CYCD3;1 CYCLIN D3;1 [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: CYCD3;1
Official Full Name: CYCLIN D3;1
Primary source: TAIR:AT4G34160
Locus tag: AT4G34160
See related: Araport:AT4G34160
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: CYCD3; CYCLIN D3;1; F28A23.80; F28A23_80
Summary: encodes a cyclin D-type protein involved in the switch from cell proliferation to the final stages of differentiation. The gene is transcriptionally regulated by cytokinin and brassinosteroid. Protein interacts with cyclin-dependent kinase inhibitor ICK1.
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Genomic context

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See CYCD3;1 in Genome Data Viewer

Location:: chromosome: 4

Exon count:: 4

Sequence:: Chromosome: 4; NC_003075.7 (16357421..16359565)

Chromosome 4 - NC_003075.7 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003075.7

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

ANT does not regulate CYCD3;1 during petal growth.
Title: AINTEGUMENTA and the D-type cyclin CYCD3;1 independently contribute to petal size control in Arabidopsis: evidence for organ size compensation being an emergent rather than a determined property.
The direct target of both the bacterial cytokinins and plant putrescine was the expression of D3-type cyclins.
Title: Bacterial and plant signal integration via D3-type cyclins enhances symptom development in the Arabidopsis-Rhodococcus fascians interaction.
A combined action of ANT and CYCD3;1 promotes cell proliferation in leaf primordia and increases leaf size.
Title: Impact of segmental chromosomal duplications on leaf size in the grandifolia-D mutants of Arabidopsis thaliana.
Overlap between CYCD3;1 and E2Fa modulated genes substantiates their action in a common pathway with a key role in controlling the G1/S transition, with additional targets for CYCD3;1 in chromatin modification.
Title: Dissecting regulatory pathways of G1/S control in Arabidopsis: common and distinct targets of CYCD3;1, E2Fa and E2Fc.
CYCD3 activity is important for determining cell number in developing lateral organs and the relative contribution of the alternative processes of cell production and cell expansion to overall organ growth
Title: Arabidopsis CYCD3 D-type cyclins link cell proliferation and endocycles and are rate-limiting for cytokinin responses.
CYCD3;1 dominantly drives the G1/S transition, and in sucrose-depleted cells the decline in CYCD3;1 levels leads to G1 arrest, which is overcome by ectopic CYCD3;1 expression.
Title: The D-type cyclin CYCD3;1 is limiting for the G1-to-S-phase transition in Arabidopsis.
Effect of expression in tobacco on plant shoot apical meristem development.
Title: Ectopic expression of Arabidopsis CYCD2 and CYCD3 in tobacco has distinct effects on the structural organization of the shoot apical meristem.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_119579.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables protein binding	IPI Inferred from Physical Interaction more info	PubMed

Process	Evidence Code	Pubs
acts_upstream_of_or_within G1/S transition of mitotic cell cycle	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in guard mother cell differentiation	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within regulation of cell population proliferation	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to brassinosteroid	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cytokinin	IGI Inferred from Genetic Interaction more info	PubMed
acts_upstream_of_or_within response to cytokinin	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within response to sucrose	IEP Inferred from Expression Pattern more info	PubMed
acts_upstream_of_or_within seed development	IGI Inferred from Genetic Interaction more info	PubMed

Component	Evidence Code	Pubs
located_in nucleus	HDA more info	PubMed
located_in nucleus	ISM Inferred from Sequence Model more info

General protein information

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Preferred Names: CYCLIN D3;1

NP_195142.1

CYCLIN D3;1 (CYCD3;1); CONTAINS InterPro DOMAIN/s: Cyclin, C-terminal (InterPro:IPR004367), Cyclin D (InterPro:IPR015451), Cyclin-like (InterPro:IPR011028), Cyclin-related (InterPro:IPR013763), Cyclin, N-terminal (InterPro:IPR006671), Cyclin (InterPro:IPR006670); BEST Arabidopsis thaliana protein match is: CYCLIN D3;2 (TAIR:AT5G67260.1); Has 3155 Blast hits to 3153 proteins in 309 species: Archae - 0; Bacteria - 0; Metazoa - 1504; Fungi - 362; Plants - 1012; Viruses - 0; Other Eukaryotes - 277 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003075.7 Reference assembly

Range

16357421..16359565

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_119579.3 → NP_195142.1 CYCLIN D3;1 [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_195142.1

Status: REVIEWED

UniProtKB/Swiss-Prot

O49489, P42753, Q56XG2

UniProtKB/TrEMBL

A0A178UWK3, A0A5S9XYJ0

Conserved Domains (2) summary

cd20543
Location:86 → 184

CYCLIN_AtCycD-like_rpt1; first cyclin box found in plant cyclin-delta family

cd20544
Location:189 → 279

CYCLIN_AtCycD-like_rpt2; second cyclin box found in plant cyclin-delta family