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    RING/U-box superfamily protein [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 824825, updated on 18-Sep-2024

    Summary

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    Official Full Name
    RING/U-box superfamily protein
    Primary source
    TAIR:AT3G56580
    Locus tag
    AT3G56580
    See related
    Araport:AT3G56580
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
    Also known as
    AtRZF1; RING Zinc Finger 1; RZF1; T5P19.5
    Summary
    Encodes a functional E3 ubiquitin ligase involved in the dehydration stress response and regulation of proline biosynthesis.
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    2
    Sequence:
    Chromosome: 3; NC_003074.8 (20961543..20963817)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene NAC domain containing protein 65 Neighboring gene SET domain-containing protein Neighboring gene hydroxyproline-rich glycoprotein family protein Neighboring gene phosphatidylinositol 4-kinase gamma-like protein

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The atrzf1 mutation of the novel RING-type E3 ubiquitin ligase increases proline contents and enhances drought tolerance in Arabidopsis. Ju HW, et al. Plant Sci, 2013 Apr. PMID 23415322
    2. Rhamnogalacturonan lyase 1 (RGL1), as a suppressor of E3 ubiquitin ligase Arabidopsis thaliana ring zinc finger 1 (AtRZF1), is involved in dehydration response to mediate proline synthesis and pectin rhamnogalacturonan-I composition. Min JH, et al. Plant J, 2024 Jul. PMID 38743860
    3. Arabidopsis thaliana Ubiquitin-Associated Protein 1 (AtUAP1) Interacts with redundant RING Zinc Finger 1 (AtRZF1) to Negatively Regulate Dehydration Response. Min JH, et al. Plant Cell Physiol, 2021 Oct 11. PMID 34086919
    4. Loss of Ribosomal Protein L24A (RPL24A) suppresses proline accumulation of Arabidopsis thaliana ring zinc finger 1 (atrzf1) mutant in response to osmotic stress. Park SH, et al. Biochem Biophys Res Commun, 2017 Dec 16. PMID 29066352
    5. PCA22 acts as a suppressor of atrzf1 to mediate proline accumulation in response to abiotic stress in Arabidopsis. Kim AR, et al. J Exp Bot, 2017 Mar 1. PMID 28369480, Free PMC Article

    See all (7) citations in PubMed

    GeneRIFs: Gene References Into Functions

    What's a GeneRIF?
    1. Rhamnogalacturonan lyase 1 (RGL1), as a suppressor of E3 ubiquitin ligase Arabidopsis thaliana ring zinc finger 1 (AtRZF1), is involved in dehydration response to mediate proline synthesis and pectin rhamnogalacturonan-I composition.
      Title: Rhamnogalacturonan lyase 1 (RGL1), as a suppressor of E3 ubiquitin ligase Arabidopsis thaliana ring zinc finger 1 (AtRZF1), is involved in dehydration response to mediate proline synthesis and pectin rhamnogalacturonan-I composition.
    2. Arabidopsis thaliana Ubiquitin-Associated Protein 1 (AtUAP1) Interacts with redundant RING Zinc Finger 1 (AtRZF1) to Negatively Regulate Dehydration Response.
      Title: Arabidopsis thaliana Ubiquitin-Associated Protein 1 (AtUAP1) Interacts with redundant RING Zinc Finger 1 (AtRZF1) to Negatively Regulate Dehydration Response.
    3. BES1/BZR1 Homolog 3 cooperates with E3 ligase AtRZF1 to regulate osmotic stress and brassinosteroid responses in Arabidopsis.
      Title: BES1/BZR1 Homolog 3 cooperates with E3 ligase AtRZF1 to regulate osmotic stress and brassinosteroid responses in Arabidopsis.
    4. Generally, pca22 mutant plants displayed suppressed atrzf1 insensitivity to dehydration and abscisic acid during early seedling growth. Additionally, the pca22 mutant exhibited shorter pollen tube length than wild-type (WT) and atrzf1 plants.
      Title: PCA22 acts as a suppressor of atrzf1 to mediate proline accumulation in response to abiotic stress in Arabidopsis.
    5. These results suggest that pca21 acts as partial suppressor of atrzf1 in the osmotic stress response through the Pro-mediated pathway.
      Title: Loss of Ribosomal Protein L24A (RPL24A) suppresses proline accumulation of Arabidopsis thaliana ring zinc finger 1 (atrzf1) mutant in response to osmotic stress.
    6. The E3 ligase AtRZF1 is an important regulator of water deficit stress during early seedling development.
      Title: The atrzf1 mutation of the novel RING-type E3 ubiquitin ligase increases proline contents and enhances drought tolerance in Arabidopsis.
    Submit: New GeneRIF Correction

    General gene information

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    Homology

    NM_001035797.1
    NM_115516.3
    NM_202719.1

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables ubiquitin protein ligase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    enables ubiquitin-protein transferase activity IDA
    Inferred from Direct Assay
    more info
    		 PubMed 
    Process Evidence Code Pubs
    acts_upstream_of_or_within negative regulation of proline biosynthetic process IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in regulation of response to osmotic stress IMP
    Inferred from Mutant Phenotype
    more info
    		 PubMed 
    involved_in response to osmotic stress IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    acts_upstream_of_or_within response to water deprivation IEP
    Inferred from Expression Pattern
    more info
    		 PubMed 
    Component Evidence Code Pubs
    located_in nucleus ISM
    Inferred from Sequence Model
    more info
    		  

    General protein information

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    Preferred Names
    RING/U-box superfamily protein
    NP_001030874.1
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 finger C1A (TAIR:AT2G40830.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).
    NP_567039.1
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 finger C1A (TAIR:AT2G40830.3); Has 10169 Blast hits to 10097 proteins in 280 species: Archae - 0; Bacteria - 6; Metazoa - 2759; Fungi - 920; Plants - 4864; Viruses - 13; Other Eukaryotes - 1607 (source: NCBI BLink).
    NP_974448.1
    • RING/U-box superfamily protein; FUNCTIONS IN: zinc ion binding; INVOLVED IN: biological_process unknown; LOCATED IN: cellular_component unknown; EXPRESSED IN: 18 plant structures; EXPRESSED DURING: 11 growth stages; CONTAINS InterPro DOMAIN/s: Zinc finger, RING-type (InterPro:IPR001841), Zinc finger, C3HC4 RING-type (InterPro:IPR018957); BEST Arabidopsis thaliana protein match is: RING-H2 finger C1A (TAIR:AT2G40830.3); Has 35333 Blast hits to 34131 proteins in 2444 species: Archae - 798; Bacteria - 22429; Metazoa - 974; Fungi - 991; Plants - 531; Viruses - 0; Other Eukaryotes - 9610 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      20961543..20963817
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_115516.3 → NP_567039.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_567039.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AK4, Q9LXY2
      UniProtKB/TrEMBL
      A0A178VB98, A0A5S9XLD8, A0A654FGX7
      Conserved Domains (2) summary
      cd16667
      Location:186 → 227
      RING-H2_RNF126_like; RING finger, H2 subclass, found in RING finger proteins RNF126, RNF115, and similar proteins
      pfam14369
      Location:6 → 37
      zinc_ribbon_9; zinc-ribbon

    2. NM_202719.1 → NP_974448.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_974448.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AK4, Q9LXY2
      UniProtKB/TrEMBL
      A0A178VB98, A0A5S9XLD8, A0A654FGX7
      Conserved Domains (2) summary
      cd16667
      Location:186 → 227
      RING-H2_RNF126_like; RING finger, H2 subclass, found in RING finger proteins RNF126, RNF115, and similar proteins
      pfam14369
      Location:6 → 37
      zinc_ribbon_9; zinc-ribbon

    3. NM_001035797.1 → NP_001030874.1  RING/U-box superfamily protein [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001030874.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q94AK4, Q9LXY2
      UniProtKB/TrEMBL
      A0A178VB98, A0A5S9XLD8, A0A654FGX7
      Conserved Domains (2) summary
      cd16667
      Location:186 → 227
      RING-H2_RNF126_like; RING finger, H2 subclass, found in RING finger proteins RNF126, RNF115, and similar proteins
      pfam14369
      Location:6 → 37
      zinc_ribbon_9; zinc-ribbon
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q94AK4.1

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