20900
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    MALE-STERILE 5; T13K14.60; T13K14_60; TDM1
    Summary
    ms5 mutants are male sterile, pollen tetrads undergo an extra round of division after meiosis II without chromosome replication, resulting in chromosome abnormalities. Gene product has some similarity to SCP1, a rat synaptonemal complex protein.
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    Genomic context

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    See MS5 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    5
    Sequence:
    Chromosome: 4; NC_003075.7 (11184103..11185844, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene miscRNA Neighboring gene ethylene-responsive nuclear protein / ethylene-regulated nuclear protein (ERT2) Neighboring gene tubulin beta-9 chain Neighboring gene double-stranded RNA binding protein-related / DsRBD protein-like protein Neighboring gene double-stranded RNA-binding domain (DsRBD)-containing protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation. Cairo A, et al. Science, 2022 Aug 5. PMID 35926014
    2. Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds. Wang X, et al. FEBS Lett, 2020 Aug. PMID 32415887
    3. TDM1 Regulation Determines the Number of Meiotic Divisions. Cifuentes M, et al. PLoS Genet, 2016 Feb. PMID 26871453, Free PMC Article
    4. The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis. Andreuzza S, et al. PLoS Genet, 2015 Sep. PMID 26348709, Free PMC Article
    5. Cloning and characterization of MS5 from Arabidopsis: a gene critical in male meiosis. Glover J, et al. Plant J, 1998 Aug. PMID 9750346

    See all (8) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation.
      Title: Meiotic exit in Arabidopsis is driven by P-body-mediated inhibition of translation.
    2. Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds.
      Title: Structural analysis of the meiosis-related protein MS5 reveals non-canonical papain enhancement by cystatin-like folds.
    3. TDM1 is an APC/C component whose function is to ensure meiosis termination.
      Title: TDM1 Regulation Determines the Number of Meiotic Divisions.
    4. identify two genes TDM1 and JAS with critical functions in cell cycle transitions and spindle organization in male meiosis, as DUET targets, with TDM1 being a direct target
      Title: The Chromatin Protein DUET/MMD1 Controls Expression of the Meiotic Gene TDM1 during Male Meiosis in Arabidopsis.
    5. Results propose a model that meiotic progression in Arabidopsis pollen mother cells is driven by a yet to be identified cyclin-CDK activity that is modulated by regulatory interactions between TDM1, SMG7, and TAM (CYCA1;2)
      Title: Meiotic progression in Arabidopsis is governed by complex regulatory interactions between SMG7, TDM1, and the meiosis I-specific cyclin TAM.
    Submit: New GeneRIF Correction

    General gene information

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    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    involved_in male meiotic nuclear division IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in meiotic cell cycle IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    acts_upstream_of_or_within microsporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in microsporogenesis IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in negative regulation of translation IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in P-body IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  
    located_in nucleus ISS
    Inferred from Sequence or Structural Similarity
    more info
    		 PubMed 

    General protein information

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    Preferred Names
    Tetratricopeptide repeat (TPR)-like superfamily protein
    NP_193822.1
    • MALE-STERILE 5 (MS5); BEST Arabidopsis thaliana protein match is: Tetratricopeptide repeat (TPR)-like superfamily protein (TAIR:AT5G44330.1); Has 181 Blast hits to 179 proteins in 26 species: Archae - 0; Bacteria - 4; Metazoa - 2; Fungi - 0; Plants - 166; Viruses - 5; Other Eukaryotes - 4 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11184103..11185844 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001341460.1 → NP_001328331.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65310, Q9SBJ5, Q9SUC3
      UniProtKB/TrEMBL
      A0A178V3U6, A0A7G2F4R7
      Conserved Domains (2) summary
      COG0457
      Location:97 → 277
      TPR; Tetratricopeptide (TPR) repeat [General function prediction only]
      sd00006
      Location:190 → 220
      TPR; TPR repeat [structural motif]

    2. NM_118208.1 → NP_193822.1  Tetratricopeptide repeat (TPR)-like superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193822.1

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A5S9XUA8, A0A7G2F4R7
      Conserved Domains (1) summary
      sd00006
      Location:190 → 236
      TPR; TPR repeat [structural motif]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q9SUC3.2

    Gene LinkOut

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