MAG1 Calcineurin-like metallo-phosphoesterase superfamily protein [Arabidopsis thaliana (thale cress)] - Gene

Summary

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Official Symbol: MAG1
Official Full Name: Calcineurin-like metallo-phosphoesterase superfamily protein
Primary source: TAIR:AT3G47810
Locus tag: AT3G47810
See related: Araport:AT3G47810
Gene type: protein coding
RefSeq status: REVIEWED
Organism: Arabidopsis thaliana (ecotype: Columbia)
Lineage: Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
Also known as: ATVPS29; MAIGO 1; VACUOLAR PROTEIN SORTING 29; VPS29
Summary: Homolog of yeast retromer subunit VPS29. Part of a retromer-like protein complex involved in endosome to lysosome protein transport.
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Genomic context

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See MAG1 in Genome Data Viewer

Location:: chromosome: 3

Exon count:: 4

Sequence:: Chromosome: 3; NC_003074.8 (17637122..17639716, complement)

Chromosome 3 - NC_003074.8 Genomic Context describing neighboring genes

Genomic regions, transcripts, and products

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Go to reference sequence details

Genomic Sequence:: NC_003074.8

Go to nucleotide: Graphics FASTA GenBank

Bibliography

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GeneRIFs: Gene References Into Functions

What's a GeneRIF?

Arabidopsis retromer subunit AtVPS29 is involved in SLY1-mediated gibberellin signaling.
Title: Arabidopsis retromer subunit AtVPS29 is involved in SLY1-mediated gibberellin signaling.
VPS29 plays a crucial role in recycling VSRs from the PVC to the trans-Golgi network during the trafficking of soluble proteins to the lytic vacuole .
Title: Trafficking of vacuolar proteins: the crucial role of Arabidopsis vacuolar protein sorting 29 in recycling vacuolar sorting receptor.
A combination of immunoelectron and fluorescence microscopy show that VPS29p localize to the trans-Golgi network (TGN), which is considered to represent the early endosome of plants.
Title: Retromer recycles vacuolar sorting receptors from the trans-Golgi network.
VPS29 is required for endosome homeostasis, PIN protein cycling, and dynamic PIN1 repolarization during plant organ development.
Title: The retromer protein VPS29 links cell polarity and organ initiation in plants.
Findings suggest that MAG1/VPS29 protein is involved in recycling a plant receptor for the efficient sorting of seed storage proteins
Title: AtVPS29, a putative component of a retromer complex, is required for the efficient sorting of seed storage proteins.

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Interactions

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Products	Interactant	Other Gene	Complex	Source	Pubs	Description

General gene information

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Homology

Orthologs from OrthoDB

NM_114649.4

Supported by ESTs:

NM_202670.3

Supported by ESTs:

NM_202671.3

Supported by ESTs:

Gene Ontology Provided by TAIR

Function	Evidence Code	Pubs
enables molecular_function	ND No biological Data available more info

Process	Evidence Code	Pubs
acts_upstream_of_or_within endosome to lysosome transport	ISS Inferred from Sequence or Structural Similarity more info	PubMed
acts_upstream_of_or_within protein targeting to vacuole	IMP Inferred from Mutant Phenotype more info	PubMed
acts_upstream_of_or_within receptor recycling	IDA Inferred from Direct Assay more info	PubMed
involved_in regulation of auxin polar transport	IMP Inferred from Mutant Phenotype more info	PubMed
involved_in retrograde transport, endosome to Golgi	IEA Inferred from Electronic Annotation more info
acts_upstream_of_or_within vacuolar transport	IMP Inferred from Mutant Phenotype more info	PubMed

Component	Evidence Code	Pubs
located_in cytosol	HDA more info	PubMed
located_in intracellular membrane-bounded organelle	IDA Inferred from Direct Assay more info	PubMed
located_in membrane	IDA Inferred from Direct Assay more info	PubMed
located_in multivesicular body	IDA Inferred from Direct Assay more info	PubMed
part_of retromer complex	IDA Inferred from Direct Assay more info	PubMed
part_of retromer complex	ISS Inferred from Sequence or Structural Similarity more info	PubMed

General protein information

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Preferred Names: Calcineurin-like metallo-phosphoesterase superfamily protein

NP_190365.3

MAIGO 1 (MAG1); FUNCTIONS IN: hydrolase activity, acting on ester bonds, protein serine/threonine phosphatase activity; INVOLVED IN: endosome to lysosome transport, protein targeting to vacuole; LOCATED IN: microsome, retromer complex, membrane, multivesicular body; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phosphodiesterase MJ0936 (InterPro:IPR000979); Has 1298 Blast hits to 1264 proteins in 597 species: Archae - 104; Bacteria - 671; Metazoa - 203; Fungi - 159; Plants - 64; Viruses - 0; Other Eukaryotes - 97 (source: NCBI BLink).

NP_974399.2

MAIGO 1 (MAG1); FUNCTIONS IN: hydrolase activity, acting on ester bonds, protein serine/threonine phosphatase activity; INVOLVED IN: endosome to lysosome transport, protein targeting to vacuole; LOCATED IN: microsome, retromer complex, membrane, multivesicular body; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phosphodiesterase MJ0936 (InterPro:IPR000979); Has 1298 Blast hits to 1264 proteins in 597 species: Archae - 104; Bacteria - 671; Metazoa - 203; Fungi - 159; Plants - 64; Viruses - 0; Other Eukaryotes - 97 (source: NCBI BLink).

NP_974400.1

MAIGO 1 (MAG1); FUNCTIONS IN: hydrolase activity, acting on ester bonds, protein serine/threonine phosphatase activity; INVOLVED IN: endosome to lysosome transport, protein targeting to vacuole; LOCATED IN: microsome, retromer complex, membrane, multivesicular body; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Phosphodiesterase MJ0936 (InterPro:IPR000979); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

NCBI Reference Sequences (RefSeq)

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Genome Annotation

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference assembly

Genomic

NC_003074.8 Reference assembly

Range

17637122..17639716 complement

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GenBank, FASTA, Sequence Viewer (Graphics)

mRNA and Protein(s)

NM_202671.3 → NP_974400.1 Calcineurin-like metallo-phosphoesterase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974400.1

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3EAN1, Q9STT2

UniProtKB/TrEMBL

A0A178V791, A0A5S9XJ16

Conserved Domains (1) summary

cd07394
Location:3 → 180

MPP_Vps29; Homo sapiens Vps29 and related proteins, metallophosphatase domain
NM_114649.4 → NP_190365.3 Calcineurin-like metallo-phosphoesterase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_190365.3

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3EAN1, Q9STT2

UniProtKB/TrEMBL

A0A178V791, A0A5S9XJ16

Conserved Domains (1) summary

cd07394
Location:3 → 180

MPP_Vps29; Homo sapiens Vps29 and related proteins, metallophosphatase domain
NM_202670.3 → NP_974399.2 Calcineurin-like metallo-phosphoesterase superfamily protein [Arabidopsis thaliana]

See identical proteins and their annotated locations for NP_974399.2

Status: REVIEWED

UniProtKB/Swiss-Prot

Q3EAN1, Q9STT2

UniProtKB/TrEMBL

A0A178V791, A0A5S9XJ16

Conserved Domains (1) summary

cd07394
Location:3 → 180

MPP_Vps29; Homo sapiens Vps29 and related proteins, metallophosphatase domain