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    TPP2 tripeptidyl peptidase ii [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 827833, updated on 18-Sep-2024

    Summary

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    Official Symbol
    TPP2
    Official Full Name
    tripeptidyl peptidase ii
    Primary source
    TAIR:AT4G20850
    Locus tag
    AT4G20850
    See related
    Araport:AT4G20850
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    T13K14.10; T13K14_10; tripeptidyl peptidase ii
    Summary
    Tripeptidyl Peptidase II. Ser protease that assembles into a large oligomeric complex containing two proteins of 153 and 142 kD that are derived from a single TPP2 gene, with the smaller version missing part of the C-terminal end. Not essential, based on the lack of phenotype of a T-DNA disruption mutant.
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    Genomic context

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    See TPP2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    34
    Sequence:
    Chromosome: 4; NC_003075.7 (11160721..11170071, complement)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene FAD-binding Berberine family protein Neighboring gene uncharacterized protein Neighboring gene FAD-binding Berberine family protein Neighboring gene FAD-binding Berberine family protein Neighboring gene fatty acid hydroxylase 2 Neighboring gene miscRNA

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis. Book AJ, et al. Plant Physiol, 2005 Jun. PMID 15908606, Free PMC Article
    2. Identification of multiple salicylic acid-binding proteins using two high throughput screens. Manohar M, et al. Front Plant Sci, 2014. PMID 25628632, Free PMC Article
    3. Isolation of intact vacuoles and proteomic analysis of tonoplast from suspension-cultured cells of Arabidopsis thaliana. Shimaoka T, et al. Plant Cell Physiol, 2004 Jun. PMID 15215502
    4. High heterogeneity within the ribosomal proteins of the Arabidopsis thaliana 80S ribosome. Giavalisco P, et al. Plant Mol Biol, 2005 Mar. PMID 15821981
    5. Proteomic analysis of the 26S proteasome reveals its direct interaction with transit peptides of plastid protein precursors for their degradation. Sako K, et al. J Proteome Res, 2014 Jul 3. PMID 24846764

    See all (14) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. The purification and characterization of tripeptidyl peptidase II from Arabidopsis thaliana is reported.
      Title: Tripeptidyl peptidase II. An oligomeric protease complex from Arabidopsis.
    Submit: New GeneRIF Correction

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    NM_118203.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables mRNA binding IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    enables salicylic acid binding HDA PubMed 
    enables serine-type endopeptidase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables tripeptidyl-peptidase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in chloroplast HDA PubMed 
    located_in cytoplasm IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    located_in cytoplasm ISM
    Inferred from Sequence Model
    more info
    		  
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in cytosolic ribosome HDA PubMed 
    located_in plant-type vacuole HDA PubMed 
    located_in vacuole HDA PubMed 

    General protein information

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    Preferred Names
    tripeptidyl peptidase ii
    NP_193817.2
    • tripeptidyl peptidase ii (TPP2); FUNCTIONS IN: tripeptidyl-peptidase activity; INVOLVED IN: proteolysis; LOCATED IN: in 6 components; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Peptidase S8/S53, subtilisin/kexin/sedolisin (InterPro:IPR000209), Peptidase S8, subtilisin-related (InterPro:IPR015500), Peptidase S8/S53, subtilisin, active site (InterPro:IPR022398), Peptidase S8A, tripeptidyl peptidase II (InterPro:IPR022229); Has 6394 Blast hits to 6195 proteins in 1270 species: Archae - 226; Bacteria - 4362; Metazoa - 666; Fungi - 272; Plants - 126; Viruses - 0; Other Eukaryotes - 742 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11160721..11170071 complement
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118203.4 → NP_193817.2  tripeptidyl peptidase ii [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193817.2

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      F4JVN6, Q8L640, Q9SUC7
      UniProtKB/TrEMBL
      A0A178UVT6, A0A654FR75
      Conserved Domains (2) summary
      cd04857
      Location:116 → 598
      Peptidases_S8_Tripeptidyl_Aminopeptidase_II; Peptidase S8 family domain in Tripeptidyl aminopeptidases_II
      pfam12580
      Location:897 → 1080
      TPPII; Tripeptidyl peptidase II
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    F4JVN6.1

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