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    ketol-acid reductoisomerase [ Arabidopsis thaliana (thale cress) ]

    Gene ID: 825030, updated on 18-Sep-2024

    Summary

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    Official Full Name
    ketol-acid reductoisomerase
    Primary source
    TAIR:AT3G58610
    Locus tag
    AT3G58610
    See related
    Araport:AT3G58610
    Gene type
    protein coding
    RefSeq status
    REVIEWED
    Organism
    Arabidopsis thaliana (ecotype: Columbia)
    Lineage
    Eukaryota; Viridiplantae; Streptophyta; Embryophyta; Tracheophyta; Spermatophyta; Magnoliopsida; eudicotyledons; Gunneridae; Pentapetalae; rosids; malvids; Brassicales; Brassicaceae; Camelineae; Arabidopsis
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    Genomic context

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    Location:
    chromosome: 3
    Exon count:
    11
    Sequence:
    Chromosome: 3; NC_003074.8 (21671433..21675090)

    Chromosome 3 - NC_003074.8Genomic Context describing neighboring genes Neighboring gene PPR containing protein Neighboring gene Pentatricopeptide repeat (PPR) superfamily protein Neighboring gene Adaptin ear-binding coat-associated protein 1 NECAP-1 Neighboring gene tetratricopetide-repeat thioredoxin-like 4 Neighboring gene sequence-specific DNA binding transcription factor

    Genomic regions, transcripts, and products

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    Genomic Sequence:
    NC_003074.8

    Go to nucleotide: Graphics FASTA GenBank

    Bibliography

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    Related articles in PubMed

    1. The 14-3-3 isoforms chi and epsilon differentially bind client proteins from developing Arabidopsis seed. Swatek KN, et al. J Proteome Res, 2011 Sep 2. PMID 21766784
    2. Divalent metal ions in plant mitochondria and their role in interactions with proteins and oxidative stress-induced damage to respiratory function. Tan YF, et al. Plant Physiol, 2010 Feb. PMID 20018591, Free PMC Article
    3. Hydroponic isotope labelling of entire plants (HILEP) for quantitative plant proteomics; an oxidative stress case study. Bindschedler LV, et al. Phytochemistry, 2008 Jul. PMID 18538804
    4. The oligomeric stromal proteome of Arabidopsis thaliana chloroplasts. Peltier JB, et al. Mol Cell Proteomics, 2006 Jan. PMID 16207701
    5. Isolation and identification of ubiquitin-related proteins from Arabidopsis seedlings. Igawa T, et al. J Exp Bot, 2009. PMID 19429840, Free PMC Article

    See all (17) citations in PubMed

    GeneRIFs: Gene References Into Functions

    Pathways from PubChem

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    Interactions

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    Products Interactant Other Gene Complex Source Pubs Description

    General gene information

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    Homology

    NM_001084840.1
    NM_001203198.1
    NM_115723.4

    Gene Ontology Provided by TAIR

    Function Evidence Code Pubs
    enables copper ion binding HDA PubMed 
    enables ketol-acid reductoisomerase activity IEA
    Inferred from Electronic Annotation
    more info
    		  
    Process Evidence Code Pubs
    involved_in L-valine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    involved_in isoleucine biosynthetic process IEA
    Inferred from Electronic Annotation
    more info
    		  
    Component Evidence Code Pubs
    located_in apoplast HDA PubMed 
    located_in chloroplast HDA PubMed 
    located_in chloroplast ISM
    Inferred from Sequence Model
    more info
    		  
    located_in chloroplast envelope HDA PubMed 
    located_in chloroplast stroma HDA PubMed 
    located_in cytosol HDA PubMed 
    NOT located_in cytosol RCA
    inferred from Reviewed Computational Analysis
    more info
    		 PubMed 
    located_in mitochondrion HDA PubMed 
    located_in plant-type cell wall HDA PubMed 
    located_in plastid HDA PubMed 

    General protein information

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    Preferred Names
    ketol-acid reductoisomerase
    NP_001078309.1
    • ketol-acid reductoisomerase; FUNCTIONS IN: copper ion binding, ketol-acid reductoisomerase activity; INVOLVED IN: branched chain family amino acid biosynthetic process; LOCATED IN: mitochondrion, apoplast, chloroplast; EXPRESSED IN: 25 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acetohydroxy acid isomeroreductase, catalytic (InterPro:IPR013116), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), Acetohydroxy acid isomeroreductase C-terminal (InterPro:IPR000506), Ketol-acid reductoisomerase (InterPro:IPR016206), Acetohydroxy acid isomeroreductase (InterPro:IPR013023), NAD(P)-binding domain (InterPro:IPR016040); Has 7931 Blast hits to 7576 proteins in 2285 species: Archae - 226; Bacteria - 4872; Metazoa - 2; Fungi - 269; Plants - 111; Viruses - 0; Other Eukaryotes - 2451 (source: NCBI BLink).
    NP_001190127.1
    • ketol-acid reductoisomerase; CONTAINS InterPro DOMAIN/s: Acetohydroxy acid isomeroreductase, catalytic (InterPro:IPR013116), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), Acetohydroxy acid isomeroreductase C-terminal (InterPro:IPR000506), Ketol-acid reductoisomerase (InterPro:IPR016206), Acetohydroxy acid isomeroreductase (InterPro:IPR013023), NAD(P)-binding domain (InterPro:IPR016040).
    NP_191420.1
    • ketol-acid reductoisomerase; FUNCTIONS IN: copper ion binding, ketol-acid reductoisomerase activity; INVOLVED IN: response to cadmium ion, branched chain family amino acid biosynthetic process; LOCATED IN: in 6 components; EXPRESSED IN: 26 plant structures; EXPRESSED DURING: 15 growth stages; CONTAINS InterPro DOMAIN/s: Acetohydroxy acid isomeroreductase, catalytic (InterPro:IPR013116), 6-phosphogluconate dehydrogenase, C-terminal-like (InterPro:IPR008927), Dehydrogenase, multihelical (InterPro:IPR013328), Acetohydroxy acid isomeroreductase C-terminal (InterPro:IPR000506), Ketol-acid reductoisomerase (InterPro:IPR016206), Acetohydroxy acid isomeroreductase (InterPro:IPR013023), NAD(P)-binding domain (InterPro:IPR016040); Has 7931 Blast hits to 7576 proteins in 2285 species: Archae - 226; Bacteria - 4872; Metazoa - 2; Fungi - 269; Plants - 111; Viruses - 0; Other Eukaryotes - 2451 (source: NCBI BLink).

    NCBI Reference Sequences (RefSeq)

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    Genome Annotation

    The following sections contain reference sequences that belong to a specific genome build. Explain

    Reference assembly

    Genomic

    1. NC_003074.8 Reference assembly

      Range
      21671433..21675090
      Download
      GenBank, FASTA, Sequence Viewer (Graphics)

    mRNA and Protein(s)

    1. NM_001203198.1 → NP_001190127.1  ketol-acid reductoisomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001190127.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05758, Q42559
      UniProtKB/TrEMBL
      A0A178VHJ5, A0A5S9XM31, B9DH71
      Conserved Domains (1) summary
      COG0059
      Location:114 → 447
      IlvC; Ketol-acid reductoisomerase [Amino acid transport and metabolism, Coenzyme transport and metabolism]

    2. NM_115723.4 → NP_191420.1  ketol-acid reductoisomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_191420.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05758, Q42559
      UniProtKB/TrEMBL
      A0A178VHJ5, A0A5S9XM31, B9DH71
      Conserved Domains (1) summary
      COG0059
      Location:114 → 447
      IlvC; Ketol-acid reductoisomerase [Amino acid transport and metabolism, Coenzyme transport and metabolism]

    3. NM_001084840.1 → NP_001078309.1  ketol-acid reductoisomerase [Arabidopsis thaliana]

      See identical proteins and their annotated locations for NP_001078309.1

      Status: REVIEWED

      UniProtKB/Swiss-Prot
      Q05758, Q42559
      UniProtKB/TrEMBL
      A0A178VHJ5, A0A5S9XM31, B9DH71
      Conserved Domains (1) summary
      COG0059
      Location:114 → 447
      IlvC; Ketol-acid reductoisomerase [Amino acid transport and metabolism, Coenzyme transport and metabolism]
    Nucleotide Protein
    Heading Accession and Version
    Protein Accession Links
    GenPept Link UniProtKB Link
    Q05758.2

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