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    LOL2 lsd one like 2 [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 828248, updated on 18-Sep-2024

    Summary

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    Official Symbol
    LOL2
    Official Full Name
    lsd one like 2
    Primary source
    TAIR:AT4G21610
    Locus tag
    AT4G21610
    See related
    Araport:AT4G21610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    F18E5.230; F18E5_230; lsd one like 2
    Summary
    Contains the same novel zinc finger motif with LSD1, a negative regulator of cell death and defense response. Due to differential splicing, it encodes two different proteins, one of which contains an additional, putative DNA binding motif. Northern analysis demonstrated that LOL2 transcripts containing the additional DNA binding motif are predominantly upregulated after treatment with both virulent and avirulent Pseudomonas syringae pv maculicola strains.
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    Genomic context

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    See LOL2 in Genome Data Viewer
    Location:
    chromosome: 4
    Exon count:
    3
    Sequence:
    Chromosome: 4; NC_003075.7 (11488976..11490423)

    Chromosome 4 - NC_003075.7Genomic Context describing neighboring genes Neighboring gene endonuclease 5 Neighboring gene miscRNA Neighboring gene glycine-rich protein Neighboring gene Subtilase family protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003075.7

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. Antagonistic control of oxidative stress-induced cell death in Arabidopsis by two related, plant-specific zinc finger proteins. Epple P, et al. Proc Natl Acad Sci U S A, 2003 May 27. PMID 12732715, Free PMC Article
    2. CrY2H-seq: a massively multiplexed assay for deep-coverage interactome mapping. Wanamaker SA, et al. Nat Methods, 2017 Aug. PMID 28650476, Free PMC Article
    3. Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Mayer K, et al. Nature, 1999 Dec 16. PMID 10617198

    GeneRIFs: Gene References Into Functions

    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001341506.1
    NM_118281.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables protein binding IPI
    Inferred from Physical Interaction
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within response to bacterium IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    lsd one like 2
    NP_193892.1
    • lsd one like 2 (LOL2); CONTAINS InterPro DOMAIN/s: Zinc finger, LSD1-type (InterPro:IPR005735); BEST Arabidopsis thaliana protein match is: lsd one like 1 (TAIR:AT1G32540.1); Has 291 Blast hits to 191 proteins in 35 species: Archae - 0; Bacteria - 0; Metazoa - 0; Fungi - 2; Plants - 255; Viruses - 0; Other Eukaryotes - 34 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003075.7 Reference assembly

      Range
      11488976..11490423
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_118281.4 → NP_193892.1  lsd one like 2 [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_193892.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      O65426
      UniProtKB/TrEMBL
      A0A178UWB7, A0A5S9XUI2
      Conserved Domains (2) summary
      TIGR01053
      Location:60 → 90
      LSD1; zinc finger domain, LSD1 subclass
      pfam06943
      Location:101 → 125
      zf-LSD1; LSD1 zinc finger

    2. NM_001341506.1 → NP_001329633.1  lsd one like 2 [Arabidopsis thaliana]

      Status: REVIEWED

      UniProtKB/TrEMBL
      A0A1P8B8B2
      Conserved Domains (2) summary
      pfam06943
      Location:101 → 125
      zf-LSD1; LSD1 zinc finger
      cl26935
      Location:60 → 90
      zf-LSD1; LSD1 zinc finger
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    O65426.1

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