Pycr3 pyrroline-5-carboxylate reductase 3 [Mus musculus (house mouse)] - Gene

Summary

Official Symbol: Pycr3provided by MGI
Official Full Name: pyrroline-5-carboxylate reductase 3provided by MGI
Primary source: MGI:MGI:1913444
See related: Ensembl:ENSMUSG00000022571 AllianceGenome:MGI:1913444
Gene type: protein coding
RefSeq status: VALIDATED
Organism: Mus musculus
Lineage: Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Glires; Rodentia; Myomorpha; Muroidea; Muridae; Murinae; Mus; Mus
Also known as: Pycrl; 1110058B13Rik; 2700073G24Rik
Summary: Predicted to enable cytidine deaminase activity and pyrroline-5-carboxylate reductase activity. Predicted to be involved in L-proline biosynthetic process. Predicted to act upstream of or within cytidine deamination. Predicted to be located in cytosol; intercellular bridge; and mitotic spindle. Orthologous to human PYCR3 (pyrroline-5-carboxylate reductase 3). [provided by Alliance of Genome Resources, Dec 2024]
Expression: Ubiquitous expression in large intestine adult (RPKM 50.1), duodenum adult (RPKM 48.8) and 27 other tissues See more
Orthologs: human all
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Genomic context

Location:: 15 D3; 15 35.09 cM

Exon count:: 7

Annotation release	Status	Assembly	Chr	Location
RS_2024_02	current	GRCm39 (GCF_000001635.27)	15	NC_000081.7 (75788319..75793369, complement)
108.20200622	previous assembly	GRCm38.p6 (GCF_000001635.26)	15	NC_000081.6 (75916463..75921560, complement)

Chromosome 15 - NC_000081.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Genomic Sequence:

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Expression

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See details

Project title: Mouse ENCODE transcriptome data
Description: RNA profiling data sets generated by the Mouse ENCODE project.
BioProject: PRJNA66167
Publication: PMID 25409824
Analysis date: n/a

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

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Variation

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Alleles

Alleles of this type are documented at Mouse Genome Informatics (MGI)

Endonuclease-mediated (2)
Targeted (1)

Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Gene Ontology Provided by MGI

Function	Evidence Code	Pubs
enables cytidine deaminase activity	ISO Inferred from Sequence Orthology more info
enables pyrroline-5-carboxylate reductase activity	IBA Inferred from Biological aspect of Ancestor more info
enables pyrroline-5-carboxylate reductase activity	ISO Inferred from Sequence Orthology more info
enables pyrroline-5-carboxylate reductase activity	ISS Inferred from Sequence or Structural Similarity more info

Process	Evidence Code	Pubs
involved_in L-proline biosynthetic process	IBA Inferred from Biological aspect of Ancestor more info
involved_in L-proline biosynthetic process	IEA Inferred from Electronic Annotation more info
involved_in L-proline biosynthetic process	ISO Inferred from Sequence Orthology more info
involved_in L-proline biosynthetic process	ISS Inferred from Sequence or Structural Similarity more info
acts_upstream_of_or_within cytidine deamination	ISO Inferred from Sequence Orthology more info

Component	Evidence Code	Pubs
located_in cytosol	ISO Inferred from Sequence Orthology more info
located_in cytosol	ISS Inferred from Sequence or Structural Similarity more info
located_in intercellular bridge	IEA Inferred from Electronic Annotation more info
located_in intercellular bridge	ISO Inferred from Sequence Orthology more info
located_in mitotic spindle	IEA Inferred from Electronic Annotation more info
located_in mitotic spindle	ISO Inferred from Sequence Orthology more info

General protein information

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Preferred Names: pyrroline-5-carboxylate reductase 3

Names: P5C reductase 3; P5CR 3; pyrroline-5-carboxylate reductase-like protein

NP_079688.2

EC 1.5.1.2

XP_006521315.1

EC 1.5.1.2

NCBI Reference Sequences (RefSeq)

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RefSeqs maintained independently of Annotated Genomes

These reference sequences exist independently of genome builds. Explain

These reference sequences are curated independently of the genome annotation cycle, so their versions may not match the RefSeq versions in the current genome build. Identify version mismatches by comparing the version of the RefSeq in this section to the one reported in Genomic regions, transcripts, and products above.

mRNA and Protein(s)

NM_025412.3 → NP_079688.2 pyrroline-5-carboxylate reductase 3

See identical proteins and their annotated locations for NP_079688.2

Status: VALIDATED

Source sequence(s)

AC116520

Consensus CDS

CCDS37109.1

UniProtKB/Swiss-Prot

Q8R0P9, Q9D0X2, Q9DCC4

Related

ENSMUSP00000049605.8, ENSMUST00000053918.9

Conserved Domains (3) summary

PLN02688
Location:10 → 273

PLN02688; pyrroline-5-carboxylate reductase

pfam03807
Location:12 → 104

F420_oxidored; NADP oxidoreductase coenzyme F420-dependent

pfam14748
Location:166 → 270

P5CR_dimer; Pyrroline-5-carboxylate reductase dimerization

RefSeqs of Annotated Genomes: GCF_000001635.27-RS_2024_02

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCm39 C57BL/6J

Genomic

NC_000081.7 Reference GRCm39 C57BL/6J

Range

75788319..75793369 complement

Download

GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

XM_006521252.4 → XP_006521315.1 pyrroline-5-carboxylate reductase 3 isoform X1

Conserved Domains (1) summary

TIGR00112
Location:1 → 161

proC; pyrroline-5-carboxylate reductase